ES2070972T3 - Procedimiento para la preparacion de 17-esteres de 21-desoxiprednisolona. - Google Patents

Procedimiento para la preparacion de 17-esteres de 21-desoxiprednisolona.

Info

Publication number
ES2070972T3
ES2070972T3 ES90120426T ES90120426T ES2070972T3 ES 2070972 T3 ES2070972 T3 ES 2070972T3 ES 90120426 T ES90120426 T ES 90120426T ES 90120426 T ES90120426 T ES 90120426T ES 2070972 T3 ES2070972 T3 ES 2070972T3
Authority
ES
Spain
Prior art keywords
esters
desoxyprednisolone
sulphonate
formula
desoxiprednisolona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90120426T
Other languages
English (en)
Inventor
Tadatoshi Kuriyama
Masaki Ogawa
Susumu Sato
Naokata Taido
Tadayuki Kuraishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Application granted granted Critical
Publication of ES2070972T3 publication Critical patent/ES2070972T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCUBRE UN PROCESO PARA PREPARAR 21-DESOXYPREDNISOLONE 17-ESTERS DE LA FORMULA (IV) EL PROCESO COMPRENDE REACCIONAR UN ORTHOESTER PREDNISOLONE 17 (ALFA), 21 CICLICO, CON UN ACIDO EN UNA BAJA SOLUCION DE ALCOHOL DEL 40 UNA PREDNISOLONE 17-ESTER 21-SULFONATO, Y REACCIONANDO EL SULFONATO CON UN YODURO METALICO ALCALINO EN METHYL ETHYL KETONE, EN LA PRESENCIA DE UN BAJO ACIDO GRASO PARA PRODUCIR EL COMPUESTO DE LA FORMULA (IV). EL PROCESO ASEGURA UNA ECONOMICA PRODUCCION INDUSTRIAL DE ALTA PUREZA DE 21-DESOXYPREDNISOLONE 17-ESTERS, UNA EXCELENTE MEDICINA ANTI-INFLAMATORIA LOCAL, DE ALTO RENDIMIENTO POR PROCEDIMIENTOS SIMPLES
ES90120426T 1989-10-26 1990-10-24 Procedimiento para la preparacion de 17-esteres de 21-desoxiprednisolona. Expired - Lifetime ES2070972T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1279188A JPH07116222B2 (ja) 1989-10-26 1989-10-26 ２１―デスオキシプレドニゾロン―１７―エステルの製造法

Publications (1)

Publication Number Publication Date
ES2070972T3 true ES2070972T3 (es) 1995-06-16

Family

ID=17607666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90120426T Expired - Lifetime ES2070972T3 (es) 1989-10-26 1990-10-24 Procedimiento para la preparacion de 17-esteres de 21-desoxiprednisolona.

Country Status (7)

Country Link
US (1) US5159091A (es)
EP (1) EP0424921B1 (es)
JP (1) JPH07116222B2 (es)
KR (1) KR950004902B1 (es)
CA (1) CA2027627C (es)
DE (1) DE69016922T2 (es)
ES (1) ES2070972T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102964414A (zh) * 2012-12-14 2013-03-13 中国科学院上海有机化学研究所 17位甾体羧酸酯的合成方法
CN103665078B (zh) * 2013-12-18 2016-06-08 成都医路康医学技术服务有限公司 一种17α-羟基甾体酯的制备方法
CN104356188A (zh) * 2014-10-23 2015-02-18 华中药业股份有限公司 一种丁酸氢化可的松的制备方法
CN107556357A (zh) * 2017-09-28 2018-01-09 湖南科瑞生物制药股份有限公司 丙酸地泼罗酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499081A (en) * 1966-12-21 1970-03-03 Squibb & Sons Inc 9-chloroprogestational agents
US3639434A (en) 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
US3856956A (en) 1967-02-02 1974-12-24 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
US3980680A (en) 1975-08-14 1976-09-14 Schering Corporation Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein
DE2645104C2 (de) * 1976-10-04 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen 11β-Hydroxy-1,4,8-pregnatrien-3,20-dion-Derivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CA2027627A1 (en) 1991-04-27
DE69016922T2 (de) 1995-09-28
KR950004902B1 (ko) 1995-05-15
US5159091A (en) 1992-10-27
DE69016922D1 (de) 1995-03-23
EP0424921A2 (en) 1991-05-02
KR910007956A (ko) 1991-05-30
EP0424921A3 (en) 1991-12-04
JPH03141294A (ja) 1991-06-17
EP0424921B1 (en) 1995-02-15
CA2027627C (en) 2000-12-05
JPH07116222B2 (ja) 1995-12-13

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