ES2075148T3 - Acido alfa-glicosil-l-ascorbico, y su preparacion y usos. - Google Patents

Acido alfa-glicosil-l-ascorbico, y su preparacion y usos.

Info

Publication number
ES2075148T3
ES2075148T3 ES90303484T ES90303484T ES2075148T3 ES 2075148 T3 ES2075148 T3 ES 2075148T3 ES 90303484 T ES90303484 T ES 90303484T ES 90303484 T ES90303484 T ES 90303484T ES 2075148 T3 ES2075148 T3 ES 2075148T3
Authority
ES
Spain
Prior art keywords
ascorbic acid
alpha
glycosyl
preparation
saccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90303484T
Other languages
English (en)
Inventor
Itaru Yamamoto
Norio Muto
Toshio Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1274518A external-priority patent/JP2926412B2/ja
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Application granted granted Critical
Publication of ES2075148T3 publication Critical patent/ES2075148T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/82—Acid flavourants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/16—Preparation of compounds containing saccharide radicals produced by the action of an alpha-1, 6-glucosidase, e.g. amylose, debranched amylopectin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Saccharide Compounds (AREA)

Abstract

EL ACIDO ASCORBICO ALFA-GLICOSIL-L SE FORMA EN UNA SOLUCION CONTENIENDO ACIDO ASCORBICO L Y UN SACARIDO ALFA-GLUCOSIL, CUANDO ESTA SUJETO A LA ACCION DE UNA ENZIMA TRANSFERENTE DE LOS SACARIDOS. EL ACIDO ASCORBICO ALFA -GLICOSIL-L ES ESTABLE Y FACILMENTE HIDROLIZABLE IN VIVO. ASI, EL ACIDO ASCORBICO ALFA- GLICOSIL-L ES EMPLEADO EN LA INDUSTRIA FARMACEUTICA Y COSMETICA COMO ESTABILIZADOR, COMO AGENTE MEJORADOR DE LA CALIDAD, COMO ANTIOXIDANTE, COMO AGENTE FISIOLOGICAMENTE ACTIVO Y ABSORBEDOR DE RAYOS ULTRAVIOLETA.
ES90303484T 1989-05-19 1990-03-30 Acido alfa-glicosil-l-ascorbico, y su preparacion y usos. Expired - Lifetime ES2075148T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12707289 1989-05-19
JP1274518A JP2926412B2 (ja) 1989-05-19 1989-10-20 α―グリコシル―Ｌ―アスコルビン酸とその製造方法並びに用途

Publications (1)

Publication Number Publication Date
ES2075148T3 true ES2075148T3 (es) 1995-10-01

Family

ID=26463107

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90303484T Expired - Lifetime ES2075148T3 (es) 1989-05-19 1990-03-30 Acido alfa-glicosil-l-ascorbico, y su preparacion y usos.

Country Status (7)

