ES2072976T3 - Poliuretanos biodegradables. - Google Patents

Poliuretanos biodegradables.

Info

Publication number
ES2072976T3
ES2072976T3 ES90302867T ES90302867T ES2072976T3 ES 2072976 T3 ES2072976 T3 ES 2072976T3 ES 90302867 T ES90302867 T ES 90302867T ES 90302867 T ES90302867 T ES 90302867T ES 2072976 T3 ES2072976 T3 ES 2072976T3
Authority
ES
Spain
Prior art keywords
aza
imino
segments
oxygen
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302867T
Other languages
English (en)
Inventor
Yoshiharu Kimura
Soonih Kim
Akio Nishiura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2072976T3 publication Critical patent/ES2072976T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/38—Low-molecular-weight compounds having heteroatoms other than oxygen
    • C08G18/3819—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen
    • C08G18/3836—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen containing azo groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

POLIURETANO (I) DE 1000 A 100000 DE PESO MOLECULAR, QUE COMPRENDE VARIOS SEGMENTOS, LOS CUALES SON UNIDADES ESTRUCTURALES DE A-B, A-C Y A-D DE LAS FORMULAS: FIG LA PROPORCION MOLAR DE DICHOS SEGMENTOS DE A-B, A-C Y A-D SON X:Y:Z, SIENDO DE 0.01 A 0.8: DE 0 A 0.80: DE 0 A 0.99. SIEMPRE QUE LA SUMA DE X, Y Y Z SEA 1.0; EN DONDE R1 ES UN ESQUELETO DE DISOCIANATO, AZA ES UN GRUPO DE LA FORMULA: FIG EN DONDE Y1 E Y2 REPRESENTAN OXIGENO, DERIVADOS DE IMINO (-NH-) E HIDROCARBONO; R4 Y R5 SON SUSTITUTIVOS OPCIONALES; R2 ES UN RESIDUO DE GLICOL POLIALQUILENO; Z ES OXIGENO O IMINO; R3 ES ALQUILENO O ELR ESIDUO DE UN ETER O AMINA SECUNDARIA O TERCIARIA. LOS POLURETANOS SON UTILES PARA RECUBRIR LOS MEDICAMENTOS QUE HAN DE LIBERARSE EN EL INTESTINO GRUESO.
ES90302867T 1989-03-17 1990-03-16 Poliuretanos biodegradables. Expired - Lifetime ES2072976T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6513689 1989-03-17

Publications (1)

Publication Number Publication Date
ES2072976T3 true ES2072976T3 (es) 1995-08-01

Family

ID=13278168

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302867T Expired - Lifetime ES2072976T3 (es) 1989-03-17 1990-03-16 Poliuretanos biodegradables.

Country Status (8)

Country Link
EP (1) EP0398472B1 (es)
JP (1) JP2855463B2 (es)
KR (1) KR0158206B1 (es)
AT (1) ATE114681T1 (es)
CA (1) CA2012469C (es)
DE (1) DE69014404T2 (es)
DK (1) DK0398472T3 (es)
ES (1) ES2072976T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194463B1 (en) * 1991-09-27 1995-06-20 Eastman Kodak Co Light-absorbing polyurethane compositions and thermoplastic polymers colored therewith
DE69229710T2 (de) * 1991-11-15 2000-03-02 Kanegafuchi Kagaku Kogyo K.K., Osaka Esterbindung enthaltende Polymere für pharmazeutische Zubereitungen
US5886091A (en) * 1996-01-05 1999-03-23 Milliken & Company Printing ink composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3909497A (en) * 1974-04-12 1975-09-30 Stanford Research Inst Solid polymers thermally degradable to flowable compositions
US4235988A (en) * 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
NZ193221A (en) * 1979-03-21 1984-08-24 M P Embrey Controlled release composition
DE3242559A1 (de) * 1982-11-18 1984-05-24 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von gegebenenfalls zelligen polyurethan-polyharnstoff-formkoerpern
US4663308A (en) * 1984-07-18 1987-05-05 Medical College Of Ohio Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract

Also Published As

Publication number Publication date
DE69014404D1 (de) 1995-01-12
JPH037718A (ja) 1991-01-14
DK0398472T3 (da) 1995-01-16
KR900014451A (ko) 1990-10-24
EP0398472A2 (en) 1990-11-22
CA2012469A1 (en) 1990-09-17
EP0398472B1 (en) 1994-11-30
KR0158206B1 (ko) 1999-02-18
JP2855463B2 (ja) 1999-02-10
DE69014404T2 (de) 1995-05-18
CA2012469C (en) 1998-05-12
EP0398472A3 (en) 1991-09-18
ATE114681T1 (de) 1994-12-15

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