ES2067150T3 - Sistema de suministro de drogas bioelastomericas. - Google Patents

Sistema de suministro de drogas bioelastomericas.

Info

Publication number
ES2067150T3
ES2067150T3 ES91302648T ES91302648T ES2067150T3 ES 2067150 T3 ES2067150 T3 ES 2067150T3 ES 91302648 T ES91302648 T ES 91302648T ES 91302648 T ES91302648 T ES 91302648T ES 2067150 T3 ES2067150 T3 ES 2067150T3
Authority
ES
Spain
Prior art keywords
polymer
physiological condition
functional group
composition
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91302648T
Other languages
English (en)
Inventor
Dan W Urry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioelastics Research Ltd
Original Assignee
Bioelastics Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioelastics Research Ltd filed Critical Bioelastics Research Ltd
Application granted granted Critical
Publication of ES2067150T3 publication Critical patent/ES2067150T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2045—Polyamides; Polyaminoacids, e.g. polylysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION DE DISTRIBUCION DE MEDICAMENTO, QUE CONTIENE UN POLIMERO BIOELASTICO, QUE CONTIENE UNIDADES MONOMERICAS SELECCIONADAS DEL GRUPO FORMADO POR PENTOPEPTIDOS BIOELASTICOS, TETRAPEPTIDOS Y MONOPEPTIDOS, Y UN MEDICAMENTO RETENIDO POR EL POLIMERO, DONDE EL POLIMERO SE SELECCIONA PARA ESTAR EN UN PRIMER ESTADO DE CONTRACCION, ELEGIDO ENTRE EL GRUPO FORMADO POR ESTADOS DE BIELASTOMEROS CONTRAIDOS Y RELAJADOS, CUANDO SE PONEN EN CONTACTO CON UNA CONDICION FISIOLOGICA PRESENTE EN UN HUMANO O UN ANIMAL AL QUE SE ADMINISTRA LA COMPOSICION Y DONDE EL POLIMERO CONTIENE UN GRUPO FUNCIONAL REACTIVO QUE SUFRE UNA REACCION, BIEN EN PRESENCIA DE LA CONDICION FISIOLOGICA CUANDO EL POLIMERO ES TRANSPORTADO POR UN PROCESO NATURAL EN EL HOMBRE O EL ANIMAL A UNA POSICION DIFERENTE CON UNA CONDICION FISIOLOGICAL DIFERENTE, PARA PRODUCIR UN SEGUNDO GRUPO FUNCIONAL, DONDE LA PRESENCIA DEL SEGUNDO GRUPO FUNCIONAL HACE QUE EL POLIMERO CAMBIE AL OTRO DE LOS ESTADOS DE CONTRACCION, HACIENDO ASI AL MEDICAMENTO DISPONIBLE PARA LIBERARSE DE LA COMPOSICION.
ES91302648T 1990-03-27 1991-03-26 Sistema de suministro de drogas bioelastomericas. Expired - Lifetime ES2067150T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49969790A 1990-03-27 1990-03-27

Publications (1)

Publication Number Publication Date
ES2067150T3 true ES2067150T3 (es) 1995-03-16

Family

ID=23986317

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91302648T Expired - Lifetime ES2067150T3 (es) 1990-03-27 1991-03-26 Sistema de suministro de drogas bioelastomericas.

Country Status (6)

Country Link
US (1) US6328996B1 (es)
EP (1) EP0449592B1 (es)
JP (1) JPH0729942B2 (es)
AT (1) ATE114458T1 (es)
DE (1) DE69105323T2 (es)
ES (1) ES2067150T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20007A (sl) * 1996-11-27 2000-02-29 Guenther Beisel Sredstvo za ustvarjanje dolgotrajnega učinka sitosti
GB9718463D0 (en) * 1997-08-29 1997-11-05 Dynal As Biomolecules
AU2798599A (en) * 1998-02-27 1999-09-15 Bioelastics Research Ltd. Injectable implants for tissue augmentation and restoration
WO2000056774A1 (en) * 1999-03-19 2000-09-28 Duke University Methods of using bioelastomers
US20050255554A1 (en) * 2000-03-20 2005-11-17 Ashutosh Chilkoti Fusion peptides isolatable by phase transition
US6852834B2 (en) 2000-03-20 2005-02-08 Ashutosh Chilkoti Fusion peptides isolatable by phase transition
ATE295155T1 (de) 2001-10-05 2005-05-15 Surmodics Inc Beschichtungen mit immobilisierten partikeln sowie verwendungen derselben
AU2003212955A1 (en) * 2002-02-07 2003-09-02 Rutgers, The State University Of New Jersey Therapeutic polyesters and polyamides
GB0412631D0 (en) * 2004-06-07 2004-07-07 Cambridge Applied Polymers Ltd Polymer release system
EP1812480A4 (en) * 2004-10-14 2010-11-03 Tufts College ELECTROCHEMICAL DEGRADABLE POLYMERS
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
EP3725299A1 (en) 2005-06-24 2020-10-21 Duke University A direct drug delivery system based on thermally responsive biopolymers
CN101384272B (zh) 2005-12-20 2013-05-01 杜克大学 用于递送具有增强的药理性质的活性剂的方法和组合物
US20130172274A1 (en) * 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US20090098110A1 (en) * 2007-05-30 2009-04-16 Duke University Injectable forms of solid-forming crosslinked bioelastic biopolymers for local drug delivery
EP3412300A1 (en) * 2008-06-27 2018-12-12 Duke University Therapeutic agents comprising elastin-like peptides
DK3311828T3 (da) 2009-08-14 2021-06-28 Phasebio Pharmaceuticals Inc Modificerede vasoaktive tarmpeptider
WO2012170524A1 (en) 2011-06-06 2012-12-13 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
WO2014081849A1 (en) 2012-11-20 2014-05-30 Phasebio Pharmaceuticals, Inc. Formulations of active agents for sustained release
WO2015172046A1 (en) 2014-05-08 2015-11-12 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
KR101975743B1 (ko) * 2016-04-07 2019-05-09 한양대학교 에리카산학협력단 신혈관 생성 억제를 위한 혈관내피성장인자 수용체 타겟팅 펩타이드-엘라스틴 융합 폴리펩타이드 및 자가조립 나노구조체

