PT95202A - Processo para a preparacao de n-substituidas-4-pirimidinaminas e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de n-substituidas-4-pirimidinaminas e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT95202A PT95202A PT95202A PT9520290A PT95202A PT 95202 A PT95202 A PT 95202A PT 95202 A PT95202 A PT 95202A PT 9520290 A PT9520290 A PT 9520290A PT 95202 A PT95202 A PT 95202A
- Authority
- PT
- Portugal
- Prior art keywords
- loweralkyl
- hydrogen
- aryl
- pyrimidinamins
- substitutes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/402,415 US4983608A (en) | 1989-09-05 | 1989-09-05 | N-substituted-4-pyrimidinamines and pyrimidinediamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT95202A true PT95202A (pt) | 1991-05-22 |
| PT95202B PT95202B (pt) | 1997-06-30 |
Family
ID=23591798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95202A PT95202B (pt) | 1989-09-05 | 1990-09-04 | Processo para a preparacao de n-substituidas-4-pirimidinaminas e de composicoes farmaceuticas que os contem |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4983608A (pt) |
| EP (1) | EP0417584B1 (pt) |
| JP (1) | JPH07116181B2 (pt) |
| KR (1) | KR0162641B1 (pt) |
| AT (1) | ATE163012T1 (pt) |
| AU (1) | AU626450B2 (pt) |
| CA (1) | CA2024572C (pt) |
| DE (1) | DE69032020T2 (pt) |
| DK (1) | DK0417584T3 (pt) |
| ES (1) | ES2112830T3 (pt) |
| FI (1) | FI904327A7 (pt) |
| GR (1) | GR3026318T3 (pt) |
| IE (1) | IE903213A1 (pt) |
| IL (1) | IL95568A (pt) |
| NO (1) | NO903851L (pt) |
| NZ (1) | NZ235145A (pt) |
| PT (1) | PT95202B (pt) |
| ZA (1) | ZA907033B (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| WO1997009325A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
| JP2002503662A (ja) | 1998-02-17 | 2002-02-05 | テュラリク インコーポレイテッド | 抗ウイルス性ピリミジン誘導体 |
| DE69933680T2 (de) * | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
| US6632820B1 (en) | 1998-08-29 | 2003-10-14 | Astrazeneca Ab | Pyrimidine compounds |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| JP2003511378A (ja) * | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
| US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
| HUP0301117A3 (en) * | 2000-02-17 | 2004-01-28 | Amgen Inc Thousand Oaks | Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them |
| GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| US7115617B2 (en) * | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| JP2005524672A (ja) * | 2002-03-09 | 2005-08-18 | アストラゼネカ アクチボラグ | Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体 |
| GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| BR0313059B8 (pt) | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | composto, e, composição farmacêutica |
| SI1534286T1 (sl) | 2002-07-29 | 2010-04-30 | Rigel Pharmaceuticals Inc | Postopki za zdravljenje ali prepreŽŤevanje avtoimunskih bolezni z 2,4-pirimidindiaminskimi spojinami |
| EA013248B1 (ru) * | 2002-12-20 | 2010-04-30 | Пфайзер Продактс Инк. | Производные пиримидина для лечения патологического роста клеток |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| CN102358738A (zh) * | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2005111022A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidines derivatives for the treatment of abnormal cell growth |
| MXPA06011658A (es) * | 2004-05-14 | 2006-12-14 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| WO2005111016A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2006028833A1 (en) * | 2004-09-01 | 2006-03-16 | Rigel Pharmaceuticals, Inc. | Synthesis of 2,4-pyrimidinediamine compounds |
| JP5095409B2 (ja) * | 2004-11-24 | 2012-12-12 | ライジェル ファーマシューティカルズ， インコーポレイテッド | スピロ２，４−ピリミジンジアミン化合物およびその使用 |
| US20090099160A1 (en) * | 2004-12-17 | 2009-04-16 | David Andrews | 4-(4-(Imidazol-4-Yl) Pyrimidin-2-Ylamino) Benzamides as CDK Inhibitors |
| US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
| AU2006274733B2 (en) * | 2005-07-30 | 2010-09-16 | Astrazeneca Ab | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders |
| WO2007036732A1 (en) * | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| KR20100015546A (ko) | 2007-04-13 | 2010-02-12 | 사노피-아벤티스 | Ｎ-아미노인돌의 전이 금속 촉매된 합성 |
| GB2578974B (en) * | 2015-04-17 | 2020-08-19 | Univ Holy Ghost Duquesne | Cyclopenta[d]pyrimidines as antitubulin and antitumor agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
| US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
| EP0287982B1 (en) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
-
1990
- 1990-09-01 DK DK90116826T patent/DK0417584T3/da active
- 1990-09-01 AT AT90116826T patent/ATE163012T1/de not_active IP Right Cessation
- 1990-09-01 ES ES90116826T patent/ES2112830T3/es not_active Expired - Lifetime
- 1990-09-01 DE DE69032020T patent/DE69032020T2/de not_active Expired - Lifetime
- 1990-09-01 EP EP90116826A patent/EP0417584B1/en not_active Expired - Lifetime
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A7/fi not_active IP Right Cessation
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/ja not_active Expired - Lifetime
- 1990-09-04 ZA ZA907033A patent/ZA907033B/xx unknown
- 1990-09-04 PT PT95202A patent/PT95202B/pt not_active IP Right Cessation
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 NO NO90903851A patent/NO903851L/no unknown
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/ko not_active Expired - Lifetime
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
-
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2024572A1 (en) | 1991-03-06 |
| AU6208990A (en) | 1991-03-14 |
| EP0417584B1 (en) | 1998-02-04 |
| ES2112830T3 (es) | 1998-04-16 |
| DE69032020T2 (de) | 1998-07-09 |
| ATE163012T1 (de) | 1998-02-15 |
| NZ235145A (en) | 1992-12-23 |
| FI904327A0 (fi) | 1990-09-03 |
| JPH07116181B2 (ja) | 1995-12-13 |
| NO903851D0 (no) | 1990-09-04 |
| KR0162641B1 (ko) | 1998-12-01 |
| DK0417584T3 (da) | 1998-09-23 |
| GR3026318T3 (en) | 1998-06-30 |
| JPH0393784A (ja) | 1991-04-18 |
| EP0417584A2 (en) | 1991-03-20 |
| PT95202B (pt) | 1997-06-30 |
| CA2024572C (en) | 2000-09-26 |
| NO903851L (no) | 1991-03-06 |
| DE69032020D1 (de) | 1998-03-12 |
| AU626450B2 (en) | 1992-07-30 |
| IL95568A0 (en) | 1991-06-30 |
| KR910006277A (ko) | 1991-04-29 |
| US4983608A (en) | 1991-01-08 |
| ZA907033B (en) | 1991-06-26 |
| FI904327A7 (fi) | 1991-03-06 |
| IE903213A1 (en) | 1991-03-13 |
| EP0417584A3 (en) | 1992-02-26 |
| IL95568A (en) | 1995-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19901220 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19970312 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20120312 |