ES2072892T3 - Proteina receptora para un factor 2 estimulante de celulas b humanas. - Google Patents
Proteina receptora para un factor 2 estimulante de celulas b humanas.Info
- Publication number
- ES2072892T3 ES2072892T3 ES89300536T ES89300536T ES2072892T3 ES 2072892 T3 ES2072892 T3 ES 2072892T3 ES 89300536 T ES89300536 T ES 89300536T ES 89300536 T ES89300536 T ES 89300536T ES 2072892 T3 ES2072892 T3 ES 2072892T3
- Authority
- ES
- Spain
- Prior art keywords
- receptor protein
- human
- stimulating factor
- cells
- mentioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004936 stimulating effect Effects 0.000 title abstract 3
- 102000005962 receptors Human genes 0.000 abstract 5
- 108020003175 receptors Proteins 0.000 abstract 5
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PROTEINAS RECEPTORAS DEL FACTOR 2 DE ESTIMULACION DE LAS CELULAS B HUMANAS, AISLADAS, SON CAPACES DE LIGAR DICHO FACTOR DE ESTIMULACION. EL DNA QUE CODIFICA LAS MENCIONADAS PROTEINAS, LOS VECTORES DE EXPRESION QUE LO CONTIENEN, ORGANISMOS PROTADORES TRANSFORMADOS POR EL MENCIONADO VECTOR DE EXPRESION, Y UN PROCESO DE PRODUCCION DE LA PROTEINA RECEPTORA SON DESCRITOS, ASI COMO UN ANTICUERPO QUE REACCIONA CON DICHA PROTEINA.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1238788 | 1988-01-22 | ||
| JP1259988 | 1988-01-25 | ||
| JP19488588 | 1988-08-04 | ||
| JP746189 | 1989-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2072892T3 true ES2072892T3 (es) | 1995-08-01 |
Family
ID=27454721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89300536T Expired - Lifetime ES2072892T3 (es) | 1988-01-22 | 1989-01-20 | Proteina receptora para un factor 2 estimulante de celulas b humanas. |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US5171840A (es) |
| EP (1) | EP0325474B1 (es) |
| JP (1) | JP2865300B2 (es) |
| KR (1) | KR0144861B1 (es) |
| AT (1) | ATE123295T1 (es) |
| AU (1) | AU615715B2 (es) |
| CA (1) | CA1341152C (es) |
| DE (1) | DE68922869T2 (es) |
| ES (1) | ES2072892T3 (es) |
| HK (1) | HK49997A (es) |
| IL (1) | IL89011A (es) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428979B1 (en) | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| US5670373A (en) * | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| CA1341152C (en) * | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
| US5216128A (en) * | 1989-06-01 | 1993-06-01 | Yeda Research And Development Co., Ltd. | IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it |
| ATE144713T1 (de) * | 1989-07-20 | 1996-11-15 | Tadamitsu Kishimoto | Antikörper gegen menschlichen interleukin-6- rezeptor |
| US5453491A (en) * | 1990-09-11 | 1995-09-26 | Kiyoshi Takatsu | Murine interleukin-5 receptor |
| WO1994025036A1 (fr) * | 1993-04-30 | 1994-11-10 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteur d'expression contenant un derive d'oligonucleotide antisens, agissant contre le recepteur de l'interleukine-6 humain |
| US5599536A (en) * | 1993-12-13 | 1997-02-04 | Sandoz Ltd. | Method for suppressing the acute phase response in a patient receiving IL-6 therapy |
| US5578301A (en) * | 1993-12-14 | 1996-11-26 | Sandoz Ltd. | Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy |
