ES2065745T3 - Sintesis de compuestos de 1alfa-hidroxi-secosterol. - Google Patents

Sintesis de compuestos de 1alfa-hidroxi-secosterol.

Info

Publication number
ES2065745T3
ES2065745T3 ES92302077T ES92302077T ES2065745T3 ES 2065745 T3 ES2065745 T3 ES 2065745T3 ES 92302077 T ES92302077 T ES 92302077T ES 92302077 T ES92302077 T ES 92302077T ES 2065745 T3 ES2065745 T3 ES 2065745T3
Authority
ES
Spain
Prior art keywords
1alfa
hydroxy
synthesis
secosterol
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92302077T
Other languages
English (en)
Inventor
Hector F Deluca
Heinrich K Schnoes
Kato L Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/667,440 external-priority patent/US5089641A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2065745T3 publication Critical patent/ES2065745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE UN NUEVO METODO PARA LA PRODUCCION DE COMPUESTOS DE SECOSTEROL Y, EN PARTICULAR, A LA PREPARACION DE 1O-HIDROXI-HOMOPREGNACALCIFEROL QUE ES UN COMPUESTO DE SECOSTEROL EFICAZ PARA INDUCIR LA DIFERENCIACION DE CELULAS MALIGNAS Y POR TANTO ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO LA LEUCEMIA.
ES92302077T 1991-03-11 1992-03-11 Sintesis de compuestos de 1alfa-hidroxi-secosterol. Expired - Lifetime ES2065745T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/667,440 US5089641A (en) 1991-03-11 1991-03-11 Synthesis of 1α-hydroxy-secosterol compounds
US83701092A 1992-02-14 1992-02-14

Publications (1)

Publication Number Publication Date
ES2065745T3 true ES2065745T3 (es) 1995-02-16

Family

ID=27099682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92302077T Expired - Lifetime ES2065745T3 (es) 1991-03-11 1992-03-11 Sintesis de compuestos de 1alfa-hidroxi-secosterol.

Country Status (6)

Country Link
EP (1) EP0503923B1 (es)
JP (1) JP2793428B2 (es)
AT (1) ATE116292T1 (es)
CA (1) CA2062520C (es)
DE (1) DE69200980T2 (es)
ES (1) ES2065745T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5763234A (en) * 1996-07-25 1998-06-09 Florida Atlantic University Secosteroids, and method for producing same
CA2588060A1 (en) * 2004-11-22 2006-06-01 Wisconsin Alumni Research Foundation 2-methylene-19-nor-(20s)-1alpha-hydroxy-trishomopregnacalciferol
ES2358914T3 (es) * 2004-11-22 2011-05-16 Wisconsin Alumni Research Foundation 2-metileno-19,21-dinor-1alfa-hidroxi-bishomopregnacalciferol.
WO2006057913A2 (en) 2004-11-22 2006-06-01 Wisconsin Alumni Research Foundation 2-METHYLENE-19-NOR-(20R)-1-α-HYDROXY-BISHOMOPREGNACALCIFEROL

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67153A (en) * 1981-11-02 1986-12-31 Res Inst Medicine Chem Intermediates in the production of vitamin d analogues and method for their production
EP0154185B1 (en) * 1984-02-08 1988-10-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Calciferol derivatives
EP0218714B1 (en) * 1985-04-23 1991-08-07 Wisconsin Alumni Research Foundation Seco-sterol compounds effective in inducing the differentiation of malignant cells
JP2642189B2 (ja) * 1989-03-23 1997-08-20 株式会社クラレ ステロイド誘導体及びその製造方法
EP0402982B1 (en) * 1989-06-15 1994-01-05 Duphar International Research B.V Adduct-aldehyde and its use for the preparation of a vitamin-D compound
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i

Also Published As

Publication number Publication date
CA2062520C (en) 1998-08-11
CA2062520A1 (en) 1992-09-12
JP2793428B2 (ja) 1998-09-03
ATE116292T1 (de) 1995-01-15
EP0503923A1 (en) 1992-09-16
DE69200980T2 (de) 1995-05-11
EP0503923B1 (en) 1994-12-28
DE69200980D1 (de) 1995-02-09
JPH0597796A (ja) 1993-04-20

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