ES2069914T3 - Agentes marcadores que comprenden conjugados de acidos boronicos. - Google Patents

Agentes marcadores que comprenden conjugados de acidos boronicos.

Info

Publication number
ES2069914T3
ES2069914T3 ES91920019T ES91920019T ES2069914T3 ES 2069914 T3 ES2069914 T3 ES 2069914T3 ES 91920019 T ES91920019 T ES 91920019T ES 91920019 T ES91920019 T ES 91920019T ES 2069914 T3 ES2069914 T3 ES 2069914T3
Authority
ES
Spain
Prior art keywords
acid conjugates
hemoglobin
boronic acid
agents including
marketing agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920019T
Other languages
English (en)
Inventor
Frank Frantzen
Erling Sundrehagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axis Biochemicals AS
Original Assignee
Axis Biochemicals AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axis Biochemicals AS filed Critical Axis Biochemicals AS
Application granted granted Critical
Publication of ES2069914T3 publication Critical patent/ES2069914T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN AGENTES ETIQUETADORES QUE COMPRENDEN CONJUGADOS DE ACIDO BORICO NO PROTEINACEOS QUE TIENEN UNA ABSORCION MAXIMA NO MENOR DE 600 NM, DICHA ETIQUETA SE OBTIENE MEDIANTE UN COLORANTE DE POR EJEMPLO AZINA, TRIFENILMETANO, CIANINA O FTALOCIANINA, LOS AGENTES SON UTILES EN LA ESTIMACION Y CUANTIFICACION DE CISDIOLES TALES COMO LA HEMOGLOBINA GLICOSILADA, EN VIRTUD DE LA SUBSTANCIALMENTE TOTAL AUSENCIA DE SUPERPOSICION CON EL ESPECTRO DE ABSORCION DE LA HEMOGLOBINA. LOS COLORANTES DE OXACINA Y TIACINA, QUE EXHIBEN SIMILARES CARACTERISTICAS DE ABSORCION Y QUE CONTIENEN OTRAS MOLECULAS ACTIVADAS SON SIMILARMENTE UTILES COMO AGENTES ETIQUETADORES, ESPECIALMENTE EN LA PRESENCIA DE HEMOGLOBINA.
ES91920019T 1990-11-14 1991-11-13 Agentes marcadores que comprenden conjugados de acidos boronicos. Expired - Lifetime ES2069914T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909024775A GB9024775D0 (en) 1990-11-14 1990-11-14 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2069914T3 true ES2069914T3 (es) 1995-05-16

Family

ID=10685377

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920019T Expired - Lifetime ES2069914T3 (es) 1990-11-14 1991-11-13 Agentes marcadores que comprenden conjugados de acidos boronicos.

Country Status (16)

