ES2076894A1 - Derivados de 2-(4-(4-azolibutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de 2-(4-(4-azolibutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2076894A1
ES2076894A1 ES09400191A ES9400191A ES2076894A1 ES 2076894 A1 ES2076894 A1 ES 2076894A1 ES 09400191 A ES09400191 A ES 09400191A ES 9400191 A ES9400191 A ES 9400191A ES 2076894 A1 ES2076894 A1 ES 2076894A1
Authority
ES
Spain
Prior art keywords
azolylbutyl
piperazinyl
preparation
derivatives
hydroxypyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400191A
Other languages
English (en)
Other versions
ES2076894B1 (es
Inventor
Constansa Jordi Frigola
Vidal Ramon Merce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2076894A1 publication Critical patent/ES2076894A1/es
Application granted granted Critical
Publication of ES2076894B1 publication Critical patent/ES2076894B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, CARACTERIZADOS POR EL HECHO DE QUE RESPONDEN A LA FORMULA GENERAL I, EN LA QUE X2 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R2, X4 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R4, X5 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R5, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTO, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDAN. PRESENTAN UNA ACTIVIDAD BIOLOGICA SOBRE EL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR ANSIOLITICA Y TRANQUILIZANTE.
ES09400191A 1993-02-05 1994-02-03 Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. Expired - Fee Related ES2076894B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301293A FR2701260B1 (fr) 1993-02-05 1993-02-05 Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.

Publications (2)

Publication Number Publication Date
ES2076894A1 true ES2076894A1 (es) 1995-11-01
ES2076894B1 ES2076894B1 (es) 1996-10-16

Family

ID=9443776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400191A Expired - Fee Related ES2076894B1 (es) 1993-02-05 1994-02-03 Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.

Country Status (15)

Country Link
US (1) US5444059A (es)
EP (1) EP0610140B1 (es)
JP (1) JPH06234762A (es)
KR (1) KR940019705A (es)
AT (1) ATE188693T1 (es)
AU (1) AU684479B2 (es)
BR (1) BR1100847A (es)
CA (1) CA2115016A1 (es)
DE (1) DE69422532D1 (es)
ES (1) ES2076894B1 (es)
FR (1) FR2701260B1 (es)
HU (1) HU218211B (es)
NO (1) NO305082B1 (es)
RU (1) RU2118318C1 (es)
ZA (1) ZA94775B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
HUP0204050A3 (en) * 2000-01-19 2004-09-28 Akzo Nobel Nv Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
KR100465649B1 (ko) * 2002-09-17 2005-01-13 한국포리올 주식회사 일체형 연마 패드 및 그 제조 방법
RU2006105717A (ru) * 2003-07-30 2007-09-20 Зинон Фармасьютиклз Инк. (Ca) Производные пиперазина и их применение в качестве терапевтических агентов
WO2011030139A1 (en) 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129128A2 (de) * 1983-06-18 1984-12-27 Troponwerke GmbH & Co. KG 2-Pyrimidinyl-l-piperazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
EP0497658A1 (fr) * 1991-01-25 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Utilisation de dérivés 1-H-azole-(omega-(4-(2-pyrimidinyl)-1-pipérazinyl)-alkyl) pour la préparation de médicaments destinés au traitement des troubles des fonctions cognitives
EP0502786A1 (fr) * 1991-03-07 1992-09-09 Laboratorios Del Dr. Esteve, S.A. Procédé de préparation de dérivés d'aryl (ou hétéroaryl)-pipérazinyl-butyl-azoles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
US5187276A (en) * 1983-06-18 1993-02-16 Troponwerke Gmbh & Co. Kg. 2-pyrimidinyl-1-piperazine derivatives
JPH078795B2 (ja) * 1989-09-06 1995-02-01 日立化成工業株式会社 排尿障害治療剤
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
EP0482696B1 (en) * 1990-10-23 1996-01-10 Akzo Nobel N.V. 4-[4- or 6-(Trifluoromethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituted lactams
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129128A2 (de) * 1983-06-18 1984-12-27 Troponwerke GmbH & Co. KG 2-Pyrimidinyl-l-piperazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0382637A1 (fr) * 1989-02-09 1990-08-16 Laboratorios Del Dr. Esteve, S.A. Dérivés de pyrimidinyl-piperazinyl-alkyl azolès avec activité anxiolytique et/ou tranquillisante
EP0497658A1 (fr) * 1991-01-25 1992-08-05 Laboratorios Del Dr. Esteve, S.A. Utilisation de dérivés 1-H-azole-(omega-(4-(2-pyrimidinyl)-1-pipérazinyl)-alkyl) pour la préparation de médicaments destinés au traitement des troubles des fonctions cognitives
EP0502786A1 (fr) * 1991-03-07 1992-09-09 Laboratorios Del Dr. Esteve, S.A. Procédé de préparation de dérivés d'aryl (ou hétéroaryl)-pipérazinyl-butyl-azoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NISHIOKA, K. y KANAMARU, H. 14C-labeling of a novel anxiolytic agent Tandospirone. Journal of labelled compounds and Radiopharmaceuticals. 1992. Vol. XXXI, N‘ 6, pßginas 427-436 * Todo el documento * *

