ES2066113T3 - Complejos de dtpa derivados, agentes farmaceuticos que contienen estos compuestos, su empleo y procedimiento para su produccion. - Google Patents

Complejos de dtpa derivados, agentes farmaceuticos que contienen estos compuestos, su empleo y procedimiento para su produccion.

Info

Publication number
ES2066113T3
ES2066113T3 ES90250165T ES90250165T ES2066113T3 ES 2066113 T3 ES2066113 T3 ES 2066113T3 ES 90250165 T ES90250165 T ES 90250165T ES 90250165 T ES90250165 T ES 90250165T ES 2066113 T3 ES2066113 T3 ES 2066113T3
Authority
ES
Spain
Prior art keywords
compounds
derivative
procedure
production
pharmaceutical agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90250165T
Other languages
English (en)
Inventor
Heribert Dr Schmitt-Willich
Johannes Dr Platzek
Heinz Dr Gries
Gabriele D Schuhmann-Giampieri
Hubert Dr Vogler
Hanns-Joachim Dr Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6384290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2066113(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2066113T3 publication Critical patent/ES2066113T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/94—Bismuth compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL INVENTO TRATA DE COMPUESTOS DE FORMULA (I), SUS SALES CON BASES ORGANICAS E INORGANICOS, AMINOACIDOS AMIDAS DE AMINOACIDOS Y DESCRIBE LA APLICACION DEL COMPUESTOS DE FORMULA (I) COMO MEDIO FARMACEUTICO. SIENDO; R HIDROGENO OR1, UN RESTO ALQUILO DE C1 A 6 O UN GRUPO CH2-COOR1-G; R1 HIDROGENO, UN RESTO ALQUILO DE C1 A 6 O UN GRUPO ALQUILO DE C1 A 6 O UN GRUPO BENCILO; X HIDROGENO Y/O EQUIVALENTE DE IONES METALICOS DE UNOS ELEMENTOS (21-2-44, 57-83); Z1 Y Z2 HIDROGENO O EL RESTO -(CH2)M-(C6H4)Q-(O)K-(CH2)N-(6H4); -(OR)-R; M Y N UN NUMERO DE 0 A 20 Y K, L, Q Y R UN NUMERO DE 0 A 1.
ES90250165T 1989-06-30 1990-06-27 Complejos de dtpa derivados, agentes farmaceuticos que contienen estos compuestos, su empleo y procedimiento para su produccion. Expired - Lifetime ES2066113T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3922005A DE3922005A1 (de) 1989-06-30 1989-06-30 Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES2066113T3 true ES2066113T3 (es) 1995-03-01

Family

ID=6384290

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90250165T Expired - Lifetime ES2066113T3 (es) 1989-06-30 1990-06-27 Complejos de dtpa derivados, agentes farmaceuticos que contienen estos compuestos, su empleo y procedimiento para su produccion.

Country Status (24)

