ES2075112T3 - Composiciones enzimaticas estabilizadas. - Google Patents

Composiciones enzimaticas estabilizadas.

Info

Publication number
ES2075112T3
ES2075112T3 ES90120781T ES90120781T ES2075112T3 ES 2075112 T3 ES2075112 T3 ES 2075112T3 ES 90120781 T ES90120781 T ES 90120781T ES 90120781 T ES90120781 T ES 90120781T ES 2075112 T3 ES2075112 T3 ES 2075112T3
Authority
ES
Spain
Prior art keywords
enzyme
reactive
enzymatic compositions
stabilized
tests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90120781T
Other languages
English (en)
Inventor
Douglas R Brandt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2075112T3 publication Critical patent/ES2075112T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA INVENCION, CONSTA DE COMPOSICIONES REACTIVAS DE ENZINAS ESTABLES NO LIOFILIZADOS, PARA A UTILIZADAR EN ENSAYOS DE DIAGNOSTICOS. UNA MATRIZ REACTIVA PARA ESTABILIZAR CREATINA QUINASA O TIENE UN SUSTRATO DE ENZIMAS POR LO MENOS Y/O UN PRODUCTO DE ENZIMAS COMBINADO CON LA ENZIMA EN MEDIO LIQUIDO POR LOS MENOS. LA MATRIZ REACTIVA PUEDE TENER TAMBIEN ACTIVADOR DE ENCIMAS ELEGIDO DE UN COMPUESTO SULFIDRILICO O UN METALICO DIVALENTE. UNA VENTAJA ADICIONAL DE LOS REACTIVADORES DE ENZIMAS ESTABILIZADOS DE LA INVENCION ES QUE PUEDEN SER APLICADOS TAMBIEN EN INSTRUMENTOS AUTOMATICOS ASI QUE PUEDEN UTILIZARSE EN ENSAYOS REALIZADOS A MANO SIN GASTO DE REACTIVOS DEBIDO A LA LIMITADA DURACION DE CONSERVACION DE LOS MISMOS.
ES90120781T 1989-10-31 1990-10-30 Composiciones enzimaticas estabilizadas. Expired - Lifetime ES2075112T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42959189A 1989-10-31 1989-10-31

Publications (1)

Publication Number Publication Date
ES2075112T3 true ES2075112T3 (es) 1995-10-01

Family

ID=23703892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90120781T Expired - Lifetime ES2075112T3 (es) 1989-10-31 1990-10-30 Composiciones enzimaticas estabilizadas.

Country Status (6)

Country Link
US (1) US5496716A (es)
EP (1) EP0426100B1 (es)
JP (1) JP2999239B2 (es)
CA (1) CA2028593C (es)
DE (1) DE69015119T2 (es)
ES (1) ES2075112T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030769A1 (en) * 1994-05-06 1995-11-16 Beckman Instruments, Inc. Liquid stable thiol activator
JP3625503B2 (ja) * 1994-11-11 2005-03-02 旭化成ファーマ株式会社 臨床検査用複合酵素含有組成物
US5817467A (en) * 1995-11-16 1998-10-06 Kyowa Medex Co., Ltd. Method for quantitatively determining creatinine kinase and a reagent therefor
JP3750955B2 (ja) * 1997-04-18 2006-03-01 富士写真フイルム株式会社 クレアチンキナーゼまたはそのｍｂアイソザイムの定量用乾式分析素子
DE19755079A1 (de) * 1997-12-11 1999-06-17 Roche Diagnostics Gmbh Stabilisiertes Reagenz und Verfahren zur Bestimmung von Creatin-Kinase
US5981249A (en) * 1998-02-05 1999-11-09 Spectral Diagnostics, Inc. Single-chain polypeptides comprising creatine kinase M and creatine kinase B
EP0989191B1 (en) * 1998-09-22 2002-11-27 Fuji Photo Film Co., Ltd. Dry analytical element for quantitative analysis of creatine kinase or its MB isozyme
US20060083793A1 (en) * 2004-09-29 2006-04-20 Gardiner Paul T Nutritional composition for promoting muscle performance and acting as hydrogen (H+) blocker
US20080118931A1 (en) * 2005-01-07 2008-05-22 Yamasa Corporation Stabilized Ornithine Transcarbamylase and Immunoassay Method for Ornithine Transcarbamylase Using the Same
SG10201810510VA (en) 2010-01-20 2018-12-28 Xyleco Inc Dispersing feedstocks and processing materials
CN103224974A (zh) * 2013-01-31 2013-07-31 浙江清华长三角研究院 一种复合转氨酶校准物质的制备方法
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
JP2023505687A (ja) 2019-12-11 2023-02-10 インスピルナ，インコーポレーテッド 癌の処置方法
CN118829726A (zh) 2022-03-08 2024-10-22 科纳斯特股份有限公司 包含胶原酶、钙、组氨酸及甘氨酸的组合物及胶原酶的稳定化方法
CN116656661A (zh) * 2023-06-01 2023-08-29 河北艾欧路生物科技有限责任公司 一种稳定而准确的复合生化校准品及其制备方法
CN120210172A (zh) * 2025-05-28 2025-06-27 江苏朗道生物技术有限公司 一种含ck-mb的生化多项液体质控品及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3556945A (en) * 1968-02-05 1971-01-19 Corning Glass Works Enzyme stabilization
US4310625A (en) * 1976-03-17 1982-01-12 Modrovich Ivan Endre Stabilized liquid enzyme compositions for diagnostic determinations
US4339533A (en) * 1980-07-30 1982-07-13 Technicon Instruments Corporation Stabilization of creatine kinase (CK) and its application as a reference standard
US4652524A (en) * 1980-10-02 1987-03-24 Ivan E. Modrovich Soluble stabilized enzymes
US4547461A (en) * 1983-01-18 1985-10-15 Eastman Kodak Company Composition, analytical element and method for the quantification of creatine kinase
JPS62104598A (ja) * 1985-11-01 1987-05-15 Yatoron:Kk クレアチンキナ−ゼ測定用試薬
DE3540076A1 (de) * 1985-11-12 1987-05-14 Boehringer Mannheim Gmbh Verfahren zur stabilisierung von creatinkinase
US4994375A (en) * 1988-07-11 1991-02-19 Baxter International Inc. Stable human serum based control and/or calibrant

Also Published As

Publication number Publication date
US5496716A (en) 1996-03-05
DE69015119T2 (de) 1995-07-27
CA2028593C (en) 2007-08-21
JP2999239B2 (ja) 2000-01-17
DE69015119D1 (de) 1995-01-26
JPH03172198A (ja) 1991-07-25
CA2028593A1 (en) 1991-05-01
EP0426100A1 (en) 1991-05-08
EP0426100B1 (en) 1994-12-14

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