ES2065686T3 - Metodos para separar ligandos de una superficie de particula. - Google Patents

Metodos para separar ligandos de una superficie de particula.

Info

Publication number
ES2065686T3
ES2065686T3 ES91909347T ES91909347T ES2065686T3 ES 2065686 T3 ES2065686 T3 ES 2065686T3 ES 91909347 T ES91909347 T ES 91909347T ES 91909347 T ES91909347 T ES 91909347T ES 2065686 T3 ES2065686 T3 ES 2065686T3
Authority
ES
Spain
Prior art keywords
particle surface
ligand
leagues
separate
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909347T
Other languages
English (en)
Inventor
Ronald J Berenson
Dale R Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CellPro Inc
Original Assignee
CellPro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24041719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2065686(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CellPro Inc filed Critical CellPro Inc
Application granted granted Critical
Publication of ES2065686T3 publication Critical patent/ES2065686T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/828—Protein A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Abstract

SE PROPORCIONA UN METODO PARA EXTRAER UN SEGUNDO LIGANTE A PARTIR DE LA SUPERFICIE DE UNA PARTICULA, SIN AFECTAR SUBSTANCIALMENTE LA SUPERFICIE DE LA PARTICULA, QUE COMPRENDE EL PASO DE EXPOSICION DE LA PARTICULA A UN PRIMER LIGANTE INMOVILIZADO EN UN SOPORTE, EN DONDE SE EXPONE LA PARTICULA EN LAS CONDICIONES ADECUADAS Y DURANTE UN TIEMPO DE PASO SUFICIENTE PARA PERMITIR QUE EL SEGUNDO LIGANTE SE DESORBA DE LA SUPERFICIE DE LA PARTICULA Y EN DONDE EL PRIMER LIGANTE TIENE UNA AFINIDAD CON EL SEGUNDO LIGANTE QUE ES, AL MENOS, DOS ORDENES DE MAGNITUD SUPERIOR A LA AFINIDAD DEL SEGUNDO LIGANTE PARA LA SUPERFICIE DE LA PARTICULA, DE TAL FORMA QUE EL SEGUNDO LIGANTE SE EXTRAE DE LA SUPERFICIE DE LA PARTICULA SIN AFECTAR SUBSTANCIALMENTE LA SUPERFICIE DE LA PARTICULA.
ES91909347T 1990-04-23 1991-04-23 Metodos para separar ligandos de una superficie de particula. Expired - Lifetime ES2065686T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/513,056 US5378624A (en) 1990-04-23 1990-04-23 Methods for removing ligands from a particle surface

Publications (1)

Publication Number Publication Date
ES2065686T3 true ES2065686T3 (es) 1995-02-16

Family

ID=24041719

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909347T Expired - Lifetime ES2065686T3 (es) 1990-04-23 1991-04-23 Metodos para separar ligandos de una superficie de particula.

Country Status (9)

Country Link
US (1) US5378624A (es)
EP (1) EP0526577B1 (es)
JP (1) JP2721040B2 (es)
AT (1) ATE114484T1 (es)
CA (1) CA2081202C (es)
DE (1) DE69105497T2 (es)
DK (1) DK0526577T3 (es)
ES (1) ES2065686T3 (es)
WO (1) WO1991016088A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536475A (en) * 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US5635387A (en) * 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
WO1992007243A1 (en) * 1990-10-18 1992-04-30 Cellpro, Incorporated An apparatus and method for separating particles using a pliable vessel
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US6120735A (en) * 1992-02-26 2000-09-19 The Ohio States University Fractional cell sorter
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) * 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
BR9813233A (pt) 1997-09-29 2000-08-22 Point Therapeutics Inc Estimulação de células hematopoéticas in vitro
JP2002513762A (ja) * 1998-05-04 2002-05-14 ポイント セラピューティクス， インコーポレイテッド 造血刺激
BR9910907A (pt) 1998-06-05 2002-02-13 Point Therapeutics Inc Compostos cìclicos de boroprolina
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
KR102300886B1 (ko) * 2013-12-02 2021-09-10 삼성전자주식회사 표면 리간드 화합물 제거 방법
US9492840B2 (en) * 2013-12-02 2016-11-15 Samsung Electronics Co., Ltd. Methods of removing surface ligand compounds
US11608489B2 (en) * 2016-04-30 2023-03-21 BioLegend, Inc. Compositions and methods for performing magnetibuoyant separations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276206A (en) * 1979-01-18 1981-06-30 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
JPS603367B2 (ja) * 1979-10-09 1985-01-28 旭化成株式会社 白血球分離法および白血球分離材
US4513088A (en) * 1983-03-30 1985-04-23 The Board Of Trustees Of The Leland Stanford Junior University Assay for monoclonal antibody against surface Ig of a human B cell tumor
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
US4714680B1 (en) * 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US4965204A (en) * 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4935339A (en) * 1985-05-07 1990-06-19 Nichols Institute Diagnostics Delayed solid phase immunologic assay
US5262334A (en) * 1986-01-30 1993-11-16 Fred Hutchinson Cancer Research Center Method for immunoselection of cells using avidin and biotin
US5215927A (en) * 1986-01-30 1993-06-01 Fred Hutchinson Cancer Research Center Method for immunoselection of cells using avidin and biotin
JPH0825888B2 (ja) * 1986-01-30 1996-03-13 フレッド ハッチンソン キャンサ− リサ−チ センタ− 免疫選択法
US5225353A (en) * 1986-01-30 1993-07-06 Fred Hutchinson Cancer Research Center Method for immunoselection of cells using avidin and biotin
US4798795A (en) * 1987-02-17 1989-01-17 Hoechst Celanese Corporation Biotinylating agents
US5006464A (en) * 1987-10-01 1991-04-09 E-Y Laboratories, Inc. Directed flow diagnostic device and method
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices

Also Published As

Publication number Publication date
EP0526577A1 (en) 1993-02-10
DE69105497D1 (de) 1995-01-12
DK0526577T3 (da) 1995-05-15
CA2081202A1 (en) 1991-10-24
WO1991016088A1 (en) 1991-10-31
US5378624A (en) 1995-01-03
CA2081202C (en) 2000-03-21
EP0526577B1 (en) 1994-11-30
JPH05507792A (ja) 1993-11-04
JP2721040B2 (ja) 1998-03-04
DE69105497T2 (de) 1995-04-06
ATE114484T1 (de) 1994-12-15

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