ES2076894B1 - Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2076894B1
ES2076894B1 ES09400191A ES9400191A ES2076894B1 ES 2076894 B1 ES2076894 B1 ES 2076894B1 ES 09400191 A ES09400191 A ES 09400191A ES 9400191 A ES9400191 A ES 9400191A ES 2076894 B1 ES2076894 B1 ES 2076894B1
Authority
ES
Spain
Prior art keywords
azolylbutyl
piperacinyl
hydroxypyrimidine
derivatives
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09400191A
Other languages
English (en)
Other versions
ES2076894A1 (es
Inventor
Constansa Jordi Frigola
Vidal Ramon Merce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2076894A1 publication Critical patent/ES2076894A1/es
Application granted granted Critical
Publication of ES2076894B1 publication Critical patent/ES2076894B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, CARACTERIZADOS POR EL HECHO DE QUE RESPONDEN A LA FORMULA GENERAL I, EN LA QUE X2 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R2, X4 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R4, X5 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R5, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTO, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDAN. PRESENTAN UNA ACTIVIDAD BIOLOGICA SOBRE EL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR ANSIOLITICA Y TRANQUILIZANTE.
ES09400191A 1993-02-05 1994-02-03 Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. Expired - Fee Related ES2076894B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301293A FR2701260B1 (fr) 1993-02-05 1993-02-05 Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.

Publications (2)

Publication Number Publication Date
ES2076894A1 ES2076894A1 (es) 1995-11-01
ES2076894B1 true ES2076894B1 (es) 1996-10-16

Family

ID=9443776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400191A Expired - Fee Related ES2076894B1 (es) 1993-02-05 1994-02-03 Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.

Country Status (15)

Country Link
US (1) US5444059A (es)
EP (1) EP0610140B1 (es)
JP (1) JPH06234762A (es)
KR (1) KR940019705A (es)
AT (1) ATE188693T1 (es)
AU (1) AU684479B2 (es)
BR (1) BR1100847A (es)
CA (1) CA2115016A1 (es)
DE (1) DE69422532D1 (es)
ES (1) ES2076894B1 (es)
FR (1) FR2701260B1 (es)
HU (1) HU218211B (es)
NO (1) NO305082B1 (es)
RU (1) RU2118318C1 (es)
ZA (1) ZA94775B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
AU780817B2 (en) * 2000-01-19 2005-04-21 Akzo Nobel N.V. Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
KR100465649B1 (ko) * 2002-09-17 2005-01-13 한국포리올 주식회사 일체형 연마 패드 및 그 제조 방법
US7456180B2 (en) * 2003-07-30 2008-11-25 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2011030139A1 (en) 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US5187276A (en) * 1983-06-18 1993-02-16 Troponwerke Gmbh & Co. Kg. 2-pyrimidinyl-1-piperazine derivatives
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
CA2024428A1 (en) * 1989-09-06 1991-03-07 Masayuki Ishikawa Agent for treating urinary obstruction
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
EP0482696B1 (en) * 1990-10-23 1996-01-10 Akzo Nobel N.V. 4-[4- or 6-(Trifluoromethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituted lactams
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Also Published As

Publication number Publication date
EP0610140A1 (fr) 1994-08-10
JPH06234762A (ja) 1994-08-23
NO940274D0 (no) 1994-01-26
ATE188693T1 (de) 2000-01-15
BR1100847A (pt) 1999-12-07
ES2076894A1 (es) 1995-11-01
FR2701260B1 (fr) 1995-05-05
HU218211B (hu) 2000-06-28
NO305082B1 (no) 1999-03-29
AU5488994A (en) 1994-08-11
RU2118318C1 (ru) 1998-08-27
EP0610140B1 (fr) 2000-01-12
DE69422532D1 (de) 2000-02-17
CA2115016A1 (fr) 1994-08-06
HU9400321D0 (en) 1994-05-30
KR940019705A (ko) 1994-09-14
HUT70196A (en) 1995-09-28
AU684479B2 (en) 1997-12-18
NO940274L (no) 1994-08-08
ZA94775B (en) 1994-09-29
FR2701260A1 (fr) 1994-08-12
US5444059A (en) 1995-08-22

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