Country Link
US (3) US5137723A (es)
EP (1) EP0398484B1 (es)
AT (1) ATE123306T1 (es)
DE (1) DE69019779T2 (es)
DK (1) DK0398484T3 (es)
ES (1) ES2075148T3 (es)
HK (1) HK111196A (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE123306T1 (de) * 1989-05-19 1995-06-15 Hayashibara Biochem Lab Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen.
JP2832848B2 (ja) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
JP2926432B2 (ja) * 1990-06-11 1999-07-28 株式会社林原生物化学研究所 養毛剤
TW197375B (es) * 1990-11-19 1993-01-01 Hayashibara Biochem Lab
US5215767A (en) * 1991-03-16 1993-06-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Additive for aquaculture feed for fish and shellfish and aquaculture feed for fish and shellfish which contains same
US5272136A (en) * 1991-10-12 1993-12-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo 5-0-α-D-Glucopyranosyl-L-ascorbic acid, and its preparation and uses
JP3072535B2 (ja) * 1991-10-21 2000-07-31 株式会社林原生物化学研究所 ５−Ｏ−α−Ｄ−グルコピラノシル−Ｌ−アスコルビン酸とその製造方法並びに用途
JP3134235B2 (ja) * 1991-10-23 2001-02-13 株式会社林原生物化学研究所 ２−Ｏ−α−Ｄ−グルコピラノシル−Ｌ−アスコルビン酸高含有物の製造方法
US5314678A (en) * 1992-01-28 1994-05-24 Mallinckrodt Medical, Inc. Sodium iodide 131 I capsules
JP3134236B2 (ja) * 1992-01-30 2001-02-13 株式会社林原生物化学研究所 α−グリコシル−Ｌ−アスコルビン酸高含有物の製造方法とその製造のための分離システム
NZ247157A (en) * 1992-03-17 1994-04-27 Ueno Seiyaku Oyo Kenkyujo Kk Production of powdery or granular crystalline maltitol from a highly concentrated aqueous solution using seed crystals
DE69428322T2 (de) * 1993-10-26 2002-06-20 Shiseido Co. Ltd., Tokio/Tokyo Hautbleichende Mittel enthaltend Glykoside
US5455035A (en) * 1994-01-13 1995-10-03 Elizabeth Arden Company, Division Of Conopco, Inc. Clear two-phase cosmetic composition
US5935584A (en) * 1994-01-13 1999-08-10 Elizabeth Arden Company Vitamin C delivery system
GB9403855D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US5573398A (en) * 1994-06-10 1996-11-12 Towle; Lawrence E. Dental hygiene device and cleaning solution
US6224376B1 (en) 1994-06-10 2001-05-01 Richard A. Cloonan Dental cleaning liquid and gel
US5837222A (en) * 1994-06-10 1998-11-17 Cloonan; Richard A. Liquid dental cleaning solution
FR2733148B1 (fr) * 1995-04-20 1997-05-30 Oreal Composition pour lutter contre les taches et/ou le vieillissement de la peau, ses utilisations
US5853741A (en) * 1996-06-28 1998-12-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Vitamin C delivery system
RU2146921C1 (ru) * 1997-11-05 2000-03-27 Рязанский областной клинический кожно-венерологический диспансер Мазевая композиция, стимулирующая регенерацию эпителия
JP4981198B2 (ja) 1998-03-31 2012-07-18 格 山本 グリコシル−ｌ−アスコルビン酸のアシル化誘導体
AU2001253137A1 (en) 2000-04-04 2001-10-15 Amarillo Biosciences, Inc. Composition and method for promoting oral health
FR2807322B1 (fr) 2000-04-10 2004-02-20 Oreal Composition, notamment cosmetique, comprenant de l'acide ascorbique en association avec un derive d'acide ascorbique
FR2807320B1 (fr) * 2000-04-10 2002-05-24 Oreal Utilisation de derives d'acide ascorbique pour augmenter la synthese des creramides epidermiques
JP2002326924A (ja) * 2001-05-07 2002-11-15 Hayashibara Biochem Lab Inc 洗顔料
KR100440190B1 (ko) * 2001-08-23 2004-07-12 박관화 아카비오신-글루코실 아스코르베이트 및 그의 제조방법
KR100440191B1 (ko) * 2001-08-23 2004-07-12 박관화 항산화 효과 및 높은 안정성을 갖는 아스코르브산 유도체및 그것의 제조방법
FR2834641B1 (fr) * 2002-01-14 2005-04-22 Ct Regional De Lutte Contre Le Protection de la neurotoxicite de l'oxaliplatine par administration de calcium et de magnesium
KR20030080869A (ko) * 2002-04-11 2003-10-17 주식회사 코리아나화장품 아스코르브산 2-글루코시드를 포함하는 피부 미백용화장료 조성물
JP4043312B2 (ja) 2002-08-06 2008-02-06 株式会社林原生物化学研究所 ２−Ｏ−α−Ｄ−グルコピラノシル−Ｌ−アスコルビン酸の製造方法
KR20040038438A (ko) * 2002-11-01 2004-05-08 주식회사 코리아나화장품 아스코르브산 2-글루코시드 및 송이 추출물을 포함하는피부 미백용 화장료 조성물
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
KR100511419B1 (ko) * 2003-09-15 2005-08-30 한국생명공학연구원 베타-프럭토실-엘-아스코르브산 및 그의 제조방법
WO2006079212A1 (en) * 2005-01-26 2006-08-03 Diamedica Inc. Use of s-adenosylmethionme, vitamin e, and vitamin c for the treatment of oxidative liver injury or insulin resistance
