ES2064729T3 - Complejos de rutenio (iii) como agentes antineoplasticos. - Google Patents
Complejos de rutenio (iii) como agentes antineoplasticos.Info
- Publication number
- ES2064729T3 ES2064729T3 ES90906961T ES90906961T ES2064729T3 ES 2064729 T3 ES2064729 T3 ES 2064729T3 ES 90906961 T ES90906961 T ES 90906961T ES 90906961 T ES90906961 T ES 90906961T ES 2064729 T3 ES2064729 T3 ES 2064729T3
- Authority
- ES
- Spain
- Prior art keywords
- complexes
- antineoplastic agents
- ruthenium
- iii
- sub
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LOS COMPLEJOS QUE TIENEN LA FORMULA (I), EN DONDE: R SUB 1 Y R SUB 2 SON GRUPOS DE ALQUILO, ALQUILARILO, ARILO O TETARILO, A ES CLORO, O UN GRUPO QUE TIENE LA FORMULA (A), (R1 Y R2 SON COMO SE HA DEFINIDO ARRIBA); B ES UN LIGANDO DE NITROGENO SELECCIONADO DEL AMONIACO, AMINAS PRIMARIAS, SECUNDARIAS O TERCIARIAS O NITROGENO QUE CONTIENE HETEROCICLOS, SON UTILES COMO AGENTES ANTINEOPLASTICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8920385A IT1230145B (it) | 1989-05-05 | 1989-05-05 | Complessi di rutenio (iii) come agenti antineoplastici. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2064729T3 true ES2064729T3 (es) | 1995-02-01 |
Family
ID=11166245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90906961T Expired - Lifetime ES2064729T3 (es) | 1989-05-05 | 1990-05-02 | Complejos de rutenio (iii) como agentes antineoplasticos. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5409893A (es) |
| EP (1) | EP0471709B1 (es) |
| AT (1) | ATE114663T1 (es) |
| AU (1) | AU629341B2 (es) |
| DE (1) | DE69014619T2 (es) |
| ES (1) | ES2064729T3 (es) |
| IT (1) | IT1230145B (es) |
| WO (1) | WO1990013553A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9317686D0 (en) * | 1993-08-25 | 1993-10-13 | Johnson Matthey Plc | Pharmaceutical compositions |
| IT1284101B1 (it) * | 1996-07-02 | 1998-05-08 | Sigea Srl | Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| GB0028025D0 (en) * | 2000-11-17 | 2001-01-03 | Univ York | Compounds |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| EP2671507A3 (en) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-informatics system |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| EP2152084B1 (en) * | 2007-06-11 | 2013-12-18 | Niiki Pharma Inc. | Method of manufacturing a ruthenium complex |
| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| EP2509599B1 (en) * | 2009-12-11 | 2014-08-13 | Niiki Pharma Inc. | Method for treating pancreatic cancer |
| CN103153303A (zh) * | 2010-07-18 | 2013-06-12 | 尼基制药公司 | 使用钌络合物的联合疗法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN103665046A (zh) * | 2012-08-31 | 2014-03-26 | 澳门科技大学 | 钌配合物及其制备方法和应用 |
| CN104744518B (zh) * | 2015-02-11 | 2018-08-07 | 中国中医科学院中药研究所 | 金属钌配合物及其制备方法和应用 |
| CN115028665B (zh) * | 2022-06-06 | 2023-12-26 | 山西大学 | 一种以手性甲硫氨酸和5-氯-8-羟基喹啉为配体的亚硝酰钌配合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557143A (en) * | 1967-08-30 | 1971-01-19 | Colgate Palmolive Co | Bridged bicyclic ferrocene ethers and thioethers |
| US3576012A (en) * | 1967-11-02 | 1971-04-20 | Hercules Inc | Nickel salts of iminoheterocyclicamides |
-
1989
- 1989-05-05 IT IT8920385A patent/IT1230145B/it active
-
1990
- 1990-05-02 WO PCT/EP1990/000699 patent/WO1990013553A1/en not_active Ceased
- 1990-05-02 DE DE69014619T patent/DE69014619T2/de not_active Expired - Fee Related
- 1990-05-02 ES ES90906961T patent/ES2064729T3/es not_active Expired - Lifetime
- 1990-05-02 EP EP90906961A patent/EP0471709B1/en not_active Expired - Lifetime
- 1990-05-02 AU AU55302/90A patent/AU629341B2/en not_active Ceased
- 1990-05-02 AT AT90906961T patent/ATE114663T1/de not_active IP Right Cessation
- 1990-05-02 US US07/773,939 patent/US5409893A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5409893A (en) | 1995-04-25 |
| AU5530290A (en) | 1990-11-29 |
| IT1230145B (it) | 1991-10-14 |
| WO1990013553A1 (en) | 1990-11-15 |
| EP0471709B1 (en) | 1994-11-30 |
| DE69014619T2 (de) | 1995-05-18 |
| EP0471709A1 (en) | 1992-02-26 |
| ATE114663T1 (de) | 1994-12-15 |
| AU629341B2 (en) | 1992-10-01 |
| DE69014619D1 (de) | 1995-01-12 |
| IT8920385A0 (it) | 1989-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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