ES2066794T3 - Polietilenglicolcarbaminatos. - Google Patents

Polietilenglicolcarbaminatos.

Info

Publication number
ES2066794T3
ES2066794T3 ES88810484T ES88810484T ES2066794T3 ES 2066794 T3 ES2066794 T3 ES 2066794T3 ES 88810484 T ES88810484 T ES 88810484T ES 88810484 T ES88810484 T ES 88810484T ES 2066794 T3 ES2066794 T3 ES 2066794T3
Authority
ES
Spain
Prior art keywords
formula
carbaminates
polyethylene glycol
rest
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88810484T
Other languages
English (en)
Inventor
Heinrich Dr Peter
Theophile Moerker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2066794T3 publication Critical patent/ES2066794T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

COMPUESTO DE FORMULA (I). SIENDO A1, A2, A3 INDEPENDIENTES UNOS DE OTROS REPRESENTA HIDROGENO O UN RESTO ACILO; R ALQUILO CON HASTA CUATRO ATOMOS DE CARBONO; X UN RESTO DE LA FORMULA (II); M UN NUMERO DE 0 A 1; N UN NUMERO DE 0 A 9. EL GRUPO CARBONILO PUEDE LIGARSE CON EL OXIGENO O CON EL HIDROGENO. ADEMAS SE OBTIENE LAS SALES DEL COMPUESTO DE FORMULA (I) Y ASI COMO COMPLEJOS METALICOS DE DICHOS COMPUESTOS DE FORMULA (I). SE EMPLEAN COMO QUELATOS METALICOS O COMO MEDIOS DE AYUDA EN DIAGNOSTICOS.
ES88810484T 1987-07-23 1988-07-15 Polietilenglicolcarbaminatos. Expired - Lifetime ES2066794T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH279487 1987-07-23

Publications (1)

Publication Number Publication Date
ES2066794T3 true ES2066794T3 (es) 1995-03-16

Family

ID=4241735

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88810484T Expired - Lifetime ES2066794T3 (es) 1987-07-23 1988-07-15 Polietilenglicolcarbaminatos.

Country Status (21)

Country Link
US (3) US5185368A (es)
EP (1) EP0300969B1 (es)
JP (1) JPH0813795B2 (es)
KR (1) KR890002250A (es)
AT (1) ATE117328T1 (es)
AU (1) AU617677B2 (es)
DD (1) DD281810A5 (es)
DE (1) DE3852793D1 (es)
DK (1) DK410988A (es)
ES (1) ES2066794T3 (es)
FI (1) FI93351C (es)
HU (1) HU201517B (es)
IE (1) IE65550B1 (es)
IL (1) IL87184A (es)
MX (1) MX12394A (es)
NO (1) NO171684C (es)
NZ (1) NZ225506A (es)
PH (1) PH26779A (es)
PT (1) PT88060B (es)
YU (1) YU142188A (es)
ZA (1) ZA885336B (es)

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ES2052771T3 (es) * 1987-07-23 1994-07-16 Ciba Geigy Ag Procedimiento para la n-acilacion selectiva de derivados del acido amino-hidroxamico y los productos de partida empleados en el mismo.
MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
DE58901673D1 (de) * 1988-06-08 1992-07-23 Ciba Geigy Ag Carbamoylierte hydroxamsaeurederivate und verfahren zu ihrer herstellung.
US5324844A (en) * 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
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US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5310539A (en) * 1991-04-15 1994-05-10 Board Of Regents, The University Of Texas System Melanin-based agents for image enhancement
US5254724A (en) * 1991-10-30 1993-10-19 University Of Florida Research Foundation, Inc. Method for synthesis of desferrioxamine B, analogs and homologs thereof
GB9211779D0 (en) * 1992-06-03 1992-07-15 Ciba Geigy Ag Amine salts
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5489491A (en) * 1992-07-22 1996-02-06 Golovin; Milton N. Curable polymer precursors for solid electrolytes
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
ES2244367T3 (es) 1993-04-22 2005-12-16 Emisphere Technologies, Inc. Composiciones para la administracion por via oral.
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5618838A (en) * 1993-06-18 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Gallium complexes for the treatment of free radical-induced diseases
IL106064A (en) * 1993-06-18 1997-11-20 Yissum Res Dev Co Gallium complexes for the treatment of free radical-induced diseases
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
WO1997010197A1 (en) 1995-09-11 1997-03-20 Emisphere Technologies, Inc. METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES
AU2595697A (en) 1996-03-29 1997-10-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7026116B1 (en) * 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6140305A (en) 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
AU3828597A (en) 1996-06-14 1998-01-07 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
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US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
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US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
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US8454934B2 (en) * 2006-05-25 2013-06-04 Canadian Blood Services High molecular weight chelation structure
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RU2354390C2 (ru) * 2007-05-15 2009-05-10 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук ГУ НИИ фармакологии ТНЦ СО РАМН Осмотический диуретик, обладающий антитоксическим действием при отравлении алифатическими спиртами
CN102438657A (zh) * 2009-03-26 2012-05-02 沃萨乌整形外科公司 鉴别定向药物递送组合物的潜在组分的方法
KR20180105701A (ko) * 2016-02-11 2018-09-28 모데차이 체비온 신경변성의 치료를 위한 방법 및 약학 조성물
CN115109045A (zh) * 2022-07-14 2022-09-27 大连大学 一种生物基杂环单体及其均聚酯的制备方法

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DK107752C (da) * 1960-10-11 1967-07-03 Ciba Geigy Fremgangsmåde til fremstilling af trihydroxamsyrer eller salt eller metalkomplekser deraf.
US3471476A (en) * 1964-05-18 1969-10-07 Tino Gaeumann Trihydroxamic acids
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MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
EP0325559B1 (de) * 1988-01-20 1993-12-15 Ciba-Geigy Ag Verfahren zur Herstellung von Komplexverbindungen
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Also Published As

Publication number Publication date
HU201517B (en) 1990-11-28
YU142188A (en) 1990-04-30
NO171684B (no) 1993-01-11
FI883470A7 (fi) 1989-01-24
FI93351C (fi) 1995-03-27
FI883470A0 (fi) 1988-07-22
EP0300969A2 (de) 1989-01-25
DK410988A (da) 1989-01-24
IE882249L (en) 1989-01-23
FI93351B (fi) 1994-12-15
EP0300969A3 (en) 1990-12-19
IE65550B1 (en) 1995-11-01
MX12394A (es) 1993-12-01
PT88060A (pt) 1989-06-30
JPH0813795B2 (ja) 1996-02-14
DK410988D0 (da) 1988-07-22
DD281810A5 (de) 1990-08-22
US5185368A (en) 1993-02-09
KR890002250A (ko) 1989-04-10
PT88060B (pt) 1995-03-01
JPS6447749A (en) 1989-02-22
US5328992A (en) 1994-07-12
ATE117328T1 (de) 1995-02-15
NZ225506A (en) 1990-12-21
AU1929088A (en) 1989-01-27
AU617677B2 (en) 1991-12-05
US5424057A (en) 1995-06-13
DE3852793D1 (de) 1995-03-02
PH26779A (en) 1992-10-13
EP0300969B1 (de) 1995-01-18
NO883246L (no) 1989-01-24
HUT47529A (en) 1989-03-28
IL87184A0 (en) 1988-12-30
NO883246D0 (no) 1988-07-21
ZA885336B (en) 1989-03-29
IL87184A (en) 1993-04-04
NO171684C (no) 1993-04-21

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