JP4766653B2 (ja) * 2005-01-28 2011-09-07 株式会社林原生物化学研究所 眼科用医薬組成物
WO2006090939A1 (en) * 2005-02-23 2006-08-31 Bioland Ltd. Cosmetic composition comprising beta-fructosyl-l-ascorbic acid for skin whitening
EA015357B1 (ru) * 2005-03-23 2011-06-30 Мэри Кэй Инк. Осветляющая кожу композиция
WO2006137129A1 (ja) * 2005-06-21 2006-12-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo 皮膚外用剤
KR100691540B1 (ko) * 2006-06-22 2007-03-12 주식회사 펩트론 펩타이드가 결합된 안정화된 비타민 ｃ 유도체, 이의제조방법 및 이를 함유하는 조성물
US20080254188A1 (en) * 2007-02-01 2008-10-16 National Research Council Of Canada Formulations of lipophilic bioactive molecules
US20080293637A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
CN101541776B (zh) * 2007-09-14 2011-08-03 南京华狮化工有限公司 一种抗坏血酸衍生物、其制备方法和所涉及的中间产物以及该衍生物在化妆品中的应用
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
JP5670196B2 (ja) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク． 紫斑を治療する組成物および方法
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
JP4885245B2 (ja) * 2009-01-15 2012-02-29 日本航空電子工業株式会社 Ｒｄコンバータ及び角度検出装置
SG180307A1 (en) * 2009-09-03 2012-06-28 Hayashibara Biochem Lab Powder containing anhydrous crystals of 2-o-a-d-glucosyl-l-ascorbic acid, manufacturing method therefor, and use thereof
CN102480950B (zh) * 2009-09-14 2014-07-23 国立大学法人北海道大学 抗植物病毒剂
US8927043B2 (en) * 2009-11-10 2015-01-06 Mycell Technologies Stabilized formulations of fatty acids
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171310A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
KR101764451B1 (ko) 2010-03-12 2017-08-02 알러간 인더스트리 에스에이에스 피부 상태 개선을 위한 히알루론안 폴리머 및 만니톨을 포함하는 유체 조성물
EP3078388B1 (en) 2010-03-22 2019-02-20 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
BR112013022939B1 (pt) 2011-03-07 2022-01-11 Hayashibara Co., Ltd Processo para produzir uma composição particulada
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
KR102238406B1 (ko) 2011-06-03 2021-04-08 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
EP3590495A1 (en) 2011-08-25 2020-01-08 Allergan, Inc. Dermal filler compositions including antioxidants
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
CA2896646A1 (en) 2012-12-27 2014-07-03 Hayashibara Co., Ltd. Skin-exterior anti-ageing composition and production method therefor
CN103755756B (zh) * 2014-02-11 2015-07-08 江苏诚信药业有限公司 一种制备维生素c葡萄糖苷的工艺系统及其工艺方法
EP3200838B1 (en) 2014-09-30 2019-09-18 Allergan Industrie, SAS Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
HUE047971T2 (hu) 2015-02-13 2020-05-28 Allergan Ind Sas Az arcelemek - például az áll - formázására, megnagyobbítására vagy korrekciójára szolgáló implantátumok
CA3099732A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP3928626A4 (en) 2019-02-20 2022-12-07 Hayashibara Co., Ltd. POTASSIUM SALT CRYSTAL OF 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID AND PROCESS FOR ITS PRODUCTION
EP4129282A4 (en) 2020-03-31 2024-05-01 Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd. PHARMACEUTICAL ASSOCIATION AND ITS USE
EP4129283A4 (en) 2020-03-31 2024-04-24 Natural Medicine Institute of Zhejiang Yangshengtang Co., Ltd. Pharmaceutical combination and use thereof
WO2021213455A1 (zh) 2020-04-23 2021-10-28 浙江养生堂天然药物研究所有限公司 药物组合及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD33788A (es) *
JPS4838158B1 (es) * 1970-10-05 1973-11-15
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
DD141832A1 (de) * 1978-10-31 1980-05-21 Joachim Schmidt Verfahren und vorrichtung zur herstellung von l-ascorbinsaeure
JPS59501264A (ja) * 1982-06-30 1984-07-19 マサチユ−セツツ　ゼネラル　ホスピタル ビタミンｄグリコシド類
JPS60130582A (ja) * 1983-12-19 1985-07-12 Takeda Chem Ind Ltd 食品用酸化防止剤，アスコルビン酸誘導体およびその製造法
US4822816A (en) * 1987-04-10 1989-04-18 Oxycal Laboratories, Inc. Compositions and methods for administering vitamin C
ATE123306T1 (de) * 1989-05-19 1995-06-15 Hayashibara Biochem Lab Alpha-glycosyl-l-ascorbinsäure und ihre herstellung und verwendungen.
JP2832848B2 (ja) * 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途

