ES2076592T3 - Microparticulas con efecto prolongado, biodegradables, y un procedimiento para la preparacion. - Google Patents

Microparticulas con efecto prolongado, biodegradables, y un procedimiento para la preparacion.

Info

Publication number
ES2076592T3
ES2076592T3 ES92104995T ES92104995T ES2076592T3 ES 2076592 T3 ES2076592 T3 ES 2076592T3 ES 92104995 T ES92104995 T ES 92104995T ES 92104995 T ES92104995 T ES 92104995T ES 2076592 T3 ES2076592 T3 ES 2076592T3
Authority
ES
Spain
Prior art keywords
procedure
biodegradable
microparticles
preparation
averiant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92104995T
Other languages
English (en)
Inventor
Norbert Dr Lill
Jurgen Dr Sandow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2076592T3 publication Critical patent/ES2076592T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

MICROPARTICULAS BIODEGRADABLES DE LARGA ACCION Y UN PROCEDIMIENTO PARA SU PRODUCCION SE DESCRIBEN MICROPARTICULAS BIODEGRADABLES DE LARGA DURACION QUE CONTIENEN PEPTIDOS DE ACCION TERAPEUTICA COMO SUSTANCIA ACTIVA Y POLI (LACTID RTE, QUE SE OBTIENEN MEDIANTE EL SECADO POR PULVERIZACION A TEMPERATURAS INFERIORES A 60 (GRADOS) C EN UN FLUJO PULVERIZADO MAS DE 500 NL/H.
ES92104995T 1991-03-25 1992-03-23 Microparticulas con efecto prolongado, biodegradables, y un procedimiento para la preparacion. Expired - Lifetime ES2076592T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4109746 1991-03-25

Publications (1)

Publication Number Publication Date
ES2076592T3 true ES2076592T3 (es) 1995-11-01

Family

ID=6428150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92104995T Expired - Lifetime ES2076592T3 (es) 1991-03-25 1992-03-23 Microparticulas con efecto prolongado, biodegradables, y un procedimiento para la preparacion.

Country Status (20)

Country Link
EP (1) EP0505966B1 (es)
JP (1) JP3346789B2 (es)
KR (1) KR100203253B1 (es)
AT (1) ATE124254T1 (es)
AU (1) AU653210B2 (es)
CA (1) CA2063883C (es)
CY (1) CY2032A (es)
CZ (1) CZ284756B6 (es)
DE (1) DE59202649D1 (es)
DK (1) DK0505966T3 (es)
ES (1) ES2076592T3 (es)
FI (1) FI99084C (es)
HR (1) HRP940838B1 (es)
IE (1) IE67555B1 (es)
IL (1) IL101346A0 (es)
MY (1) MY109719A (es)
NO (1) NO302856B1 (es)
NZ (1) NZ242073A (es)
YU (1) YU48420B (es)
ZA (1) ZA922130B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535937B2 (en) * 1991-10-01 2008-05-21 Takeda Chemical Industries, Ltd. Prolonged release microparticle preparation and production of the same
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
EP0625069B1 (de) * 1992-10-26 1998-12-30 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
KR100321854B1 (ko) * 1998-12-30 2002-08-28 동국제약 주식회사 루테이나이징 호르몬 릴리싱 호르몬 동족체를 함유하는 장기 서방출성 미립구 및 그의 제조방법
EP1389468A4 (en) 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS FOR PROMOTING BONE FRACTURE HEALING
CN1537018A (zh) 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
KR101041767B1 (ko) * 2002-06-25 2011-06-17 다케다 야쿠힌 고교 가부시키가이샤 서방성 조성물의 제조 방법
EP1734938B1 (en) 2004-03-26 2012-06-20 Universita' Degli Studi Di Parma Insulin highly respirable microparticles
KR100722607B1 (ko) * 2006-05-11 2007-05-28 주식회사 펩트론 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
FR2934856B1 (fr) * 2008-08-05 2010-08-13 Servier Lab Nouveau procede d'obtention de la forme cristalline v de l'agomelatine
BR102012011209A2 (pt) * 2012-05-11 2014-03-25 Bioactive Biomateriais Ltda Material tridimensional polimérico biodegradável e processo de preparo de material tridimensional polimérico biodegradável
CN105963257B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
CN105963258B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
CN109985585A (zh) * 2019-05-13 2019-07-09 苏州岸谷纳米技术有限公司 一种生物降解高分子微球的快速制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
NZ221411A (en) * 1986-08-11 1989-10-27 Innovata Biomed Ltd Pharmaceutical compositions containing microcapsules and a surfactant
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier

Also Published As

Publication number Publication date
KR100203253B1 (ko) 1999-06-15
FI921248L (fi) 1992-09-26
IE67555B1 (en) 1996-04-17
JPH0570363A (ja) 1993-03-23
AU1310992A (en) 1992-10-01
CZ284756B6 (cs) 1999-02-17
JP3346789B2 (ja) 2002-11-18
CA2063883C (en) 2001-12-11
NZ242073A (en) 1993-08-26
MY109719A (en) 1997-05-31
EP0505966A1 (de) 1992-09-30
NO921147L (no) 1992-09-28
EP0505966B1 (de) 1995-06-28
CY2032A (en) 1998-02-20
HRP940838A2 (en) 1997-06-30
IL101346A0 (en) 1992-11-15
NO921147D0 (no) 1992-03-24
HRP940838B1 (en) 2000-12-31
DE59202649D1 (de) 1995-08-03
ATE124254T1 (de) 1995-07-15
CA2063883A1 (en) 1992-09-26
YU48420B (sh) 1998-07-10
FI921248A0 (fi) 1992-03-23
NO302856B1 (no) 1998-05-04
DK0505966T3 (da) 1995-10-30
CS88792A3 (en) 1992-10-14
FI99084B (fi) 1997-06-30
YU26392A (sh) 1994-12-28
FI99084C (fi) 1997-10-10
IE920956A1 (en) 1992-10-07
ZA922130B (en) 1992-11-25
KR920017645A (ko) 1992-10-21
AU653210B2 (en) 1994-09-22

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