ES2071628T3 - Separacion de proteina a de preparaciones de anticuerpos. - Google Patents

Separacion de proteina a de preparaciones de anticuerpos.

Info

Publication number
ES2071628T3
ES2071628T3 ES89109455T ES89109455T ES2071628T3 ES 2071628 T3 ES2071628 T3 ES 2071628T3 ES 89109455 T ES89109455 T ES 89109455T ES 89109455 T ES89109455 T ES 89109455T ES 2071628 T3 ES2071628 T3 ES 2071628T3
Authority
ES
Spain
Prior art keywords
protein
antibody preparations
antibody
protein separation
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89109455T
Other languages
English (en)
Inventor
James W Bloom
Melvin F Wong
Gautam Mitra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22756428&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2071628(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ES2071628T3 publication Critical patent/ES2071628T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE AISLA LA PROTEINA SELECTIVAMENTE DE UN ANTICUERPO - MEZCLA DE PROTEINA POR EXPOSICION DE LA MEZCLA A UN MATERIAL DE INTERCAMBIO DE ANIONES BAJO CONDICIONES SUFICIENTES PARA ABSORBER AMBOS COMPONENTES Y ENTONCES ELUDIR LOS ANTICUERPOS DE PROTEINA A BAJO CONDICIONES DE AUMENTO DE LA FUERZA IONICO. LAS PREPARACIONES DE ANTICUERPO RESULTANTES TIENEN MENOS DE 15 MG DE PROTEINA A POR MG DE ANTICUERPO.
ES89109455T 1988-06-08 1989-05-25 Separacion de proteina a de preparaciones de anticuerpos. Expired - Lifetime ES2071628T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/204,054 US4983722A (en) 1988-06-08 1988-06-08 Removal of protein A from antibody preparations

Publications (1)

Publication Number Publication Date
ES2071628T3 true ES2071628T3 (es) 1995-07-01

Family

ID=22756428

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89109455T Expired - Lifetime ES2071628T3 (es) 1988-06-08 1989-05-25 Separacion de proteina a de preparaciones de anticuerpos.

Country Status (7)

Country Link
US (1) US4983722A (es)
EP (1) EP0345549B1 (es)
JP (1) JP2664478B2 (es)
AT (1) ATE121752T1 (es)
CA (1) CA1339188C (es)
DE (1) DE68922338T2 (es)
ES (1) ES2071628T3 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
CA2289665C (en) † 1997-06-13 2005-08-09 Genentech, Inc. Protein recovery by chromatography followed by filtration upon a charged layer
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
ES2321539T3 (es) * 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
DE10155984A1 (de) * 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CA2516518A1 (en) * 2003-02-28 2004-09-10 Lonza Biologics Plc. Antibody purification by protein a and ion exchange chromatography
DK3095793T3 (da) 2003-07-28 2020-05-25 Genentech Inc Reducering af udvaskning af protein A under en protein A-affinitetskromatografi
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
CA2581208A1 (en) * 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
CA2583578C (en) 2004-10-21 2014-04-01 Ge Healthcare Bio-Sciences Ab Chromatography ligand
EP1869065B1 (en) * 2005-03-11 2020-05-06 Wyeth LLC A method of weak partitioning chromatography
CN1830495B (zh) * 2005-03-11 2010-12-15 广东天普生化医药股份有限公司 基于亲和吸附的血液净化方法及系统
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
WO2008051448A2 (en) * 2006-10-19 2008-05-02 Tolerx, Inc. Methods and compositions for efficient removal of protein a from binding molecule preparations
US7589183B2 (en) * 2006-11-28 2009-09-15 Bio-Rad Laboratories, Inc. Prevention of leaching of ligands from affinity-based purification systems
WO2009007993A2 (en) * 2007-04-23 2009-01-15 Arvind Mallinath Lali A process for purification of immunoglobulins using a pseudobioaffinity adsorbent
CN101679509A (zh) 2007-06-01 2010-03-24 弗·哈夫曼-拉罗切有限公司 免疫球蛋白纯化
SG177202A1 (en) * 2008-09-15 2012-01-30 Emd Millipore Corp Methods for quantifying protein leakage from protein based affinity chromatography resins
JP2012513425A (ja) 2008-12-22 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー 免疫グロブリンの精製
EP2519536A4 (en) 2009-12-29 2013-06-05 Reddys Lab Ltd Dr PROTEIN PURIFICATION BY ION EXCHANGE
DE102010054766B4 (de) 2010-12-16 2012-08-30 Previpharma Ag Verfahren zur Trennung, Aufkonzentration oder Reinigung eines (Blut)Plasmaproteins oder Virenbestandteils aus einer Mischung
SG11201402485UA (en) * 2011-11-21 2014-06-27 Genentech Inc Purification of anti-c-met antibodies
PL3116891T3 (pl) 2014-03-10 2020-07-27 Richter Gedeon Nyrt. Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833085A (en) * 1986-08-13 1989-05-23 Monsanto Company Monoclonal antibody specific for human colon fibroblast-derived t-PA

