ES2064470T3 - Liposomas en los cuales se inhibe la adsorcion de proteinas. - Google Patents

Liposomas en los cuales se inhibe la adsorcion de proteinas.

Info

Publication number
ES2064470T3
ES2064470T3 ES89402290T ES89402290T ES2064470T3 ES 2064470 T3 ES2064470 T3 ES 2064470T3 ES 89402290 T ES89402290 T ES 89402290T ES 89402290 T ES89402290 T ES 89402290T ES 2064470 T3 ES2064470 T3 ES 2064470T3
Authority
ES
Spain
Prior art keywords
liposomes
liposoma
adsorption
proteins
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89402290T
Other languages
English (en)
Inventor
Hiroshi Yoshida
Hiroshi Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Application granted granted Critical
Publication of ES2064470T3 publication Critical patent/ES2064470T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN AGENTES PARA INHIBIR LA ADSORCION DE PROTEINAS EN LA SIPERFICIE DE LIPOSOMAS Y LIPOSOMAS QUE ESTAN LIBRES DE AGLUTINACION, POR UNION DE DICHO AGENTE DE INHIBICION A LA SUPERFICIE. LOS AGENTES DE INHIBICION ANTES MENCIONADOS CONTIENEN UNA PARTE HIDROFOBA Y UNA PARTE DE CADENA MACROMOLECULAR HIDROFILA. LA ADSORCION DE PROTEINAS DE PLASMA SOBRE LOS LIPOSOMAS SE INHIBE DEBIDO A LA PARTE HIDROFILA EXPUESTA EN LA SUPERFICIE DEL LIPOSOMA, CON EL RESULTADO DE QUE SE IMPIDE LA AGLUTINACION DE LOS LIPOSOMAS EN EL PLASMA. POR TANTO, NO HAY PELIGRO DE EMBOLISMO EN LOS VASOS SANGUINEOS QUE INHIBEN EL FLUJO SANGUINEO CUANDO LOS LIPOSOMAS SE INTRODUCEN EN EL CUERPO VIVO. CONSIGUIENTEMENTE, LOS LIPOSOMAS SON ESPECIALMENTE MUY UTILES COMO ERITROCITOS ARTIFICIALES, POR LO QUE ES NECESARIO UNA GRAN DOSIS DE LIPOSOMAS PARA ADMINISTRACION. ADEMAS, CUANDO LOS LIPOSOMAS SE INTRODUCEN EN EL CUERPO VIVO, LA PROTEINA ANTICUERPO (INMUNOGLOBULINA) AL LIPOSOMA, QUE ES UN ANTIGENO, ES ADSORBIDA EN EL LIPOSOMA PARA PRODUCIR EL RECONOCIMIENTO DE CUERPOS EXTRAÑOS EN LOS FAGOCITOS (MACROFAGO), CON EL RESULTADO DE QUE LOS LIPOSOMAS SE INCLUYEN EN EL MACROFAGO Y DESAPARECEN EN UN CORTO PERIODO DE TIEMPO. ASI, LA INHIBICION DE LA ADSORCION DE PROTEINA EN LIPOSOMA PUEDE RETRASAR LA DESAPARICION DEL LIPOSOMA EN EL PLASMA. ADEMAS, SE DESCRIBE UN METODO PARA PREPARAR LOS LIPOSOMAS ANTES DESCRITOS.
ES89402290T 1988-08-11 1989-08-11 Liposomas en los cuales se inhibe la adsorcion de proteinas. Expired - Lifetime ES2064470T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19891588 1988-08-11
JP1063507A JPH0720857B2 (ja) 1988-08-11 1989-03-17 リポソームおよびその製法

Publications (1)

Publication Number Publication Date
ES2064470T3 true ES2064470T3 (es) 1995-02-01

Family

ID=26404636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89402290T Expired - Lifetime ES2064470T3 (es) 1988-08-11 1989-08-11 Liposomas en los cuales se inhibe la adsorcion de proteinas.

Country Status (5)

Country Link
US (3) US5676971A (es)
EP (1) EP0354855B1 (es)
JP (1) JPH0720857B2 (es)
DE (1) DE68919772T2 (es)
ES (1) ES2064470T3 (es)

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Also Published As

Publication number Publication date
JPH0720857B2 (ja) 1995-03-08
US5846458A (en) 1998-12-08
EP0354855A3 (en) 1991-06-05
DE68919772T2 (de) 1995-07-13
US5676971A (en) 1997-10-14
JPH02149512A (ja) 1990-06-08
US5593622A (en) 1997-01-14
EP0354855A2 (en) 1990-02-14
EP0354855B1 (en) 1994-12-07
DE68919772D1 (de) 1995-01-19

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