ES2073530T3 - Derivados azolicos y composicion antiulcerosa que los contiene. - Google Patents

Derivados azolicos y composicion antiulcerosa que los contiene.

Info

Publication number
ES2073530T3
ES2073530T3 ES90307086T ES90307086T ES2073530T3 ES 2073530 T3 ES2073530 T3 ES 2073530T3 ES 90307086 T ES90307086 T ES 90307086T ES 90307086 T ES90307086 T ES 90307086T ES 2073530 T3 ES2073530 T3 ES 2073530T3
Authority
ES
Spain
Prior art keywords
group
unsaturated
saturated
represent
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90307086T
Other languages
English (en)
Inventor
Kiyoaki Katano
Tamako Tomomoto
Hiroko Ogino
Naoki Yamazaki
Fumiya Hirano
Yasukatsu Yuda
Fukio Konno
Motohiro Nishio
Tomoya Machinami
Seiji Shibahara
Takashi Tsuruoka
Shigeharu Inouye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2073530T3 publication Critical patent/ES2073530T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN LA FORMULA A,B, C Y D REPRESENTAN CADA UNA -CH= O -N=, CON LA CONDICION DE QUE AL MENOS UNA DE ELLAS SEA -N=; X REPRESENTA -NH-, -O- O -S-; Y REPRESENTA -(CH2)P- EN DONDE P ES UN ENTERO ENTRE 0 Y 4, -C(CH3)2, -CH2CH=CH, -CH2CO-, -CF2- O -CH2COCH2-; R1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL C1-C4, UN ATOMO DE HALOGENO O UN GRUPO ALCOXI C1-C4; R2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXIL, UN GRUPO ALQUIL C1-6 SATURADO O INSATURADO, UN GRUPO ALKOXI C1-6, UN GRUPO CARBOXIL, UN GRUPO ALKOXICARBONIL C1-12 SATURADO O INSATURADO QUE PUEDE SER OPCIONALMENTE SUBSTITUIDO, UN GRUPO CICLOALKOXICARBONIL, UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS SATURADO O INSATURADO CONTENIENDO AL MENOS UN ATOMO DE NITROGENO OPCIONALMENTE CON UNO O MAS ATOMOS DE NITROGENO Y / O ATOMOS DE OXIGENO, QUE PUEDE ESTAR OPCIONALMENTE CONDENSADO Y / O SUBSTITUIDO, -CONR3R4, -NR3R4, -OCOR3 O -NHCONHR3 DONDE R3 Y R4 PUEDEN SER LO MISMO O DIFERENTE, REPRESENTAN UN GRUPO ALQUIL C1-C6 QUE PUEDE ESTAR OPCIONALMENTE SUBSTITUIDO O UN GRUPO CICLOALQUIL, Y M Y N REPRESENTAN CADA UNA UN ENTERO ENTRE 0 Y 2.
ES90307086T 1989-06-29 1990-06-28 Derivados azolicos y composicion antiulcerosa que los contiene. Expired - Lifetime ES2073530T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16524489 1989-06-29
JP30336689 1989-11-24

Publications (1)

Publication Number Publication Date
ES2073530T3 true ES2073530T3 (es) 1995-08-16

Family

ID=26490053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90307086T Expired - Lifetime ES2073530T3 (es) 1989-06-29 1990-06-28 Derivados azolicos y composicion antiulcerosa que los contiene.

Country Status (10)

Country Link
US (2) US5079255A (es)
EP (1) EP0405976B1 (es)
JP (1) JP2679745B2 (es)
KR (1) KR930001414B1 (es)
AT (1) ATE120744T1 (es)
CA (1) CA2020006A1 (es)
DE (1) DE69018324T2 (es)
DK (1) DK0405976T3 (es)
ES (1) ES2073530T3 (es)
GR (1) GR3015703T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432554B1 (en) 1992-02-10 2002-08-13 Iap Research, Inc. Apparatus and method for making an electrical component
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6448262B1 (en) 1998-11-16 2002-09-10 American Cyanamid Company Pesticidal and parasiticidal use of 2-(substituted thio) thiazolo-[4,5-b]pyridine compounds
ATE408593T1 (de) * 2001-05-03 2008-10-15 Galileo Lab Inc Pyruvatderivate
US6914068B2 (en) * 2001-07-12 2005-07-05 Basf Aktiengesellschaft Thiazolo[4,5-b]pyridines as fungicides
ES2284945T3 (es) 2001-09-10 2007-11-16 Basf Aktiengesellschaft Compuestos pesticidas y parasiticidas de alqueno di y trifluorosustituido.
US8173688B2 (en) * 2008-06-13 2012-05-08 Nexmed Holdings, Inc. Thiazole compounds, and compositions and methods using same
ES2436625T3 (es) 2009-05-12 2014-01-03 Basf Se Proceso para producir óxido de propileno

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation
FR2190426A1 (en) * 1972-06-27 1974-02-01 Ferlux Derivs of pyrido oxazolyl thiocarboxylic acids - analgesics hypotensives and choleretics, prepd from 2-mercapto oxazolo pyridine and halo acid deriv
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
US4275065A (en) * 1979-06-21 1981-06-23 American Home Products Corporation Modulating the immune response with 2-substituted-3-hydroxythiazolo[2,3-b]be
JPS58116489A (ja) * 1981-12-28 1983-07-11 Otsuka Pharmaceut Factory Inc カルボン酸アミド誘導体
US4443606A (en) * 1982-06-16 1984-04-17 American Home Products Corporation Antiviral thiazolo [5,4-b] pyridine compounds
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
EP0178438A1 (en) * 1984-09-19 1986-04-23 Beecham Group Plc Novel compounds
EP0187977B1 (en) * 1984-12-18 1990-08-29 Otsuka Pharmaceutical Co., Ltd. Tetrahydroquinoline derivatives, process for preparing the same and anti-peptic ulcer compositions containg the same
JPS61145182A (ja) * 1984-12-18 1986-07-02 Otsuka Pharmaceut Co Ltd イミダゾピリジン誘導体
JPS61161283A (ja) * 1985-01-10 1986-07-21 Kotobuki Seiyaku Kk 新規イミダゾピリジン及びイミダゾピリミジン誘導体並びにその製法
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
JPS62207271A (ja) * 1986-03-06 1987-09-11 Yamanouchi Pharmaceut Co Ltd ２−ピリジルメチルチオ基または２−ピリジルメチルスルフイニル基で置換された縮合環化合物
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
EP0370436A3 (en) * 1988-11-22 1990-10-31 Meiji Seika Kaisha Ltd. Novel benzothiazole and benzimidazole derivatives and antiulcer agent containing the same

Also Published As

Publication number Publication date
DE69018324T2 (de) 1995-08-17
US5141946A (en) 1992-08-25
JP2679745B2 (ja) 1997-11-19
JPH03218377A (ja) 1991-09-25
ATE120744T1 (de) 1995-04-15
KR910000725A (ko) 1991-01-30
US5079255A (en) 1992-01-07
DE69018324D1 (de) 1995-05-11
EP0405976A1 (en) 1991-01-02
EP0405976B1 (en) 1995-04-05
CA2020006A1 (en) 1990-12-30
KR930001414B1 (ko) 1993-02-27
DK0405976T3 (da) 1995-06-19
GR3015703T3 (en) 1995-07-31

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