ES2065906T3 - Produccion de proteinas en formas activas. - Google Patents

Produccion de proteinas en formas activas.

Info

Publication number
ES2065906T3
ES2065906T3 ES88301257T ES88301257T ES2065906T3 ES 2065906 T3 ES2065906 T3 ES 2065906T3 ES 88301257 T ES88301257 T ES 88301257T ES 88301257 T ES88301257 T ES 88301257T ES 2065906 T3 ES2065906 T3 ES 2065906T3
Authority
ES
Spain
Prior art keywords
protein
protein production
active forms
rupturing
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88301257T
Other languages
English (en)
Inventor
Joseph John Patroni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Cross Biotech Pty Ltd
Original Assignee
Southern Cross Biotech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Cross Biotech Pty Ltd filed Critical Southern Cross Biotech Pty Ltd
Application granted granted Critical
Publication of ES2065906T3 publication Critical patent/ES2065906T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

UN METODO PARA LA PREPARACION DE UNA PROTEINA EN UNA FORMA FISIOLOGICAMENTE ACTIVA O NATURAL, COMPRENDE PREPARAR UNA FUENTE DE PROTEINA EN FORMA SOLUBILIZADA Y UN AGENTE CAPAZ DE VENCER LAS FUERZAS ATOMICAS EN EL INTERIOR DE LA MOLECULA, Y PONER EN CONTACTO LA PROTEINA CON EL AGENTE PARA CONVERTIRLA A UNA FORMA FISIOLOGICAMENTE ACTIVA. EL AGENTE DE SEPARACION SE ELIGE ENTRE UREA O UNO DE SUS DERIVADOS, DIMETILSULFONA Y SUS MEZCLAS.
ES88301257T 1987-02-20 1988-02-16 Produccion de proteinas en formas activas. Expired - Lifetime ES2065906T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPI046287 1987-02-20

Publications (1)

Publication Number Publication Date
ES2065906T3 true ES2065906T3 (es) 1995-03-01

Family

ID=3772028

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88301257T Expired - Lifetime ES2065906T3 (es) 1987-02-20 1988-02-16 Produccion de proteinas en formas activas.

Country Status (10)

Country Link
US (1) US4966963A (es)
EP (1) EP0279619B1 (es)
JP (1) JPS63264598A (es)
AT (1) ATE114319T1 (es)
AU (1) AU612133B2 (es)
CA (1) CA1326106C (es)
DE (1) DE3852140T2 (es)
ES (1) ES2065906T3 (es)
NZ (1) NZ223559A (es)
ZA (1) ZA881067B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
AU609824B2 (en) * 1987-06-15 1991-05-09 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
JPH03500601A (ja) * 1987-06-26 1991-02-14 コモンウェルス　サイエンティフィック　アンド　インダストリアル　リサーチ　オーガナイゼイション ウィルス中和及び保護モノクローナル抗体により認識されるｉｂｄｖ　ｖｐ２エピトープ
US5136027A (en) * 1989-05-02 1992-08-04 Abbott Laboratories Method for renaturing proteins in the presence of alkyl sulfate detergents
US5101018A (en) * 1989-06-12 1992-03-31 International Minerals & Chemical Corp. Method for recovering recombinant proteins
EP0432419B1 (en) * 1989-12-05 1994-10-19 American Cyanamid Company Method for solubilization and naturation of somatotropins utilizing low urea concentration
ES2119779T3 (es) * 1990-09-05 1998-10-16 Southern Cross Biotech Pty Ltd Solubilizacion de proteinas en formas activas.
US6566098B1 (en) * 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
GB2281558B (en) * 1993-09-07 1997-02-19 Joseph Matthew Gaugas Supplying sulphur to plants
US5861372A (en) * 1996-02-22 1999-01-19 The Children's Medical Center Corporation Aggregate angiostatin and method of use
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US5840838A (en) * 1996-02-29 1998-11-24 University Of Kentucky Research Foundation Process for enhancing the activity of amyloid β peptides
US20030190307A1 (en) * 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
EP2158923B1 (en) 1998-08-06 2013-02-27 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CN102807973A (zh) 2005-04-11 2012-12-05 萨文特医药公司 尿酸氧化酶的变体形式及其用途
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
WO2008051178A2 (en) 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
DK3321359T3 (da) 2005-04-11 2021-03-08 Horizon Pharma Rheumatology Llc Variante former af uratoxidase og anvendelse deraf
JP2008545665A (ja) * 2005-05-23 2008-12-18 ユニベルシテ ドゥ ジュネーブ 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
US9388406B2 (en) 2008-11-17 2016-07-12 Cornell University System useful for reporting protein-protein interactions in the bacterial periplasm
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
EP3538135A4 (en) 2016-11-11 2020-07-29 Horizon Pharma Rheumatology LLC POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2829089A1 (de) * 1977-07-13 1979-02-01 Sandoz Ag Subunit-vakzine
US4462940A (en) * 1982-09-23 1984-07-31 Cetus Corporation Process for the recovery of human β-interferon-like polypeptides
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
US4731440A (en) * 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4766224A (en) * 1985-08-19 1988-08-23 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
AU597924B2 (en) * 1985-12-11 1990-06-14 Natinco Nv Solubilization of protein aggregates
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
AU607988B2 (en) * 1987-04-21 1991-03-21 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
AU1763188A (en) * 1987-06-15 1988-12-15 Bunge (Australia) Pty Ltd Recovery of proteins in active form

Also Published As

Publication number Publication date
CA1326106C (en) 1994-01-11
ZA881067B (en) 1988-08-11
US4966963A (en) 1990-10-30
EP0279619A2 (en) 1988-08-24
EP0279619B1 (en) 1994-11-23
ATE114319T1 (de) 1994-12-15
DE3852140D1 (de) 1995-01-05
EP0279619A3 (en) 1990-04-11
DE3852140T2 (de) 1995-04-06
JPS63264598A (ja) 1988-11-01
AU1141288A (en) 1988-08-25
NZ223559A (en) 1989-09-27
AU612133B2 (en) 1991-07-04

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