ES2067743T3 - Dispositivo y metodo para liberar un farmaco iontoforeticamente. - Google Patents

Dispositivo y metodo para liberar un farmaco iontoforeticamente.

Info

Publication number
ES2067743T3
ES2067743T3 ES90907649T ES90907649T ES2067743T3 ES 2067743 T3 ES2067743 T3 ES 2067743T3 ES 90907649 T ES90907649 T ES 90907649T ES 90907649 T ES90907649 T ES 90907649T ES 2067743 T3 ES2067743 T3 ES 2067743T3
Authority
ES
Spain
Prior art keywords
agent
ions
molecular weight
deposit
electrolyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907649T
Other languages
English (en)
Inventor
Ronald P Haak
J Richard Gyory
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26781412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2067743(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2067743T3 publication Critical patent/ES2067743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

SE PRESENTA UNA MEMBRANA SELECTIVAMENTE PERMEABLE (14) QUE SE SITUA ENTRE UN DEPOSITO DE UN AGENTE (15) Y EL ELECTRODO (11) DE UNA ESTRUCTURA (8) DE ELECTRODO DONANTE EN UN DISPOSITIVO DE LIBERACION IONTOFORETICA. OPCIONALMENTE, EL DEPOSITO DE ELECTROLITO (13) SE SITUA ENTRE EL ELECTRODO Y EL DEPOSITO DEL AGENTE (15). EN CIERTAS CONFORMACIONES, LA MEMBRANA (14) ES PERMEABLE A ESPECIES MENORES A UN PESO MOLECULAR PREDETERMINADO Y SUBSTANCIALMENTE MENOS PERMEABLE A ESPECIES DE UN PESO MOLECULAR MAYOR QUE EL PREDETERMINADO. EL AGENTE ES CAPAZ DE DISOCIARSE EN IONES DEL AGENTE Y CONTRAIONES. LA SELECTIVIDAD DE TAMAÑO DE LA MEMBRANA (14), EL PESO MOLECULAR DE LOS IONES DEL AGENTE, EL PESO MOLECULAR DE LOS CONTRAIONES, Y OPCIONALMENTE EL PESO MOLECULAR DE LOS IONES DEL ELECTROLITO SE SELECCIONAN PARA (A) EVITAR QUE LOS IONES DEL AGENTE INTERACTUEN CON EL ELECTRODO (11), Y QUE PENETREN EN EL INTERIOR DEL DEPOSITO DEL ELECTROLITO (13), EN DONDE, DE OTRA FORMA, PODRIAN DEGRADARSE Y (B) PARA EVITAR QUE LOS IONES DEL ELECTROLITO, QUE TENGAN UNA CARGA SIMILAR A LOS IONES DEL AGENTE, PENETREN EN EL INTERIOR DEL DEPOSITO DEL AGENTE (15) Y COMPITAN CON LOS IONES DEL AGENTE EN EL SUMINISTRO IONTOFORETICO AL PACIENTE.
ES90907649T 1988-10-03 1990-04-30 Dispositivo y metodo para liberar un farmaco iontoforeticamente. Expired - Lifetime ES2067743T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/252,463 US4927408A (en) 1988-10-03 1988-10-03 Electrotransport transdermal system
PCT/US1990/002414 WO1991016943A1 (en) 1988-10-03 1990-04-30 Device and method of iontophoretic drug delivery

Publications (1)

Publication Number Publication Date
ES2067743T3 true ES2067743T3 (es) 1995-04-01

Family

ID=26781412

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907649T Expired - Lifetime ES2067743T3 (es) 1988-10-03 1990-04-30 Dispositivo y metodo para liberar un farmaco iontoforeticamente.

Country Status (10)

Country Link
US (1) US4927408A (es)
EP (1) EP0528789B1 (es)
AT (1) ATE114486T1 (es)
AU (1) AU644792B2 (es)
DE (1) DE69014653T2 (es)
DK (1) DK0528789T3 (es)
ES (1) ES2067743T3 (es)
FI (1) FI924918A7 (es)
NO (1) NO924127D0 (es)
WO (1) WO1991016943A1 (es)

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AU644792B2 (en) 1993-12-23
WO1991016943A1 (en) 1991-11-14
ATE114486T1 (de) 1994-12-15
AU5634090A (en) 1991-11-27
FI924918A0 (fi) 1992-10-29
EP0528789A1 (en) 1993-03-03
DE69014653T2 (de) 1995-04-06
DK0528789T3 (da) 1995-05-01
EP0528789B1 (en) 1994-11-30
DE69014653D1 (de) 1995-01-12
FI924918A7 (fi) 1992-10-29

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