ES2068253T3 - Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas. - Google Patents

Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas.

Info

Publication number
ES2068253T3
ES2068253T3 ES89312875T ES89312875T ES2068253T3 ES 2068253 T3 ES2068253 T3 ES 2068253T3 ES 89312875 T ES89312875 T ES 89312875T ES 89312875 T ES89312875 T ES 89312875T ES 2068253 T3 ES2068253 T3 ES 2068253T3
Authority
ES
Spain
Prior art keywords
thiazolidin
cataracts
treatment
aliphatic
carbons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89312875T
Other languages
English (en)
Inventor
William H Garner
Larry A Wheeler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ES2068253T3 publication Critical patent/ES2068253T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION FACILITA EL USO DE UN COMPUESTO DE LA FORMULA: R ES HIDROGENO, HIDROXILO, ALIFATICO(C1-20), (CH2)N-Q, EN DONDE N ES 0-20 Y Q ES FENILO, TIENILO, FURILO, PIRIDILO O (CH2)N-T EN DONDE N ES 0-20 Y T ES UN ANILLO ALIFATICO DE 3 A 7 ATOMOS DE CARBONO, O =0 O UN CETAL DE 2 A 5 ATOMOS DE CARBONO, O HIDROXILO, U O-ALIFATICO (C1-10), O N(R1)2 EN DONDE R1 ES HIDROGENO O ALQUILO DE 1 A 5 ATOMOS DE CARBONO, O TIAZOLIDINA, O UN AZUCAR; Y Z ES -OH O UNA SAL FARMACEUTICAMENTE ACEPTABLE, OR3 EN DONDE R3 ES UN GRUPO ALIFATICO DE 1 A 10 ATOMOS DE CARBONO, N(R1)2 CUANDO R1 SEA HIDROGENO O ALQUILO DE 1 A 5 ATOMOS DE CARBONO, EN LA PREPARACION DE UN MEDICAMENTO QUE RETRASA LA APARICION DE CATARATAS EN MAMIFEROS.
ES89312875T 1988-12-09 1989-12-11 Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas. Expired - Lifetime ES2068253T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28276788A 1988-12-09 1988-12-09

Publications (1)

Publication Number Publication Date
ES2068253T3 true ES2068253T3 (es) 1995-04-16

Family

ID=23083041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89312875T Expired - Lifetime ES2068253T3 (es) 1988-12-09 1989-12-11 Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas.

Country Status (6)

Country Link
US (1) US5399573A (es)
EP (1) EP0373002B1 (es)
JP (1) JPH02202818A (es)
AT (1) ATE119038T1 (es)
DE (1) DE68921436T2 (es)
ES (1) ES2068253T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2092539T3 (es) * 1991-01-10 1996-12-01 Transcend Therapeutics Inc Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares.
US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5208249A (en) * 1992-08-20 1993-05-04 Clintec Nutrition Co. Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate
JPH09505057A (ja) * 1993-11-19 1997-05-20 ザ・ユニバーシティ・オブ・シドニー 白内障を予防または制御するための方法
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
US5624955A (en) * 1995-05-03 1997-04-29 Regents Of The University Of Minnesota Compounds that enhance the concentration of glutathione in tissues
US5576278A (en) * 1995-06-07 1996-11-19 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use
US5686450A (en) * 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
US5846988A (en) * 1996-03-25 1998-12-08 Alcon Laboratories, Inc. Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents
HRP20241559T1 (hr) 2016-05-18 2025-02-14 Sound Pharmaceuticals Incorporated Ebselen za uporabu u liječenju menierove bolesti

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474817A (en) * 1980-02-29 1984-10-02 Massachusetts Institute Of Technology Process for preventing or reversing cataract formation
US4351826A (en) * 1980-02-29 1982-09-28 Massachusetts Institute Of Technology Process for preventing or reversing cataract formation using acrylamides
US4526789A (en) * 1980-02-29 1985-07-02 Massachusetts Institute Of Technology Process for preventing or reversing cataract formation
JPS5718615A (en) * 1980-07-07 1982-01-30 Senjiyu Seiyaku Kk Anticataract agent
US4665082A (en) * 1981-02-11 1987-05-12 Cornell Research Foundation Cysteine delivery system
US4335210A (en) * 1981-02-11 1982-06-15 Cornell Research Foundation Method of producing L-cysteine
US4647571A (en) * 1981-02-11 1987-03-03 Cornell Research Foundation Cysteine delivery composition
US4438124A (en) * 1981-02-11 1984-03-20 Cornell Research Foundation, Inc. Cysteine delivery system
US4434158A (en) * 1981-02-11 1984-02-28 Cornell Research Foundation Cysteine delivery system
US5091421A (en) * 1987-06-04 1992-02-25 Massachusetts Institute Of Technology Chemical prevention or reversal of cataract by phase separation inhibitors

Also Published As

Publication number Publication date
EP0373002B1 (en) 1995-03-01
US5399573A (en) 1995-03-21
DE68921436D1 (de) 1995-04-06
DE68921436T2 (de) 1995-08-10
JPH02202818A (ja) 1990-08-10
EP0373002A3 (en) 1991-07-31
EP0373002A2 (en) 1990-06-13
ATE119038T1 (de) 1995-03-15

Similar Documents

Publication Publication Date Title
ES2068253T3 (es) Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas.
KR900701815A (ko) 피리미딘 유도체
NO903438L (no) Fremgangsmaate for fremstilling av tiazolderivater.
KR920002608A (ko) 라파마이신 유도체
NO170008C (no) Analogifremgangsmaate ved fremstilling av tetralinestere av fenoler eller benzonsyrer med retinoidliknende aktivitet
GB1502082A (en) Orthoester polymers
FI921522A0 (fi) Pyrazolopyridinfoerening och foerfarande foer dess framstaellning.
TW206970B (es)
AU7772994A (en) Cyclic amino acid derivatives
DE69019404D1 (de) Derivate von Penciclovir zur Behandlung von Hepatitis-B-Infektionen.
AU3624089A (en) Analgesic phenothiazine derivatives
KR890009901A (ko) 3-히드록시-2-(4-메톡시페닐)-5-(2-메틸아미노에틸)-2,3-디히드로-5h-1,5- 벤조티아제핀-4-온 유도체, 그의 제조 및 치료에의 이용
DE3750464D1 (de) Pharmazeutisches Präparat zur Behandlung des Katarakts.
KR890012942A (ko) 5-치환된 오르니틴 유도체
ES467948A1 (es) Un procedimiento para la preparacion de un derivado de fe- nilpiperazina.
FI893099A0 (fi) Menetelmä lääkeaineena käyttökelpoisen glyserolijohdannaisen valmistamiseksi
ES2077345T3 (es) Intermediarios del grupo mureidomicina, su preparacion y su uso.
KR920007626A (ko) 벤조[b]티오펜-2-카르복시이미드아미드 유도체의 사용방법
ATE58141T1 (de) 1-hydroxy-5-oxo-5h-pyrido(3,2-a>-phenoxazin-3carbons|ureester.
FR2663026B1 (fr) Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
PT728002E (pt) Utilizacao de derivados de 2-amino purina para o tratamento e profilaxia da infeccao pelo virus de herpes 7 humano
DE69026098D1 (de) Organogermaniumderivate enthaltende Zubereitungen zur therapeutischen Verwendung
NO167382C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-hydroxy-4-(substituerte alkenyl)cyklohexancarboxylsyrer.
KR930700496A (ko) 약물학적 활성을 갖는 s-(2-테노일)-티오젖산 유도체

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 373002

Country of ref document: ES