| US5518882A (en) * | 1993-12-21 | 1996-05-21 | Biotex Laboratories, Inc. | Immunological methods of component selection and recovery |
| US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| ATE552012T1 (de) | 1994-10-07 | 2012-04-15 | Chugai Pharmaceutical Co Ltd | Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff |
| PL182089B1 (en) | 1994-10-21 | 2001-11-30 | Chugai Pharmaceutical Co Ltd | Pharmaceutic compositions for treating diseases caused by production of il-6 |
| AU4189196A (en) * | 1994-12-16 | 1996-07-03 | Chugai Seiyaku Kabushiki Kaisha | Expression inhibitor against human interleukin-6 receptor |
| JP3458512B2 (ja) | 1995-02-23 | 2003-10-20 | 東ソー株式会社 | 骨密度の変動推定方法又は骨そしょう症の診断方法及びこれに用いる試薬キット |
| ES2312184T3 (es) | 1997-03-21 | 2009-02-16 | Chugai Seiyaku Kabushiki Kaisha | Agentes preventivos terapeuticos para el tratamiento de esclerosis multiple, que contienen anticuerpos anti-receptores de il-6 antagonistas. |
| US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| KR20100068498A (ko) | 1997-08-15 | 2010-06-23 | 츄가이 세이야꾸 가부시키가이샤 | 항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는 전신성 홍반성 낭창의 예방 및/또는 치료제 |
| PT1074268E (pt) * | 1998-03-17 | 2008-02-28 | Chugai Pharmaceutical Co Ltd | Agentes profilácticos ou terapêuticos para doenças intestinais inflamatórias contendo anticorpos antagonistas do receptor il-6 |
| WO2001016166A2 (en) | 1999-08-27 | 2001-03-08 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| EP3192528A1 (en) | 2002-02-14 | 2017-07-19 | Chugai Seiyaku Kabushiki Kaisha | Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| AR048210A1 (es) * | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
| WO2005090405A1 (ja) | 2004-03-24 | 2005-09-29 | Chugai Seiyaku Kabushiki Kaisha | インターロイキン-6受容体に対するヒト型化抗体のサブタイプ |
| AU2006300234B2 (en) | 2005-10-14 | 2013-01-10 | Chugai Seiyaku Kabushiki Kaisha | Agents for suppressing damage to transplanted islets after islet transplantation |
| US8945558B2 (en) | 2005-10-21 | 2015-02-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating myocardial infarction comprising administering an IL-6 inhibitor |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| WO2007061029A1 (ja) | 2005-11-25 | 2007-05-31 | Keio University | 前立腺癌治療剤 |
| EP3135298B1 (en) | 2006-01-27 | 2018-06-06 | Keio University | Therapeutic agents for diseases involving choroidal neovascularization |
| EP2025346B1 (en) | 2006-04-07 | 2016-08-10 | Osaka University | Muscle regeneration promoter |
| NZ587107A (en) | 2006-06-02 | 2012-05-25 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| KR101508019B1 (ko) | 2007-01-23 | 2015-04-06 | 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 | 만성 거부반응 억제제 |
| EP3246045B1 (en) | 2007-07-26 | 2025-09-03 | Osaka University | Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient |
| AU2008308163B2 (en) | 2007-10-02 | 2013-03-21 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for graft-versus-host disease comprising interleukin 6 receptor inhibitor as active ingredient |
| US8372389B2 (en) * | 2007-11-28 | 2013-02-12 | Hadasit Medical Research Services And Development Ltd. | Methods for the treatment of radiation or chemotherapy-induced tissue damage |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| CA2724279C (en) | 2008-05-13 | 2017-03-07 | Novimmune S.A. | Anti-il-6/il-6r antibodies and methods of use thereof |