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867520A (en) * 1971-04-14 1975-02-18 Ajinomoto Kk Medicated polyamino acid film for occlusive dressing therapy
US3888975A (en) * 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US4178361A (en) * 1973-09-10 1979-12-11 Union Corporation Sustained release pharmaceutical composition
FR2353282A1 (fr) * 1976-06-02 1977-12-30 Invap Etablissement Application de l'elastine et de ses derives en cosmetique
US4187852A (en) * 1976-07-09 1980-02-12 The University Of Alabama Synthetic elastomeric insoluble cross-linked polypentapeptide
DE3104815C2 (de) * 1980-02-13 1983-07-07 Japan Atomic Energy Research Institute, Tokyo Verfahren zur Herstellung eines Verbundstoffs mit Langzeit-Freigabe
US4474851A (en) * 1981-10-02 1984-10-02 The University Of Alabama In Birmingham Elastomeric composite material comprising a polypeptide
US4605413A (en) 1983-09-19 1986-08-12 The University Of Alabama At Birmingham Stimulation of chemotaxis by chemotactic peptides
US4589882A (en) * 1983-09-19 1986-05-20 Urry Dan W Enzymatically crosslinked bioelastomers
US4671954A (en) * 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
US4863735A (en) * 1985-02-19 1989-09-05 Massachusetts Institute Of Technology Biodegradable polymeric drug delivery system with adjuvant activity
US4693718A (en) * 1985-10-31 1987-09-15 University Of Alabama In Birmingham Stimulation of chemotaxis by chemotactic peptides
US4741872A (en) * 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US4898926A (en) * 1987-06-15 1990-02-06 The University Of Alabama At Birmingham/Research Foundation Bioelastomer containing tetra/penta-peptide units
ATE84710T1 (de) * 1988-06-30 1993-02-15 Centre Nat Rech Scient Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln.

Also Published As

Publication number Publication date
DE69105323T2 (de) 1995-06-01
EP0449592A1 (en) 1991-10-02
JPH0729942B2 (ja) 1995-04-05
EP0449592B1 (en) 1994-11-30
ATE114458T1 (de) 1994-12-15
DE69105323D1 (de) 1995-01-12
JPH04221323A (ja) 1992-08-11
US6328996B1 (en) 2001-12-11

Similar Documents

Publication Publication Date Title
ES2067150T3 (es) Sistema de suministro de drogas bioelastomericas.
ES2074050T3 (es) Sistema de liberacion.
MX9100249A (es) Sistema para suministrar medicamentos y proceso para preparar el mismo
ES2009346A6 (es) Procedimiento de preparacion de composiciones farmaceuticas que contienen polipeptidos hidroinsolubles.
ATE285813T1 (de) Stent mit arzneistoffabgabe
DK88385A (da) Biologisk nedbrydeligt polypeptid samt anvendelse deraf til gradvis frigivelse af laegemidler
NO884474D0 (no) Implanterbart, biologisk nedbrytbart virkestoff-frigjoeringssystem.
NZ504026A (en) Methods for treating hypercoagulable states or acquired protein C deficiency using human-activated protein C
FI872490A0 (fi) Doseringsformer med foerdroejd frigivning.
DE69434963D1 (de) Selektiv auf die leber wirkende pharmazeutisch aktive substanz
ES2065461T3 (es) Unidades de administracion de un farmaco de liberacion constante.
DE3783257D1 (de) Peptid, dessen verfahren zur herstellung, sie enthaltende pharmazeutische zusammensetzung und benutzung.
DE3763851D1 (de) System zur arzneistoffabgabe mit erhoehter bioakzeptanz.
ES2097145T3 (es) Metodo y dispositivo para la liberacion de farmacos en la piel.
SE9202208D0 (sv) Vaevnadsfoerstaerkning
ATE91622T1 (de) In einer zur erhoehung ihrer loeslichkeitsrate geeigneten form auf polymere substanzen aufgebrachte schwerloesliche arzneistoffe.
YU108691A (sh) Nove 3,3'-ditiobis (propionske kiseline) i njihovi estri
JPS6456055A (en) Medical molded article composed of lactic acid/epsilon-caprolactone copolymer and its preparation
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
ATE96025T1 (de) Verwendung von dapiprazol zur herstellung eines arzneimittels zur verhinderung des toleranzentwicklung bei der analgetischen behandlung mit morphin.
Noble Failure of cefotaxime in the treatment of Yersinia enterocolitica sepsis despite in vitro susceptibility.
Das et al. Effects of barium on cellular systems-- a review.
CA2070252A1 (en) A polymeric article such as a medical catheter and method for making the same
MY100419A (en) Sanitary article
KR930700109A (ko) 신경 질환 치료용 4,4'-[9h-플루오렌-9-일리덴비스(메틸렌)]-비스피리미딘

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 449592

Country of ref document: ES