Country Link
US (1) US5739318A (es)
EP (1) EP0557357B1 (es)
JP (1) JP2761494B2 (es)
AT (1) ATE120195T1 (es)
AU (1) AU666294B2 (es)
CA (1) CA2096251C (es)
DE (1) DE69108403T2 (es)
DK (1) DK0557357T3 (es)
ES (1) ES2069914T3 (es)
FI (1) FI105549B (es)
GB (1) GB9024775D0 (es)
HU (1) HU216635B (es)
NO (1) NO304691B1 (es)
PL (1) PL176747B1 (es)
RU (1) RU2076127C1 (es)
WO (1) WO1992008722A1 (es)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
EP0596700A1 (en) * 1992-11-03 1994-05-11 Hewlett-Packard Company Cis-diol detection method and solid supports
US5395752A (en) * 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
ATE217087T1 (de) * 1993-03-19 2002-05-15 Novartis Ag Chemilumineszierende derivate mit langer emissionswellenlänge und ihre verwendung in assays
US5623055A (en) * 1994-01-28 1997-04-22 Prolinx, Inc. Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US5777148A (en) * 1994-01-28 1998-07-07 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
US5852178A (en) * 1994-01-28 1998-12-22 Prolinx, Inc. Phenylboronic acid complexing reagents for conjugating biologically active molecules
PT741734E (pt) * 1994-01-28 2001-09-28 Prolinx Inc Complexos de acido fenilboronico
US5847192A (en) * 1994-01-28 1998-12-08 Prolinx, Inc. Boronic compound complexing reagents and complexes
US5837878A (en) * 1994-01-28 1998-11-17 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US5744627A (en) * 1994-01-28 1998-04-28 Prolinx, Inc. Boronic compound complexing reagents and complexes
US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
US5880279A (en) * 1995-07-31 1999-03-09 Chevron U.S.A. Inc. Cobalt dihalodihydroxydisulfophthalocyanines
US6156884A (en) * 1996-08-05 2000-12-05 Prolinx, Inc. Bifunctional boronic compound complexing reagents and complexes
US6075126A (en) * 1996-08-05 2000-06-13 Prolinx, Inc. Phenyldiboronic acid reagents and complexes
DE19721399A1 (de) * 1997-05-22 1998-11-26 Basf Ag Phthalocyanine und ihre Verwendung als Markierungsmittel
DE19843094A1 (de) 1998-09-21 2000-03-23 Roche Diagnostics Gmbh Verfahren zur Bestimmung von glykiertem Hämoglobin
EP1163372A4 (en) * 1999-03-24 2002-10-02 Princeton Separations CHEMICALLY REACTIVE CYANINE DYES AND DERIVATIVES IN A LEVEL
RU2183635C2 (ru) * 1999-11-26 2002-06-20 Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Сульфозамещенные фталоцианины как фотосенсибилизаторы для фотодинамической терапии
CA2419238A1 (en) * 2000-08-16 2002-02-21 University Of Alberta Non-pressurized methods for the preparation of conjugated solid supports for boronic acids
EP1213328A1 (de) * 2000-12-08 2002-06-12 Evotec OAI AG Oxazinderivate
EP1317511B1 (de) * 2000-09-06 2005-01-19 Evotec OAI AG Oxazinderivate
US6627177B2 (en) 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US7470420B2 (en) 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
GB0110053D0 (en) * 2001-04-24 2001-06-13 Axis Shield Asa Assay
WO2002099077A2 (en) * 2001-06-06 2002-12-12 Proteologics, Inc. Methods and compositions related to tagging of membrane surface proteins
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7390670B2 (en) * 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US7427129B2 (en) * 2004-02-04 2008-09-23 Hewlett-Packard Development Company, L.P. Boronic acid containing dyes to improve permanence of images
CN101541813B (zh) * 2006-11-30 2013-07-31 医药及科学传感器公司 耐氧化的指示剂分子
GB0903348D0 (en) * 2009-02-27 2009-04-08 Pharmalucia Ltd Compounds and methods relating thereto
EP4086605B1 (en) 2011-06-17 2025-06-11 Roche Diagnostics Hematology, Inc. Solution and method for histoprocessing of biological samples
GB201215571D0 (en) 2012-08-31 2012-10-17 Axis Shield Asa Assay method
EP3375777A1 (en) * 2017-03-15 2018-09-19 MIKROCHEM spol. s.r.o. Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
EP0319620A1 (en) * 1987-12-10 1989-06-14 Viomedics Inc. Novel oxazines-ureas and thiazine urea chromophors
US4830786A (en) * 1986-02-27 1989-05-16 Syntex (U.S.A.) Inc. Squaraine dyes
DE3720736A1 (de) * 1987-06-23 1989-01-05 Erwin Dr Schleicher Verfahren, reagenzien und ausruestung zur einfachen bestimmung von nicht-enzymatisch glykosylierten proteinen in koerperfluessigkeiten
US4861728A (en) * 1987-07-24 1989-08-29 Becton, Dickinson And Company Immunoassay of glycosylated hemoglobin using a labeled boron reagent
EP0310361A3 (en) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Tridentate conjugate and method of use thereof
DE3827340A1 (de) * 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
DE3840452A1 (de) * 1988-12-01 1990-06-07 Hoechst Ag (beta)-amino-boronsaeure-derivate
DE3843605A1 (de) * 1988-12-23 1990-06-28 Hoechst Ag Wasserloesliche faserreaktive farbstoffe, verfahren zu ihrer herstellung und ihre verwendung
NO890029D0 (no) * 1989-01-04 1989-01-04 Axis Research Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes).
JPH02226070A (ja) * 1989-02-27 1990-09-07 Fuji Photo Film Co Ltd 糖タンパク質の定量方法
US5071531A (en) * 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5227475A (en) * 1989-05-10 1993-07-13 Hoechst Aktiengesellschaft Water-soluble fiber-reactive dyestuffs containing a cyanamido-substituted triazinylamino-grouping, and a process for dyeing with the use of these dyes
DE69108439T2 (de) * 1990-05-01 1995-07-27 Nacalai Tesque Inc Verfahren zur Bestimmung des Glykationsprozentsatzes eines bestimmten Proteins.

Also Published As

Publication number Publication date
FI105549B (fi) 2000-09-15
US5739318A (en) 1998-04-14
HU216635B (hu) 1999-07-28
HU9301408D0 (en) 1993-09-28
EP0557357A1 (en) 1993-09-01
FI932149L (fi) 1993-06-10
EP0557357B1 (en) 1995-03-22
FI932149A0 (fi) 1993-05-12
DK0557357T3 (da) 1995-06-12
GB9024775D0 (en) 1991-01-02
AU8909291A (en) 1992-06-11
ATE120195T1 (de) 1995-04-15
WO1992008722A1 (en) 1992-05-29
CA2096251A1 (en) 1992-05-15
JP2761494B2 (ja) 1998-06-04
CA2096251C (en) 1999-08-17
NO304691B1 (no) 1999-02-01
DE69108403T2 (de) 1995-08-17
RU2076127C1 (ru) 1997-03-27
DE69108403D1 (de) 1995-04-27
HUT64353A (en) 1993-12-28
JPH06502170A (ja) 1994-03-10
NO931746L (no) 1993-07-13
NO931746D0 (no) 1993-05-13
PL176747B1 (pl) 1999-07-30
AU666294B2 (en) 1996-02-08

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