Also Published As

Publication number Publication date
JPH06234762A (ja) 1994-08-23
AU684479B2 (en) 1997-12-18
KR940019705A (ko) 1994-09-14
US5444059A (en) 1995-08-22
BR1100847A (pt) 1999-12-07
NO940274L (no) 1994-08-08
EP0610140A1 (fr) 1994-08-10
NO940274D0 (no) 1994-01-26
HUT70196A (en) 1995-09-28
ATE188693T1 (de) 2000-01-15
FR2701260A1 (fr) 1994-08-12
ES2076894B1 (es) 1996-10-16
NO305082B1 (no) 1999-03-29
DE69422532D1 (de) 2000-02-17
RU2118318C1 (ru) 1998-08-27
EP0610140B1 (fr) 2000-01-12
FR2701260B1 (fr) 1995-05-05
HU218211B (hu) 2000-06-28
HU9400321D0 (en) 1994-05-30
CA2115016A1 (fr) 1994-08-06
AU5488994A (en) 1994-08-11
ZA94775B (en) 1994-09-29

Similar Documents

Publication Publication Date Title
RU93043528A (ru) Моногидрат 5-(2-(4-(1,2-бензотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-он хлоргидрата, способ его получения, фармацевтическая композиция, способ лечения
GR3023936T3 (en) Heterocyclic alkylamides, process for their preparation and pharmaceutical compositions containing them
HUP0203841A3 (en) 5-membered heteroaromatic compounds and use thereof for preparation of pharmaceutical compositions, and pharmaceutical compositions containing them
GR3022116T3 (en) Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them
AU2673095A (en) {a}-annelated pyrrole derivatives and pharmaceutical use thereof
HU229443B1 (en) Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use
MXPA04002825A (es) Derivados de quinolina como antagonistas de neuropeptido y.
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
ES2076894A1 (es) Derivados de 2-(4-(4-azolibutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.
AU2672895A (en) (a)-annelated pyrrole derivatives and pharmaceutical use thereof
GEP20043179B (en) Halogenated Amidino Amino Acid Derivatives Useful as Nitric Oxide Synthase Inhibitors
PL294701A1 (es)
NO960632D0 (no) Nye bis-naftalimider for behandling av kreft
DE69302829D1 (de) Bicyclische pyrimidinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate
EP0410114A3 (en) Use of 4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)-1-(4-fluorophenyl)-butanol in pharmaceutical compositions for the treatment of ischemia in brain
AP9200443A0 (en) Heterocyclic compounds.
IL179865A0 (en) Pharmaceutical composition comprising 5 - [[4-[3 - methyl- 4- oxo - 3,4 - dihydro - 2 - quinazolinyl]methoxy] phenyl-methyl]thiadiazolidine-2,4- dione in the form of a tablet a powder or a capsule and the process for its preparation
DE69318715D1 (de) Pharmakologisch aktive alpha-(tertiär-aminoethyl)-phenylmethanol-derivate
YU31600A (sh) Pseudopolimorfni oblici 2-(2-(4-bis(4-fluorofenil)metil)-1-piperazinil)etoksi)sirćetne kiseline dihidrohlorida
TR199900013T2 (xx) Yeni bile�ikler.
AU1929688A (en) Leukotriene antagonists, processes for the preparation thereof, the use thereof for the treatment of diseases, and precursors
EP0523013A3 (en) Use of benzimidazoline-2-oxo-1-carboxylic acid derivatives in the treatment of organic mental diseases
DK0986390T3 (da) Farmaceutiske præparater med cinchosin-dihydrochlorid

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19940203

Kind code of ref document: B1

Effective date: 19940203

FD1A Patent lapsed

Effective date: 20020401