ES2070334T3 - Procedimiento para la preparacion de derivados de progesterona. - Google Patents

Procedimiento para la preparacion de derivados de progesterona.

Info

Publication number
ES2070334T3
ES2070334T3 ES90913165T ES90913165T ES2070334T3 ES 2070334 T3 ES2070334 T3 ES 2070334T3 ES 90913165 T ES90913165 T ES 90913165T ES 90913165 T ES90913165 T ES 90913165T ES 2070334 T3 ES2070334 T3 ES 2070334T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
progesterone derivatives
progesterone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90913165T
Other languages
English (en)
Inventor
Helmut Dr Hauser
Hans Detlef Dr Berndt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2070334T3 publication Critical patent/ES2070334T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE TRATA DE UN PROCESO PARA LA PRODUCCION DE DERIVADOS DE LA PROGESTERONA SEGUN LA FORMULA GENERAL (I), EN LA QUE ... ES UNA UNION SIMPLE O DOBLE, X ES UN ATOMO DE HIDROGENO O DE FLUOR O UN GRUPO METILO Y V ES UN GRUPO METILENO, ETILIDENO O VINILIDENO.
ES90913165T 1989-09-14 1990-09-06 Procedimiento para la preparacion de derivados de progesterona. Expired - Lifetime ES2070334T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931064A DE3931064A1 (de) 1989-09-14 1989-09-14 Verfahren zur herstellung von progesteron-derivaten

Publications (1)

Publication Number Publication Date
ES2070334T3 true ES2070334T3 (es) 1995-06-01

Family

ID=6389636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90913165T Expired - Lifetime ES2070334T3 (es) 1989-09-14 1990-09-06 Procedimiento para la preparacion de derivados de progesterona.

Country Status (10)

Country Link
US (1) US5132440A (es)
EP (1) EP0443000B1 (es)
JP (1) JP2837271B2 (es)
AT (1) ATE117695T1 (es)
CA (1) CA2041644A1 (es)
DD (1) DD297651A5 (es)
DE (2) DE3931064A1 (es)
ES (1) ES2070334T3 (es)
MX (1) MX172229B (es)
WO (1) WO1991004265A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103467555A (zh) * 2013-03-29 2013-12-25 山东新华制药股份有限公司 17α-羟基黄体酮的合成方法
CN104072565B (zh) * 2014-07-11 2017-03-01 山东众诚药业股份有限公司 一种高收率的17α‑羟基黄体酮的简捷制备方法
CN104119415B (zh) * 2014-08-06 2017-01-25 湖南科瑞生物制药股份有限公司 一种17a‑羟基黄体酮的制备方法
CN107286215A (zh) * 2016-03-31 2017-10-24 天津金耀集团有限公司 一种多个烯烃基团的甾体化合物制备方法
CN105801651B (zh) * 2016-04-19 2018-03-06 浙江仙居君业药业有限公司 一种17α‑羟基黄体酮的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2082129A5 (es) * 1970-03-04 1971-12-10 Roussel Uclaf
EP0153001B1 (en) * 1984-02-03 1992-03-11 The Upjohn Company Steroids having an enamide or enimide group and their preparation
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
US4831131A (en) * 1984-02-03 1989-05-16 The Upjohn Company 11β,17α-Dihydroxy-17β-cyano-androstanes
DE3427486A1 (de) * 1984-07-23 1986-01-30 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von 6(alpha)-methylsteroiden

Also Published As

Publication number Publication date
ATE117695T1 (de) 1995-02-15
US5132440A (en) 1992-07-21
DE59008362D1 (de) 1995-03-09
EP0443000A1 (de) 1991-08-28
EP0443000B1 (de) 1995-01-25
WO1991004265A1 (de) 1991-04-04
MX172229B (es) 1993-12-08
JPH04501861A (ja) 1992-04-02
JP2837271B2 (ja) 1998-12-14
DD297651A5 (de) 1992-01-16
DE3931064A1 (de) 1991-03-28
CA2041644A1 (en) 1991-03-15

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