ES2124893T3 - Nuevos complejos de inclusion de sales de nimesulida y de ciclodextrina. - Google Patents

Nuevos complejos de inclusion de sales de nimesulida y de ciclodextrina.

Info

Publication number
ES2124893T3
ES2124893T3 ES94919796T ES94919796T ES2124893T3 ES 2124893 T3 ES2124893 T3 ES 2124893T3 ES 94919796 T ES94919796 T ES 94919796T ES 94919796 T ES94919796 T ES 94919796T ES 2124893 T3 ES2124893 T3 ES 2124893T3
Authority
ES
Spain
Prior art keywords
inclusion
cyclodextrin
nimesulide
salts
new complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94919796T
Other languages
English (en)
Inventor
Joseph Geczy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CYCLOLAB Ltd
EUROPHARMACEUTICALS SA
Original Assignee
CYCLOLAB Ltd
EUROPHARMACEUTICALS SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CYCLOLAB Ltd, EUROPHARMACEUTICALS SA filed Critical CYCLOLAB Ltd
Application granted granted Critical
Publication of ES2124893T3 publication Critical patent/ES2124893T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPLEJOS DE INCLUSION DE SALES ALCALINOTERROSA Y ALCALI NIMESULIDO DE FORMULA GENERAL (I) DONDE ALCALINOTERROSO Y ALCALI CLODEXTRINA, COMPOSICIONES QUE LOS CONTIENEN, PROCESOS PARA LA PREPARACION DE LOS COMPLEJOS POR LA COMPLEJACION DE SALES DE NIMESULIDO POR COMPLEJACION ASI COMO METODOS PARA USARLAS COMO PRODUCTOS FARMACEUTICOS.
ES94919796T 1993-05-24 1994-05-18 Nuevos complejos de inclusion de sales de nimesulida y de ciclodextrina. Expired - Lifetime ES2124893T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9301518A HU210922B (en) 1993-05-24 1993-05-24 Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them
PCT/HU1994/000014 WO1994028031A1 (en) 1993-05-24 1994-05-18 New nimesulide salt cyclodextrin inclusion complexes

Publications (1)

Publication Number Publication Date
ES2124893T3 true ES2124893T3 (es) 1999-02-16

Family

ID=10983630

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94919796T Expired - Lifetime ES2124893T3 (es) 1993-05-24 1994-05-18 Nuevos complejos de inclusion de sales de nimesulida y de ciclodextrina.

Country Status (17)

Country Link
US (1) US5744165A (es)
EP (1) EP0656015B1 (es)
JP (1) JPH07509498A (es)
KR (1) KR950702580A (es)
AT (1) ATE170194T1 (es)
AU (1) AU675146B2 (es)
CA (1) CA2140887C (es)
CZ (1) CZ285962B6 (es)
DE (1) DE69412760T2 (es)
DK (1) DK0656015T3 (es)
ES (1) ES2124893T3 (es)
FI (1) FI950294A0 (es)
HU (1) HU210922B (es)
NO (1) NO307570B1 (es)
RU (1) RU2129564C1 (es)
SI (1) SI0656015T1 (es)
WO (1) WO1994028031A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960700361A (ko) * 1993-02-19 1996-01-20 우에하라 아키라 5-아미노아세틸아미노술폰아닐리드 화합물
HUP9601442A3 (en) * 1995-07-25 1999-03-29 Panacea Biotec Ltd Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IN186315B (es) * 1996-12-12 2001-08-04 Panacea Biotec Ltd
ES2129010B1 (es) * 1997-01-02 2000-01-16 Gold Oscar Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.
IT1291895B1 (it) 1997-04-24 1999-01-21 Errekappa Euroterapici S P A Preparazione farmaceutica fluida a base di nimesulide per uso orale e rinofaringeo
IT1298221B1 (it) * 1998-02-10 1999-12-20 Helsinn Healthcare Sa Sali micronizzati di nimesulide
PT1218889E (pt) * 1999-09-28 2010-03-08 Panacea Biotec Ltd Composições de libertação controlada compreendendo nimesulida
EP1172101A1 (en) * 2000-06-20 2002-01-16 Helsinn Healthcare S.A. The use of nimesulide for the treatment of psoriasis and psoriatic arthritis
IT1318588B1 (it) * 2000-06-20 2003-08-27 Helsinn Healthcare Sa Uso della nimesulide nel trattamento di patologie dermatologiche.
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
KR20140070676A (ko) 2002-09-06 2014-06-10 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
BR0315198A (pt) 2002-10-09 2005-08-30 Insert Therapeutics Inc Materiais e composições à base de ciclodextrina e usos relacionados aos mesmos
CN1511828A (zh) * 2002-12-31 2004-07-14 �й������ž�����ҽѧ��ѧԺ����ҽ 磺酰苯胺类衍生物及其医药用途
DE102004060914A1 (de) * 2004-12-17 2006-07-06 Bioghurt Biogarde Gmbh & Co. Kg Verwendung von Liponsäure-haltigen Cyclodextrin-Komplexen
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
RU2363473C1 (ru) * 2008-02-18 2009-08-10 Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава Способ антифлогистической активации в эксперименте
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN109608370A (zh) * 2019-01-22 2019-04-12 山西康斯亚森生物科技有限公司 尼美舒利衍生物和制备方法及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
SU1513880A1 (ru) * 1987-12-21 1991-05-07 Inst Khim Bashkirskogo Nauchno Tpиc(диизoпpoпokcи)aлюmиhиebaя coль глициppизиhoboй kиcлotы, пpoяbляющaя пpotиbobocпaлиteльhую и пpotиboязbehhую aktиbhoctь
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
IT1248475B (it) * 1990-05-22 1995-01-19 Angeli Inst Spa Composti di inclusione di nimesulide con ciclodestrine
AU7606696A (en) * 1995-11-07 1997-05-29 Seiko Communications Systems, Inc. Selective advertisement presentation

Also Published As

Publication number Publication date
WO1994028031A1 (en) 1994-12-08
DK0656015T3 (da) 1999-05-25
NO950243D0 (no) 1995-01-23
EP0656015A1 (en) 1995-06-07
NO307570B1 (no) 2000-04-25
AU7081394A (en) 1994-12-20
HU210922B (en) 1995-09-28
DE69412760T2 (de) 1999-05-20
NO950243L (no) 1995-03-13
FI950294A7 (fi) 1995-01-24
HU9301518D0 (en) 1993-09-28
EP0656015B1 (en) 1998-08-26
HUT68239A (en) 1995-06-28
ATE170194T1 (de) 1998-09-15
JPH07509498A (ja) 1995-10-19
CZ16395A3 (en) 1995-10-18
RU95105977A (ru) 1997-02-10
CZ285962B6 (cs) 1999-12-15
CA2140887A1 (en) 1994-12-08
RU2129564C1 (ru) 1999-04-27
FI950294A0 (fi) 1995-01-24
DE69412760D1 (de) 1998-10-01
CA2140887C (en) 2000-08-01
SI0656015T1 (en) 1999-02-28
AU675146B2 (en) 1997-01-23
KR950702580A (ko) 1995-07-29
US5744165A (en) 1998-04-28

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