IT1230145B - Complessi di rutenio (iii) come agenti antineoplastici. - Google Patents

Complessi di rutenio (iii) come agenti antineoplastici.

Info

Publication number: IT1230145B
Authority: IT; Italy
Prior art keywords: pct; complexes; ruthenium; iii; antineoplastic agents
Prior art date: 1989-05-05

Application number

IT8920385A

Other languages

English (en)

Other versions

IT8920385A0 (it

Inventor

Enzo Alessio

Giovanni Mestroni

Sabrina Pacor

Gianni Sava

Silvano Spinelli

Original Assignee

Boehringer Biochemia Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-05

Filing date

1989-05-05

Publication date

1991-10-14

1989-05-05 Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl

1989-05-05 Priority to IT8920385A priority Critical patent/IT1230145B/it

1989-05-05 Publication of IT8920385A0 publication Critical patent/IT8920385A0/it

1990-05-02 Priority to EP90906961A priority patent/EP0471709B1/en

1990-05-02 Priority to AU55302/90A priority patent/AU629341B2/en

1990-05-02 Priority to PCT/EP1990/000699 priority patent/WO1990013553A1/en

1990-05-02 Priority to DE69014619T priority patent/DE69014619T2/de

1990-05-02 Priority to AT90906961T priority patent/ATE114663T1/de

1990-05-02 Priority to US07/773,939 priority patent/US5409893A/en

1990-05-02 Priority to ES90906961T priority patent/ES2064729T3/es

1991-10-14 Application granted granted Critical

1991-10-14 Publication of IT1230145B publication Critical patent/IT1230145B/it

Links

229940034982 antineoplastic agent Drugs 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
BPEVHDGLPIIAGH-UHFFFAOYSA-N ruthenium(3+) Chemical class [Ru+3] BPEVHDGLPIIAGH-UHFFFAOYSA-N 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003057 platinum Chemical class 0.000 abstract 1
150000003462 sulfoxides Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT8920385A 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici. IT1230145B (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IT8920385A IT1230145B (it)	1989-05-05	1989-05-05	Complessi di rutenio (iii) come agenti antineoplastici.
EP90906961A EP0471709B1 (en)	1989-05-05	1990-05-02	Ruthenium(iii) complexes as antineoplastic agents
AU55302/90A AU629341B2 (en)	1989-05-05	1990-05-02	Ruthenium(iii) complexes as antineoplastic agents
PCT/EP1990/000699 WO1990013553A1 (en)	1989-05-05	1990-05-02	Ruthenium(iii) complexes as antineoplastic agents
DE69014619T DE69014619T2 (de)	1989-05-05	1990-05-02	Ruthenium(iii)-komplexe als antineoplastische mittel.
AT90906961T ATE114663T1 (de)	1989-05-05	1990-05-02	Ruthenium(iii)-komplexe als antineoplastische mittel.
US07/773,939 US5409893A (en)	1989-05-05	1990-05-02	Ruthenium(III) complexes as antineoplastic agents
ES90906961T ES2064729T3 (es)	1989-05-05	1990-05-02	Complejos de rutenio (iii) como agentes antineoplasticos.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8920385A IT1230145B (it)	1989-05-05	1989-05-05	Complessi di rutenio (iii) come agenti antineoplastici.

Publications (2)

Publication Number	Publication Date
IT8920385A0 IT8920385A0 (it)	1989-05-05
IT1230145B true IT1230145B (it)	1991-10-14

Family

ID=11166245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8920385A IT1230145B (it)	1989-05-05	1989-05-05	Complessi di rutenio (iii) come agenti antineoplastici.

Country Status (8)

Country	Link
US (1)	US5409893A (it)
EP (1)	EP0471709B1 (it)
AT (1)	ATE114663T1 (it)
AU (1)	AU629341B2 (it)
DE (1)	DE69014619T2 (it)
ES (1)	ES2064729T3 (it)
IT (1)	IT1230145B (it)
WO (1)	WO1990013553A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9317686D0 (en) *	1993-08-25	1993-10-13	Johnson Matthey Plc	Pharmaceutical compositions
IT1284101B1 (it) *	1996-07-02	1998-05-08	Sigea Srl	Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici
CA2385528C (en)	1999-10-01	2013-12-10	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GB0028025D0 (en) *	2000-11-17	2001-01-03	Univ York	Compounds
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
CN101677572B (zh) *	2007-06-11	2013-11-20	尼基制药公司	制备钌络合物的方法
EP2398500B1 (en)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Glutathione-based drug delivery system
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
PT2509599E (pt) *	2009-12-11	2014-10-15	Niiki Pharma Inc	Processo para o tratamento de cancro pancreático
JP6034288B2 (ja) *	2010-07-18	2016-11-30	ニーキファーマインコーポレイテッド	ルテニウム錯体を用いる併用療法
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN103665046A (zh) *	2012-08-31	2014-03-26	澳门科技大学	钌配合物及其制备方法和应用
CN104744518B (zh) *	2015-02-11	2018-08-07	中国中医科学院中药研究所	金属钌配合物及其制备方法和应用
CN115028665B (zh) *	2022-06-06	2023-12-26	山西大学	一种以手性甲硫氨酸和5-氯-8-羟基喹啉为配体的亚硝酰钌配合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3557143A (en) *	1967-08-30	1971-01-19	Colgate Palmolive Co	Bridged bicyclic ferrocene ethers and thioethers
US3576012A (en) *	1967-11-02	1971-04-20	Hercules Inc	Nickel salts of iminoheterocyclicamides

