ES2073562T3 - Aparato y procedimiento para el cultivo de celulas animales. - Google Patents

Aparato y procedimiento para el cultivo de celulas animales.

Info

Publication number
ES2073562T3
ES2073562T3 ES90901239T ES90901239T ES2073562T3 ES 2073562 T3 ES2073562 T3 ES 2073562T3 ES 90901239 T ES90901239 T ES 90901239T ES 90901239 T ES90901239 T ES 90901239T ES 2073562 T3 ES2073562 T3 ES 2073562T3
Authority
ES
Spain
Prior art keywords
subunit
culture
animal cells
scale
packed bed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90901239T
Other languages
English (en)
Inventor
Rudolf F Bliem
Robert V Oakley
Van Taiariol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of ES2073562T3 publication Critical patent/ES2073562T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN APARATO PARA EL CULTIVO IN VITRO DE CELULAS ANIMALES PARA RECUBRIR PROTEINAS SEGREGADAS DE INTERES DE ELLO, PERMITIENDOSE LA CAPACIDAD DE SER RAPIDA Y PREVISIBLEMENTE AUMENTADO Y DISMINUIDO A LAS PROPORCIONES DE PRODUCCION DE PROTEINA DESEADAS; COMPRENDE UNA COLOCACION ALOJADA (20) DE SUBUNIDADES DE CULTIVO (10) QUE CONTIENEN UN LECHO EMPAQUETADO DE PARTICULAS PORTADORAS (30), CADA SUBUNIDAD ES ALIMENTADA EN PARALELO DE UNA FUENTE DE MEDIO DE CULTIVO COMUN (42,21); Y EL FLUIDO DE CULTIVO ENVIADO DESDE CADA SUBUNIDAD ES DIRIGIDO A UN CONDUCTO DE FLUIDO ENVIADO COMUN (15) DENTRO DE LA COLOCACION (20). EL AUMENTO Y DISMINUCION ES EFECTUADO POR ADICCION O SUSTRACCION DE SUBUNIDADES DE CULTIVO (10) Y/O POR INCREMENTAR O DECRECER EL VOLUMEN DE PARTICULA PORTADORA DENTRO DE UNA SUBUNIDAD (10) MIENTRAS MANTENER ALTO EL LECHO EMPAQUETADO SUSTANCIALMENTE CONSTANTE.
ES90901239T 1988-12-19 1989-11-22 Aparato y procedimiento para el cultivo de celulas animales. Expired - Lifetime ES2073562T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/286,756 US5102790A (en) 1988-12-19 1988-12-19 Method for culturing animal cells

Publications (1)

Publication Number Publication Date
ES2073562T3 true ES2073562T3 (es) 1995-08-16

Family

ID=23100034

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90901239T Expired - Lifetime ES2073562T3 (es) 1988-12-19 1989-11-22 Aparato y procedimiento para el cultivo de celulas animales.

Country Status (7)

Country Link
US (1) US5102790A (es)
EP (1) EP0402449B1 (es)
JP (1) JP2832642B2 (es)
AT (1) ATE119575T1 (es)
DE (1) DE68921615T2 (es)
ES (1) ES2073562T3 (es)
WO (1) WO1990007004A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187095A (en) * 1988-12-19 1993-02-16 Baxter International Inc. Apparatus for culturing animal cells
JPH08501251A (ja) * 1992-09-16 1996-02-13 ロトロン・インコーポレーテッド モジュールトレーを有するバイオフィルター
KR100834110B1 (ko) * 2007-01-25 2008-06-02 한국과학기술원 상류 충전탑 세포재순환 장치가 장착된 다단계 ｃｓｔｒ생물반응기 시스템
US20200377838A1 (en) * 2018-02-19 2020-12-03 National Research Council Of Canada A Microfluidic Device for Culturing Cells Comprising A Biowall, A Bead Bed and A Biointerface and Methods of Modelling Said Biointerface Thereof
US10843118B2 (en) * 2018-10-30 2020-11-24 Granitefuel Engineering Inc. Filtration apparatus with cartridge assembly
CN121773191A (zh) * 2023-09-06 2026-03-31 整合培育株式会社 细胞培养装置和细胞培养方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2338346A (en) * 1940-02-26 1944-01-04 Universal Oil Prod Co Apparatus for catalytic conversion reactions
US2338345A (en) * 1941-03-24 1944-01-04 Universal Oil Prod Co Catalytic reactor
US2317449A (en) * 1941-10-31 1943-04-27 Universal Oil Prod Co Reactor
CH615841A5 (en) * 1976-01-13 1980-02-29 Mueller Hans Dr Ing Fa Enzyme reactor
DE2624047C3 (de) * 1976-05-28 1980-07-03 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Massenzüchtung von Zellen und Kammer-System zu ihrer Durchführung
GB1539263A (en) * 1976-11-19 1979-01-31 Toray Industries Apparatus and methods for growing cells
GB1601475A (en) * 1977-04-18 1981-10-28 Ici Ltd Catalytic reactor
AU6156780A (en) * 1979-08-24 1981-04-09 G.D. Searle & Co. Stack plate culture
GB2103239B (en) * 1981-07-27 1985-09-11 Apv Company Limited The Improvements in cell tissue culture
US4377639A (en) * 1982-01-18 1983-03-22 University Of Toledo Tissue culture device for mass cell culture
US4661458A (en) * 1983-08-31 1987-04-28 Cell Environmental Systems, Ltd. Cell culture system
AU5452986A (en) * 1985-02-28 1986-09-24 Verax Corp. Fluidized bioreactor and cell cultivation process
EP0205790B1 (de) * 1985-06-18 1992-01-08 Anawa München Aktiengesellschaft Biologische Laboratorien Träger für die Kultivierung von menschlichen und/oder tierischen Zellen in einem Fermenter
JPS6211887A (ja) * 1985-07-10 1987-01-20 日本電気ソフトウェア株式会社 文字パタ−ン生成制御方式
US4722902A (en) * 1985-11-04 1988-02-02 Endotronics, Inc. Apparatus and method for culturing cells, removing waste and concentrating product
US4833083A (en) * 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor

Also Published As

Publication number Publication date
EP0402449B1 (en) 1995-03-08
EP0402449A4 (en) 1992-04-22
US5102790A (en) 1992-04-07
DE68921615D1 (de) 1995-04-13
JPH03503488A (ja) 1991-08-08
JP2832642B2 (ja) 1998-12-09
ATE119575T1 (de) 1995-03-15
EP0402449A1 (en) 1990-12-19
WO1990007004A1 (en) 1990-06-28
DE68921615T2 (de) 1995-07-20

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