| TWI528973B (zh) | 2008-06-05 | 2016-04-11 | Chugai Pharmaceutical Co Ltd | Nerve infiltration inhibitor |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US8748581B2 (en) | 2009-04-10 | 2014-06-10 | Ablynx N.V. | Anti-IL-6R polypeptides and pharmaceutical compositions thereof |
| US10618964B2 (en) | 2009-04-10 | 2020-04-14 | Ablynx N.V. | Nanobody against IL-6R |
| TW201600110A (zh) | 2009-07-31 | 2016-01-01 | Shin Maeda | 癌之轉移抑制劑 |
| CN104928336B (zh) | 2009-10-26 | 2020-05-08 | 弗·哈夫曼-拉罗切有限公司 | 用于生产糖基化免疫球蛋白的方法 |
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| SI2578231T1 (sl) | 2010-05-28 | 2023-01-31 | Chugai Seiyaku Kabushiki Kaisha | Okrepljen protitumorski T celični odzivnik |
| EP2578233B1 (en) | 2010-05-28 | 2017-04-26 | National Cancer Center | Therapeutic agent for pancreatic cancer |
| EP2787007A3 (en) | 2010-11-08 | 2015-03-11 | F. Hoffmann-La Roche AG | Subcutaneously administered ANTI-IL-6 receptor antibody |
| MX385311B (es) | 2011-01-28 | 2025-03-18 | Sanofi Biotechnology | Anticuerpos humanos frente a pcsk9 para su uso en métodos de tratamiento de grupos concretos de pacientes. |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EP2747782B1 (en) | 2011-09-23 | 2018-01-17 | Ablynx NV | Prolonged inhibition of interleukin-6 mediated signaling |
| TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| WO2013059548A1 (en) | 2011-10-19 | 2013-04-25 | Sanofi | Compositions and methods for treating cancer using jak2 inhibitor |
| JO3370B1 (ar) | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
| US9487590B2 (en) | 2012-09-25 | 2016-11-08 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| WO2014200018A1 (ja) | 2013-06-11 | 2014-12-18 | 独立行政法人 国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
| BR112015032960B1 (pt) | 2013-07-04 | 2021-01-05 | F. Hoffmann-La Roche Ag | imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro |
| EP3068803B1 (en) | 2013-11-12 | 2021-01-20 | Sanofi Biotechnology | Dosing regimens for use with pcsk9 inhibitors |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
| WO2015116852A1 (en) | 2014-01-29 | 2015-08-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating rheumatoid arthritis by administering an il-6r antibody |
| JP2017534617A (ja) | 2014-10-21 | 2017-11-24 | アブリンクス エン.ヴェー. | Il−6r関連疾患の処置 |
| TWI873632B (zh) | 2015-02-27 | 2025-02-21 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
| KR20240172758A (ko) | 2015-08-18 | 2024-12-10 | 리제너론 파아마슈티컬스, 인크. | 지단백질 분리반출술을 경험하고 있는 고지혈증을 갖는 환자를 치료하기 위한 항-pcsk9 억제성 항체 |
| US11484591B2 (en) | 2016-02-22 | 2022-11-01 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites |
| EP3596175A4 (en) | 2017-03-17 | 2021-01-13 | The Ohio State Innovation Foundation | NANOPARTICLES FOR THE ADMINISTRATION OF CHEMOPREVENTIVE AGENTS |
| US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
| US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Il-6阻害剤を含有する喘息の治療剤 |
| MA53481A (fr) | 2018-08-29 | 2021-07-07 | Regeneron Pharma | Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde |
| JP7542543B2 (ja) | 2019-01-31 | 2024-08-30 | サノフィ・バイオテクノロジー | 若年性特発性関節炎を治療するための抗il-6受容体抗体 |
