ATE116292T1 - Synthese von 1-alpha-hydroxy- secosterinverbindungen. - Google Patents
Synthese von 1-alpha-hydroxy- secosterinverbindungen.Info
- Publication number
- ATE116292T1 ATE116292T1 AT92302077T AT92302077T ATE116292T1 AT E116292 T1 ATE116292 T1 AT E116292T1 AT 92302077 T AT92302077 T AT 92302077T AT 92302077 T AT92302077 T AT 92302077T AT E116292 T1 ATE116292 T1 AT E116292T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- hydroxy
- synthesis
- secosterol
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- DIFSFFZHWQSHBX-CLECVEASSA-N (1ar,3s,4as,7s,8as)-3-[(1s,2r,3r)-3-[(2r,5s)-5,6-dimethylheptan-2-yl]-2-(2-hydroxyethyl)-2-methylcyclopentyl]-7-hydroxy-4a-methyl-2,3,5,6,7,8-hexahydro-1ah-naphtho[4,4a-b]oxiren-4-one Chemical class OCC[C@]1(C)[C@@H]([C@H](C)CC[C@H](C)C(C)C)CC[C@H]1[C@H]1C(=O)[C@@]2(C)CC[C@H](O)C[C@@]32O[C@@H]3C1 DIFSFFZHWQSHBX-CLECVEASSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 secosterol compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/667,440 US5089641A (en) | 1991-03-11 | 1991-03-11 | Synthesis of 1α-hydroxy-secosterol compounds |
| US83701092A | 1992-02-14 | 1992-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE116292T1 true ATE116292T1 (de) | 1995-01-15 |
Family
ID=27099682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92302077T ATE116292T1 (de) | 1991-03-11 | 1992-03-11 | Synthese von 1-alpha-hydroxy- secosterinverbindungen. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0503923B1 (de) |
| JP (1) | JP2793428B2 (de) |
| AT (1) | ATE116292T1 (de) |
| CA (1) | CA2062520C (de) |
| DE (1) | DE69200980T2 (de) |
| ES (1) | ES2065745T3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5763234A (en) * | 1996-07-25 | 1998-06-09 | Florida Atlantic University | Secosteroids, and method for producing same |
| US7541348B2 (en) * | 2004-11-22 | 2009-06-02 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol |
| EP1827452B1 (de) | 2004-11-22 | 2011-03-02 | Wisconsin Alumni Research Foundation | 2-methylen-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol |
| JP2008520708A (ja) | 2004-11-22 | 2008-06-19 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−（２０Ｒ）−１α−ヒドロキシ−ビスホモプレグナカルシフェロール |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0078704B1 (de) * | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Zwischenprodukte in der Synthese von Vitamin D Derivaten |
| IL74264A (en) * | 1984-02-08 | 1988-08-31 | Hoffmann La Roche | Preparation of calciferol derivatives,certain such novel compounds and pharmaceutical compositions containing them |
| EP0218714B1 (de) * | 1985-04-23 | 1991-08-07 | Wisconsin Alumni Research Foundation | Die differenzierung maligner zellen bewirkende seco-sterol-verbindungen |
| JP2642189B2 (ja) * | 1989-03-23 | 1997-08-20 | 株式会社クラレ | ステロイド誘導体及びその製造方法 |
| DK0402982T3 (da) * | 1989-06-15 | 1994-02-14 | Duphar Int Res | Adductaldehyd og dets anvendelse til fremstilling af vitamin-D-forbindelser |
| GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
-
1992
- 1992-03-09 CA CA002062520A patent/CA2062520C/en not_active Expired - Lifetime
- 1992-03-11 DE DE69200980T patent/DE69200980T2/de not_active Expired - Lifetime
- 1992-03-11 JP JP4087659A patent/JP2793428B2/ja not_active Expired - Lifetime
- 1992-03-11 EP EP92302077A patent/EP0503923B1/de not_active Expired - Lifetime
- 1992-03-11 ES ES92302077T patent/ES2065745T3/es not_active Expired - Lifetime
- 1992-03-11 AT AT92302077T patent/ATE116292T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2062520C (en) | 1998-08-11 |
| DE69200980D1 (de) | 1995-02-09 |
| ES2065745T3 (es) | 1995-02-16 |
| DE69200980T2 (de) | 1995-05-11 |
| EP0503923B1 (de) | 1994-12-28 |
| JP2793428B2 (ja) | 1998-09-03 |
| EP0503923A1 (de) | 1992-09-16 |
| CA2062520A1 (en) | 1992-09-12 |
| JPH0597796A (ja) | 1993-04-20 |
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