IT1230145B - Complessi di rutenio (iii) come agenti antineoplastici. - Google Patents

Complessi di rutenio (iii) come agenti antineoplastici.

Info

Publication number
IT1230145B
IT1230145B IT8920385A IT2038589A IT1230145B IT 1230145 B IT1230145 B IT 1230145B IT 8920385 A IT8920385 A IT 8920385A IT 2038589 A IT2038589 A IT 2038589A IT 1230145 B IT1230145 B IT 1230145B
Authority
IT
Italy
Prior art keywords
pct
complexes
ruthenium
iii
antineoplastic agents
Prior art date
Application number
IT8920385A
Other languages
English (en)
Other versions
IT8920385A0 (it
Inventor
Enzo Alessio
Giovanni Mestroni
Sabrina Pacor
Gianni Sava
Silvano Spinelli
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Priority to IT8920385A priority Critical patent/IT1230145B/it
Publication of IT8920385A0 publication Critical patent/IT8920385A0/it
Priority to US07/773,939 priority patent/US5409893A/en
Priority to DE69014619T priority patent/DE69014619T2/de
Priority to PCT/EP1990/000699 priority patent/WO1990013553A1/en
Priority to ES90906961T priority patent/ES2064729T3/es
Priority to AT90906961T priority patent/ATE114663T1/de
Priority to AU55302/90A priority patent/AU629341B2/en
Priority to EP90906961A priority patent/EP0471709B1/en
Application granted granted Critical
Publication of IT1230145B publication Critical patent/IT1230145B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8920385A 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici. IT1230145B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT8920385A IT1230145B (it) 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici.
US07/773,939 US5409893A (en) 1989-05-05 1990-05-02 Ruthenium(III) complexes as antineoplastic agents
DE69014619T DE69014619T2 (de) 1989-05-05 1990-05-02 Ruthenium(iii)-komplexe als antineoplastische mittel.
PCT/EP1990/000699 WO1990013553A1 (en) 1989-05-05 1990-05-02 Ruthenium(iii) complexes as antineoplastic agents
ES90906961T ES2064729T3 (es) 1989-05-05 1990-05-02 Complejos de rutenio (iii) como agentes antineoplasticos.
AT90906961T ATE114663T1 (de) 1989-05-05 1990-05-02 Ruthenium(iii)-komplexe als antineoplastische mittel.
AU55302/90A AU629341B2 (en) 1989-05-05 1990-05-02 Ruthenium(iii) complexes as antineoplastic agents
EP90906961A EP0471709B1 (en) 1989-05-05 1990-05-02 Ruthenium(iii) complexes as antineoplastic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920385A IT1230145B (it) 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici.

Publications (2)

Publication Number Publication Date
IT8920385A0 IT8920385A0 (it) 1989-05-05
IT1230145B true IT1230145B (it) 1991-10-14

Family

ID=11166245

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8920385A IT1230145B (it) 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici.

Country Status (8)

Country Link
US (1) US5409893A (it)
EP (1) EP0471709B1 (it)
AT (1) ATE114663T1 (it)
AU (1) AU629341B2 (it)
DE (1) DE69014619T2 (it)
ES (1) ES2064729T3 (it)
IT (1) IT1230145B (it)
WO (1) WO1990013553A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317686D0 (en) * 1993-08-25 1993-10-13 Johnson Matthey Plc Pharmaceutical compositions
IT1284101B1 (it) * 1996-07-02 1998-05-08 Sigea Srl Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
GB0028025D0 (en) * 2000-11-17 2001-01-03 Univ York Compounds
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2441262T3 (es) * 2007-06-11 2014-02-03 Niiki Pharma Inc. Método de fabricación de un complejo de rutenio
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
EP2509599B1 (en) * 2009-12-11 2014-08-13 Niiki Pharma Inc. Method for treating pancreatic cancer
WO2012012305A2 (en) * 2010-07-18 2012-01-26 Niiki Pharma Inc. Combination therapy using a ruthenium complex
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103665046A (zh) * 2012-08-31 2014-03-26 澳门科技大学 钌配合物及其制备方法和应用
CN104744518B (zh) * 2015-02-11 2018-08-07 中国中医科学院中药研究所 金属钌配合物及其制备方法和应用
CN115028665B (zh) * 2022-06-06 2023-12-26 山西大学 一种以手性甲硫氨酸和5-氯-8-羟基喹啉为配体的亚硝酰钌配合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557143A (en) * 1967-08-30 1971-01-19 Colgate Palmolive Co Bridged bicyclic ferrocene ethers and thioethers
US3576012A (en) * 1967-11-02 1971-04-20 Hercules Inc Nickel salts of iminoheterocyclicamides

Also Published As

Publication number Publication date
ATE114663T1 (de) 1994-12-15
IT8920385A0 (it) 1989-05-05
EP0471709A1 (en) 1992-02-26
ES2064729T3 (es) 1995-02-01
EP0471709B1 (en) 1994-11-30
DE69014619T2 (de) 1995-05-18
AU5530290A (en) 1990-11-29
US5409893A (en) 1995-04-25
WO1990013553A1 (en) 1990-11-15
DE69014619D1 (de) 1995-01-12
AU629341B2 (en) 1992-10-01

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