| US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| WO2020213665A1 (ja) | 2019-04-17 | 2020-10-22 | 国立大学法人広島大学 | Il-6阻害剤及びccr2阻害剤を組み合わせて投与することを特徴とする泌尿器がんの治療剤 |
| CN114651010A (zh) | 2019-04-24 | 2022-06-21 | 赛诺菲生物技术公司 | 类风湿性关节炎的诊断和治疗方法 |
| KR20230061198A (ko) | 2019-06-04 | 2023-05-08 | 사노피 바이오테크놀로지 | 류마티스성 관절염을 갖는 대상체에서 통증을 치료하기 위한 조성물 및 방법 |
| JP7842101B2 (ja) | 2020-12-18 | 2026-04-07 | アブリンクス エン.ヴェー. | IL-6およびTNF-αを標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| CA3211328A1 (en) | 2021-03-12 | 2022-09-15 | Takatoshi Ozawa | Pharmaceutical composition for treatment or prevention of myasthenia gravis |
| WO2025198912A1 (en) | 2024-03-21 | 2025-09-25 | Hoffmann-La Roche Inc. | Methods of treating myasthenia gravis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6124697A (ja) * | 1984-07-11 | 1986-02-03 | Tanaka Kikai Sangyo Kk | 船舶における圧力流体の冷却方法 |
| WO1988003172A1 (en) * | 1986-10-28 | 1988-05-05 | Memorial Sloan-Kettering Cancer Center | DNA EXPRESSING Fc RECEPTOR PROTEIN |
| JPS649774A (en) * | 1987-07-02 | 1989-01-13 | Fujitsu Ltd | Thermal transfer printing method |
| JP2629712B2 (ja) * | 1987-07-03 | 1997-07-16 | 日東紡績株式会社 | インクジェット記録用紙 |
| JP2598666B2 (ja) * | 1987-10-19 | 1997-04-09 | 忠三 岸本 | 抗ヒトbcdfモノクローナル抗体 |
| CA1341152C (en) | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
-
1989
- 1989-01-19 CA CA000588703A patent/CA1341152C/en not_active Expired - Lifetime
- 1989-01-19 US US07/298,694 patent/US5171840A/en not_active Expired - Lifetime
- 1989-01-20 DE DE68922869T patent/DE68922869T2/de not_active Expired - Lifetime
- 1989-01-20 AT AT89300536T patent/ATE123295T1/de not_active IP Right Cessation
- 1989-01-20 IL IL8901189A patent/IL89011A/en unknown
- 1989-01-20 JP JP1009774A patent/JP2865300B2/ja not_active Expired - Lifetime
- 1989-01-20 ES ES89300536T patent/ES2072892T3/es not_active Expired - Lifetime
- 1989-01-20 EP EP89300536A patent/EP0325474B1/en not_active Expired - Lifetime
- 1989-01-21 KR KR1019890000644A patent/KR0144861B1/ko not_active Expired - Lifetime
- 1989-01-23 AU AU28720/89A patent/AU615715B2/en not_active Expired
-
1992
- 1992-07-02 US US07/907,650 patent/US5480796A/en not_active Expired - Lifetime
-
1995
- 1995-05-18 US US08/444,296 patent/US5851793A/en not_active Expired - Lifetime
-
1997
- 1997-04-17 HK HK49997A patent/HK49997A/en not_active IP Right Cessation
- 1997-05-27 US US08/863,196 patent/US5990282A/en not_active Expired - Fee Related
-
1999
- 1999-08-17 US US09/375,416 patent/US6410691B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL89011A0 (en) | 1989-08-15 |
| US6410691B1 (en) | 2002-06-25 |
| EP0325474A3 (en) | 1990-06-06 |
| US5851793A (en) | 1998-12-22 |
| JPH02288898A (ja) | 1990-11-28 |
| IL89011A (en) | 1995-03-15 |
| HK49997A (en) | 1997-04-25 |
| US5990282A (en) | 1999-11-23 |
| JP2865300B2 (ja) | 1999-03-08 |
| AU2872089A (en) | 1989-07-27 |
| US5480796A (en) | 1996-01-02 |
| US5171840A (en) | 1992-12-15 |
| CA1341152C (en) | 2000-12-12 |
| ATE123295T1 (de) | 1995-06-15 |
| AU615715B2 (en) | 1991-10-10 |
| EP0325474B1 (en) | 1995-05-31 |
| DE68922869D1 (de) | 1995-07-06 |
| KR890012000A (ko) | 1989-08-23 |
| DE68922869T2 (de) | 1995-10-19 |
| EP0325474A2 (en) | 1989-07-26 |
| KR0144861B1 (ko) | 1998-07-01 |
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