Country Link
EP (1) EP0405704B1 (es)
JP (1) JP2603357B2 (es)
KR (1) KR100190808B1 (es)
AT (1) ATE115546T1 (es)
AU (1) AU637111B2 (es)
CA (1) CA2020142C (es)
CZ (1) CZ277926B6 (es)
DD (1) DD296276B5 (es)
DE (3) DE3922005A1 (es)
DK (1) DK0405704T3 (es)
ES (1) ES2066113T3 (es)
FI (1) FI102168B (es)
HK (1) HK1002810A1 (es)
HU (1) HU210208B (es)
IE (1) IE65676B1 (es)
IL (1) IL94818A (es)
NL (1) NL300182I2 (es)
NO (2) NO179203C (es)
NZ (1) NZ234295A (es)
PT (1) PT94541B (es)
RU (1) RU2086554C1 (es)
TW (1) TW219356B (es)
UA (1) UA27275C2 (es)
ZA (1) ZA905129B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE4302289A1 (de) * 1993-01-25 1994-07-28 Schering Ag Verfahren zur Herstellung C-substituierter Diethylentriamine
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
DE4341724A1 (de) * 1993-12-03 1995-06-08 Schering Ag Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
EP0794800A1 (de) * 1994-11-30 1997-09-17 Schering Aktiengesellschaft Verwendung von chelatverbindungen als leber- und gallen-röntgendiagnostika
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (es) 1995-02-01 1997-11-11 Epix Medical Inc
DE19606326A1 (de) * 1995-02-09 1996-08-22 Schering Ag Kontrastmittelhaltige Liposomenformulierung sowie deren Verwendung für die In-vivo-Diagnostik, insbesondere für die Darstellung des Intravasalraumes
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
JP2759627B2 (ja) * 1995-07-21 1998-05-28 東北大学長 非エステル結合性ｄｔｐａ誘導体およびその製造方法
DE19641197C2 (de) * 1996-09-24 1999-02-18 Schering Ag Ionenpaare und ihre Verwendung als Kontrastmittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
DE19712012A1 (de) * 1997-03-13 1998-09-24 Schering Ag Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6-9-tris(carboxymethyl)-4-(4- ethoxybenzyl)-undecandisäure
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
US6534040B2 (en) * 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
KR100749087B1 (ko) * 2006-06-02 2007-08-14 경북대학교 산학협력단 신규한 ｄｔｐａ-비스-아미드 리간드들 및 이들이 결합된가돌리늄 착물
SE533165C2 (sv) * 2008-06-13 2010-07-13 Chemseq Internat Ab Kemikalie och förfarande för komplexbindning av metalljoner, som är minst tvåvärda
EP2338874A1 (en) * 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
DE102010023890A1 (de) 2010-06-11 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecandinsäure und die Verwendung zur Herstellung von Primovist
EP2580184A2 (de) 2010-06-11 2013-04-17 Bayer Intellectual Property GmbH Verfahren zur herstellung kristalliner 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)-undecandisäure und die verwendung zur herstellung von primovist®
CN104761461A (zh) * 2014-09-09 2015-07-08 山东富创医药科技有限公司 一种新的钆塞酸二钠中间体的制备方法
US11149041B2 (en) * 2016-05-30 2021-10-19 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of gadolinium complex of (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium (Gadoxetate disodium)
JP6867639B2 (ja) * 2016-10-11 2021-05-12 学校法人 聖マリアンナ医科大学 非イオン性ヨード造影剤の結合体
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
CS9003174A2 (en) 1991-11-12
CA2020142C (en) 2001-04-17
DD296276B5 (de) 1995-11-02
EP0405704A3 (en) 1991-03-27
IE902299A1 (en) 1991-01-16
ATE115546T1 (de) 1994-12-15
JP2603357B2 (ja) 1997-04-23
PT94541B (pt) 1997-02-28
HU210208B (en) 1995-02-28
DE122004000051I2 (de) 2011-12-29
DE59007987D1 (de) 1995-02-02
CZ277926B6 (en) 1993-06-16
NO179203B (no) 1996-05-20
NL300182I2 (nl) 2005-08-01
JPH03215457A (ja) 1991-09-20
DE122004000051I1 (de) 2005-04-21
EP0405704A2 (de) 1991-01-02
UA27275C2 (uk) 2000-09-15
NO179203C (no) 1996-08-28
IE65676B1 (en) 1995-11-15
NO902925L (no) 1991-01-02
ZA905129B (en) 1991-04-24
IE902299L (en) 1990-12-30
AU5802490A (en) 1991-01-03
HK1002810A1 (zh) 1998-09-18
KR100190808B1 (ko) 1999-06-01
NZ234295A (en) 1993-02-25
NO902925D0 (no) 1990-06-29
FI102168B1 (fi) 1998-10-30
EP0405704B1 (de) 1994-12-14
FI102168B (fi) 1998-10-30
KR910000134A (ko) 1991-01-29
DE3922005A1 (de) 1991-01-10
IL94818A (en) 1996-05-14
HUT54622A (en) 1991-03-28
HU904040D0 (en) 1990-12-28
NL300182I1 (nl) 2005-06-01
AU637111B2 (en) 1993-05-20
NO2005013I2 (no) 2006-06-19
IL94818A0 (en) 1991-04-15
RU2086554C1 (ru) 1997-08-10
FI903295A0 (fi) 1990-06-29
DK0405704T3 (da) 1995-02-20
TW219356B (es) 1994-01-21
CA2020142A1 (en) 1990-12-31
PT94541A (pt) 1991-02-08

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