Also Published As

Publication number Publication date
DE68922338D1 (de) 1995-06-01
ATE121752T1 (de) 1995-05-15
EP0345549A2 (en) 1989-12-13
JPH0284193A (ja) 1990-03-26
JP2664478B2 (ja) 1997-10-15
DE68922338T2 (de) 1995-08-31
EP0345549A3 (en) 1990-09-19
EP0345549B1 (en) 1995-04-26
CA1339188C (en) 1997-07-29
US4983722A (en) 1991-01-08

Similar Documents

Publication Publication Date Title
ES2071628T3 (es) Separacion de proteina a de preparaciones de anticuerpos.
AU5525090A (en) Monoclonal antibody to amyloid peptide
AU542802B2 (en) Immunoassay for nonenzymatically glucosylated proteins and protein fragments
NZ213535A (en) Purified polyclonal antibody that binds selectively to the marker epitope encompassing amino acid position 12 of an activated form of oncogenic p21 protein
FI864427A0 (fi) Menetelmä polypeptidin valmistamiseksi, joka on komplementaarinen ainakin osalle alkuperäistä peptidiä tai proteiinia, ja komplementaarisen polypeptidin käyttö
AU564383B2 (en) Monoclonal antibody immunoassay
NO913186D0 (no) Fremgangsmaate for anvendelse og syntese av peptider.
GB9206422D0 (en) Antibody preparation
BG60256B1 (bg) Рекомбинантен метод за получаване на лимфотоксин
GB2114289B (en) Immunoassay for class specific immunoglobulin antibodies
EP0450099A4 (en) Carrier for binding antiphospholipid antibody, immunoassay using the same, and kit therefor
AU548783B2 (en) Immunoassay of proteins
AU7345487A (en) Layered immunoassay using antibodies bound to transport particles to determine the presence of an antigen
ZA833483B (en) In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
AU6036690A (en) Human monoclonal antibodies to hiv-1mn gp 120
AU2420888A (en) Immunoassay for antibodies binding platelets
GB2233091B (en) Immunoassays using monoclonal antibodies directed against natural binding proteins
HU895916D0 (en) Process for the preparation of monoclonal antibody recognaizing reg protein
AU590731B2 (en) Estriol-3-sulfate protein conjugates and antibodies thereto
AU572955B2 (en) Monoclonal antibody specific to gliadin protein of wheat
EP0205046A3 (en) Monoclonal antibody to human protein c
AU4668889A (en) Monoclonal antibodies specific for tumor antigens
IL85115A0 (en) Method for developing protein adsorbing matrix
GB8423816D0 (en) Antibody/antigen protein
AU4413589A (en) Monoclonal antibodies against cytosolic thyroid hormone binding protein

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 345549

Country of ref document: ES