BRPI0608584B8 - métodos de recuperar um produto purificado - Google Patents

métodos de recuperar um produto purificado

Info

Publication number
BRPI0608584B8
BRPI0608584B8 BRPI0608584A BRPI0608584A BRPI0608584B8 BR PI0608584 B8 BRPI0608584 B8 BR PI0608584B8 BR PI0608584 A BRPI0608584 A BR PI0608584A BR PI0608584 A BRPI0608584 A BR PI0608584A BR PI0608584 B8 BRPI0608584 B8 BR PI0608584B8
Authority
BR
Brazil
Prior art keywords
methods
recovering
product
purified product
medium
Prior art date
Application number
BRPI0608584A
Other languages
English (en)
Inventor
D Kelley Brian
Edward Booth James
Coffman Jon
Beth Switzer Mary
Brown Paul
Godavarti Ranganathan
Sun Shujun
Vunnum Suresh
Yu Tianning
Iskra Tim
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36992346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0608584(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0608584A2 publication Critical patent/BRPI0608584A2/pt
Publication of BRPI0608584B1 publication Critical patent/BRPI0608584B1/pt
Publication of BRPI0608584B8 publication Critical patent/BRPI0608584B8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

métodos de recuperar um produto e um anticorpo purificado de um fluido de carregamento. esta invenção refere-se aos métodos de uso de cromatografia de partição fraca para a purificação de um produto de um fluido de carregamento contendo uma ou mais impurezas. em adição, a invenção refere-se aos métodos de cromatografia de partição fraca definidos pelas condições de operação que fazem com que um meio ligue pelo menos 1 mg de produto por ml de meio, ou alternativamente, definidos por um coeficiente de partição de pelo menos 0,1.
BRPI0608584A 2005-03-11 2006-03-10 métodos de recuperar um produto purificado BRPI0608584B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66043705P 2005-03-11 2005-03-11
US60/660,437 2005-03-11
PCT/US2006/008919 WO2006099308A2 (en) 2005-03-11 2006-03-10 A method of weak partitioning chromatography

Publications (3)

Publication Number Publication Date
BRPI0608584A2 BRPI0608584A2 (pt) 2010-01-19
BRPI0608584B1 BRPI0608584B1 (pt) 2018-02-06
BRPI0608584B8 true BRPI0608584B8 (pt) 2021-05-25

Family

ID=36992346

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608584A BRPI0608584B8 (pt) 2005-03-11 2006-03-10 métodos de recuperar um produto purificado

Country Status (21)

Country Link
US (3) US8067182B2 (pt)
EP (1) EP1869065B1 (pt)
JP (1) JP5199063B2 (pt)
KR (2) KR101482791B1 (pt)
CN (2) CN104610422A (pt)
AU (1) AU2006223180B2 (pt)
BR (1) BRPI0608584B8 (pt)
CA (1) CA2601062C (pt)
CR (1) CR9377A (pt)
DK (1) DK1869065T3 (pt)
ES (1) ES2797480T3 (pt)
HK (1) HK1210476A1 (pt)
HU (1) HUE049797T2 (pt)
IL (1) IL185687A (pt)
MX (1) MX2007011129A (pt)
NO (1) NO20074443L (pt)
PL (1) PL1869065T3 (pt)
PT (1) PT1869065T (pt)
RU (1) RU2457214C2 (pt)
SI (1) SI1869065T1 (pt)
WO (1) WO2006099308A2 (pt)

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Also Published As

Publication number Publication date
IL185687A0 (en) 2008-01-06
US8067182B2 (en) 2011-11-29
MX2007011129A (es) 2007-11-06
EP1869065A2 (en) 2007-12-26
NO20074443L (no) 2007-09-27
PT1869065T (pt) 2020-06-18
JP5199063B2 (ja) 2013-05-15
AU2006223180B2 (en) 2011-11-24
WO2006099308A2 (en) 2006-09-21
WO2006099308A3 (en) 2007-10-25
CN101175765A (zh) 2008-05-07
US20070054390A1 (en) 2007-03-08
US20120138537A1 (en) 2012-06-07
KR20070121667A (ko) 2007-12-27
RU2007132851A (ru) 2009-04-20
BRPI0608584A2 (pt) 2010-01-19
US20070060741A1 (en) 2007-03-15
RU2457214C2 (ru) 2012-07-27
US9144755B2 (en) 2015-09-29
HK1210476A1 (en) 2016-04-22
KR20130128020A (ko) 2013-11-25
PL1869065T3 (pl) 2020-09-21
AU2006223180A1 (en) 2006-09-21
CA2601062C (en) 2016-08-02
CN104610422A (zh) 2015-05-13
BRPI0608584B1 (pt) 2018-02-06
IL185687A (en) 2015-05-31
KR101482791B1 (ko) 2015-01-21
JP2008533473A (ja) 2008-08-21
KR101660575B1 (ko) 2016-09-27
ES2797480T3 (es) 2020-12-02
CR9377A (es) 2008-02-21
DK1869065T3 (da) 2020-06-08
EP1869065A4 (en) 2012-07-04
EP1869065B1 (en) 2020-05-06
HUE049797T2 (hu) 2020-10-28
CA2601062A1 (en) 2006-09-21
SI1869065T1 (sl) 2020-08-31

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