1989
- 1989-05-05 IT IT8920385A patent/IT1230145B/it active
1990
- 1990-05-02 WO PCT/EP1990/000699 patent/WO1990013553A1/en not_active Ceased
- 1990-05-02 AT AT90906961T patent/ATE114663T1/de not_active IP Right Cessation
- 1990-05-02 EP EP90906961A patent/EP0471709B1/en not_active Expired - Lifetime
- 1990-05-02 ES ES90906961T patent/ES2064729T3/es not_active Expired - Lifetime
- 1990-05-02 DE DE69014619T patent/DE69014619T2/de not_active Expired - Fee Related
- 1990-05-02 US US07/773,939 patent/US5409893A/en not_active Expired - Lifetime
- 1990-05-02 AU AU55302/90A patent/AU629341B2/en not_active Ceased

Also Published As

Publication number	Publication date
AU629341B2 (en)	1992-10-01
DE69014619T2 (de)	1995-05-18
WO1990013553A1 (en)	1990-11-15
ATE114663T1 (de)	1994-12-15
US5409893A (en)	1995-04-25
IT8920385A0 (it)	1989-05-05
EP0471709A1 (en)	1992-02-26
AU5530290A (en)	1990-11-29
ES2064729T3 (es)	1995-02-01
EP0471709B1 (en)	1994-11-30
DE69014619D1 (de)	1995-01-12

Similar Documents

Publication	Publication Date	Title
ATE114663T1 (de)	1994-12-15	Ruthenium(iii)-komplexe als antineoplastische mittel.
ATE225341T1 (de)	2002-10-15	In 6-position durch thio substituierte paclitaxele
IT8820074A0 (it)	1988-04-01	Complessi di platino (ii), loro preparazione e impiego come antitumorali.
GB8922026D0 (en)	1989-11-15	Novel anti-viral and cytotoxic agent
NO960754D0 (no)	1996-02-23	Farmasöytiske blandinger omfattende metall-komplekser
GR3017282T3 (en)	1995-11-30	Novel arylpyridazines, their manufacture, use and medicaments containing them.
BR9406779A (pt)	1996-02-06	Complexos de inclusão de multicomponentes altamente solúveis contendo uma droga de tipo básico um ácido e uma ciclodextrina
DE69407594D1 (de)	1998-02-05	Spielzeugbausatz und bauelemente dafür
ID28003A (id)	2001-05-03	Turunan-turunan adamantana
NO305078B1 (no)	1999-03-29	Heteroatomholdige ligander og metallkomplekser av disse, anvendelse av kompleksene og sett for fremstilling av dem
ATE210988T1 (de)	2002-01-15	Zytotoxischer aminozucker und verwandte zuckerderivate von indolopyrrolocarbazolen
CA2114136A1 (en)	1993-02-04	Gallium (iii) complexes, process for their obtention and pharmaceutical compositions containing them
AU4484989A (en)	1990-06-12	Water soluble 1,2-diaminocyclohexane platinum (iv) complexes as antitumor agents
IL118670A (en)	2000-07-26	Enantiomerically pure bisphosphines their preparation metal complexes and their use
DE3579730D1 (de)	1990-10-25	Eisen-3-hydroxypyron- oder 3-hydroxypyridon-komplexe und diese enthaltende pharmazeutische zusammensetzungen.
PH24452A (en)	1990-06-25	(2,2-bis(aminomethyl 1,3,propanediol-n,n)platinum complexes
DK0701440T3 (da)	2000-06-13	Tri(platin)komplekser
ITMI940610A0 (it)	1994-03-31	Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
EP0646589A3 (en)	1995-06-28	Anti-tumor platinum (IV) complexes.
FR2675996B1 (fr)	1993-10-15	Compositions sanogenes dietetiques complexes.
DE69107533D1 (de)	1995-03-30	2,2'-Bis(dicyclopentylphosphino)-1,1'-binaphthyl und Metallkomplexe davon.
IT1237509B (it)	1993-06-08	Complessi con le ciclodestrine indicati per il trattamento di tutte leforme anemiche da carenza di folati, loro preparazione e relative composizioni farmaceutiche
DE60133491D1 (de)	2008-05-15	Zusammensetzung mit demethylcantharidin in kombination mit platinhaltigen antikrebsmitteln und ihre verwendung
NO894594D0 (no)	1989-11-17	Farmasoeytiske sammensetninger omfattende labdan diterpenoid-derivater og pyrimido(6,1-a)isoquinolin-4-ono-derivater.
NO900564L (no)	1990-08-09	Overflateaktivt middel.

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970530