ES2068345T3 - Antagonistas del receptor del fibrinogeno. - Google Patents

Antagonistas del receptor del fibrinogeno.

Info

Publication number
ES2068345T3
ES2068345T3 ES90311151T ES90311151T ES2068345T3 ES 2068345 T3 ES2068345 T3 ES 2068345T3 ES 90311151 T ES90311151 T ES 90311151T ES 90311151 T ES90311151 T ES 90311151T ES 2068345 T3 ES2068345 T3 ES 2068345T3
Authority
ES
Spain
Prior art keywords
fibrinogen receptor
receptor antagonists
fibrinogen
antagonist
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90311151T
Other languages
English (en)
Inventor
Ruth F Nutt
Stephen F Brady
Daniel F Veber
Mark E Duggan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23669678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2068345(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2068345T3 publication Critical patent/ES2068345T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60D—VEHICLE CONNECTIONS
    • B60D1/00—Traction couplings; Hitches; Draw-gear; Towing devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Transportation (AREA)
  • Mechanical Engineering (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN ANTAGONISTA DEL RECEPTOR FIBRINOGENO DE LA FORMULA EN DONDE XX REPRESENTA UN ACIDO ALFA-AMINO SINTETICO QUE CONTIENE UNA CADENA SECUNDARIA LINEAL Y ZZ REPRESENTA UNA SECUENCIA DE ACIDOS AMINO 1,2,3 O 4.
ES90311151T 1989-10-13 1990-10-11 Antagonistas del receptor del fibrinogeno. Expired - Lifetime ES2068345T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42122489A 1989-10-13 1989-10-13

Publications (1)

Publication Number Publication Date
ES2068345T3 true ES2068345T3 (es) 1995-04-16

Family

ID=23669678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90311151T Expired - Lifetime ES2068345T3 (es) 1989-10-13 1990-10-11 Antagonistas del receptor del fibrinogeno.

Country Status (16)

Country Link
EP (1) EP0422938B1 (es)
JP (1) JP2914582B2 (es)
KR (1) KR910007704A (es)
AT (1) ATE118783T1 (es)
AU (1) AU634294B2 (es)
CA (1) CA2027315A1 (es)
DE (1) DE69017138T2 (es)
DK (1) DK0422938T3 (es)
ES (1) ES2068345T3 (es)
FI (1) FI905022A7 (es)
IE (1) IE65197B1 (es)
IL (1) IL95917A (es)
NO (1) NO904431L (es)
NZ (1) NZ235563A (es)
PT (1) PT95582B (es)
ZA (1) ZA908156B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686569A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
ATE188387T1 (de) * 1991-02-08 2000-01-15 Diatide Inc Technetium-99m markierte polypeptide zur bildformung
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0667783B1 (en) * 1991-11-07 1999-04-21 The University Of Southern California Compositions and methods for preventing adhesion formation
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
WO1994007918A1 (en) * 1992-10-02 1994-04-14 Diatech, Inc. Multimeric polyvalent antithrombotic agents
JPH08503217A (ja) * 1992-11-18 1996-04-09 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 血小板糖タンパク質▲ＩＩ▼ｂ／▲ＩＩＩ▼ａの阻害剤として有用な複素環式環により結合された環状化合物
NZ265753A (en) * 1993-03-29 1996-11-26 Du Pont Merck Pharma Preparation of platelet glycoprotein iib/iiia inhibitors containing methylarginine
ZA942439B (en) * 1993-04-08 1996-01-08 Diatech Inc Radiolabeled compounds for thrombus imaging
CA2193828A1 (en) * 1994-06-29 1996-01-11 Timothy P. Kogan Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
GB9524630D0 (en) * 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
EP0842195A1 (en) * 1995-07-06 1998-05-20 Zeneca Limited Peptide inhibitors of fibronectine
GB9613112D0 (en) 1996-06-21 1996-08-28 Zeneca Ltd Chemical compounds
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
EP1063973B1 (en) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
KR20010087125A (ko) * 1998-04-16 2001-09-15 데이비드 비. 맥윌리암스 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6435397B2 (en) 2000-04-18 2002-08-20 Progressive Tool & Industries Co. Robotic turntable
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CN107080846A (zh) 2010-07-09 2017-08-22 詹姆斯.特林卡.格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统
US10875875B2 (en) 2017-04-26 2020-12-29 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3781263T2 (de) * 1986-12-15 1993-04-08 Inst Nat Sante Rech Med Peptid-derivate und deren verwendung in der therapie.
ES2102367T3 (es) * 1990-05-18 1997-08-01 Hoechst Ag Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion.

Also Published As

Publication number Publication date
IE65197B1 (en) 1995-10-04
JP2914582B2 (ja) 1999-07-05
IL95917A0 (en) 1991-07-18
NZ235563A (en) 1993-04-28
IE903665A1 (en) 1991-04-24
IL95917A (en) 1998-02-08
EP0422938A1 (en) 1991-04-17
DE69017138D1 (de) 1995-03-30
ATE118783T1 (de) 1995-03-15
ZA908156B (en) 1991-07-31
FI905022A7 (fi) 1991-04-14
AU634294B2 (en) 1993-02-18
PT95582B (pt) 1999-02-26
KR910007704A (ko) 1991-05-30
FI905022A0 (fi) 1990-10-12
AU6457390A (en) 1991-04-18
JPH03173897A (ja) 1991-07-29
DE69017138T2 (de) 1995-09-28
NO904431L (no) 1991-04-15
CA2027315A1 (en) 1991-04-14
NO904431D0 (no) 1990-10-12
PT95582A (pt) 1991-09-13
DK0422938T3 (da) 1995-05-01
EP0422938B1 (en) 1995-02-22

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