Also Published As

Publication number Publication date
EP0398484A2 (en) 1990-11-22
EP0398484A3 (en) 1991-02-27
US5767149A (en) 1998-06-16
DE69019779D1 (de) 1995-07-06
ATE123306T1 (de) 1995-06-15
EP0398484B1 (en) 1995-05-31
DK0398484T3 (da) 1995-07-24
DE69019779T2 (de) 1995-12-14
US5137723A (en) 1992-08-11
US5616611A (en) 1997-04-01
HK111196A (en) 1996-07-05

Similar Documents

Publication Publication Date Title
ES2075148T3 (es) Acido alfa-glicosil-l-ascorbico, y su preparacion y usos.
SE8602805L (sv) Polysackaridkompositioner, deras framstellning och anvendning
FR2634376B1 (fr) Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
AU607690B2 (en) Use of synthetic sulfated saccharides to enhance wound healing
HUT61031A (en) Process for producing chemically modified, stable haemoglobin substituting for non-immunogehic red blood cell, and pharmaceutical compositions comprising same as active ingredient
NL300084I1 (nl) Nieuwe thiofeencarbonzuur-esters van aminoalkoholen, hun kwaternairiseringsprodukten, alsmede de bereiding en toepassing van deze verbindingen.
AU8281387A (en) Cosmetic composition
IL87488A0 (en) Pharmaceutical compositions for the topical treatment of conditions associated with photodamaged skin,comprising substituted propenyl phenyl derivatives
KR900018130A (ko) α-글리코실-L-아스코르브산, 그 제조방법 및 용도
ATE50926T1 (de) Auf phosphorsaeureester basierende, oberflaechenaktive zusammensetzungen, deren herstellungsverfahren und deren verwendung um wirksame praeparate herzustellen.
HUT44489A (en) Process for production of derivatives of benzosulphonamid-indanyl and medical preparatives containing them as active substance
GR3030124T3 (en) Derivatives of cyclohexane, preparations containing them and their use
KR970009581B1 (en) Composition for topical use containing depolymerized deoxyribonucleic acids in the skin and body cosmetic treathent
DE3574109D1 (en) Vaccine against diseases due to micro-organisms such as mycoplasms, preparation thereof and membranes of micro-organisms as active principle
IL80702A0 (en) Human manganese superoxide dismutase cdna and its expression in bacteria,and method of recovering enzymatically active human manganese superoxide dismutase
EP0246569A3 (en) Superoxide dismutase derivatives, method of producing same and pharmaceutical composition
EP0310126A3 (en) Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines
ATE102019T1 (de) Mittel zur kosmetischen oder pharmazeutischen verwendung.
GB2234973B (en) Aqueous liquid enzyme formulation of proteolytically active enzymes
NZ223280A (en) High level expression in e. coli of soluble mature interleukin-1#b# and derivatives with altered biological activity
DE69010518D1 (de) Wässerige Desmopressin-CMC enthaltende Arzneizubereitung.
HUT41235A (en) Pesticide, particularly insecticide compositions and process for preparing benzoyl-carbamides to be applied as active ingredients thereof
HUT47558A (en) Process for production of 12-halogene-forscoline derivatives and medical compositions containing them as active substance
FR2567402B1 (fr) Nouvelles compositions pharmaceutiques et cosmetiques contenant comme ingredient actif la dihydroxy-1,8 phenyl-10 anthrone-9, et procede de preparation de l'ingredient actif
EP0352894A3 (en) Production of cosmetic or pharmaceutical composition

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 398484

Country of ref document: ES