ES2077547T1 - Microesferas de liberacion prolongada que contienen farmaco antipsicotico y procedimiento para prepararlas. - Google Patents

Microesferas de liberacion prolongada que contienen farmaco antipsicotico y procedimiento para prepararlas.

Info

Publication number
ES2077547T1
ES2077547T1 ES93924827T ES93924827T ES2077547T1 ES 2077547 T1 ES2077547 T1 ES 2077547T1 ES 93924827 T ES93924827 T ES 93924827T ES 93924827 T ES93924827 T ES 93924827T ES 2077547 T1 ES2077547 T1 ES 2077547T1
Authority
ES
Spain
Prior art keywords
microsphere
preparing
procedure
biocompatible polymer
prolonged release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES93924827T
Other languages
English (en)
Other versions
ES2077547T3 (es
Inventor
Shigemi Yoshitomi Pharmac Kino
Tomonori Yoshitomi Pha Osajima
Hiroaki Yoshitomi Pharm Mizuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Yoshitomi Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18255017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2077547(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd
Publication of ES2077547T1 publication Critical patent/ES2077547T1/es
Application granted granted Critical
Publication of ES2077547T3 publication Critical patent/ES2077547T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

UNA MICROESFERA DE LIBERACION SOSTENIDA PRODUCIDA ENCERRANDO UN ANTIPSICOTICO HIDROFOBICO TAL COMO BROMOPERIDOL O HALOPERIDOL EN UNA BASE QUE COMPRENDE UN POLIMERO BIOCOMPATIBLE TAL COMO ACIDO POLILACTICO O UN COPOLIMERO DE ACIDO LACTICO/ACIDO GLICOLICO. PUEDE EXHIBIR UN DESEADO EFECTO FARMACOLOGICO, DONDE ES NECESARIA UNA ADMINISTRACION DE LARGA DURACION, INYECTANDO DE 1 A 8 SEMANAS, UNA VEZ POR SEMANA, EN LUGAR DE CADA DIA. COMO UN RESULTADO, PUEDE SER ESPERADA UNA IMPORTANTE MEJORA EN LA TOLERANCIA DURANTE TERAPIA SOSTENIDA. ADICIONALMENTE, EL USO DEL POLIMERO BIOCOMPATIBLE SIRVE PARA DISTRIBUIR INTEGRAMENTE CON OPERACIONES QUIRURGICAS TALES COMO IMPLANTACION, FACILIDADES HIPODERMICAS E INYECCION INTRAMUSCULAR JUSTO COMO EL CASO DE INYECCION PROLONGADA, Y SE PUEDE DISPENSAR CON EXTRACCION DE LA MICROESFERA. ADEMAS, LA MICROESFERA PUEDE SER ADMINISTRADA CON POCA AVERSION Y DOLOR.
ES93924827T 1992-11-17 1993-11-15 Microesfera de liberacion sostenida que contiene un antipsicotico y procedimiento de produccion. Expired - Lifetime ES2077547T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33244192 1992-11-17

Publications (2)

Publication Number Publication Date
ES2077547T1 true ES2077547T1 (es) 1995-12-01
ES2077547T3 ES2077547T3 (es) 2000-06-16

Family

ID=18255017

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93924827T Expired - Lifetime ES2077547T3 (es) 1992-11-17 1993-11-15 Microesfera de liberacion sostenida que contiene un antipsicotico y procedimiento de produccion.

Country Status (11)

Country Link
US (2) US5656299A (es)
EP (1) EP0669128B1 (es)
KR (1) KR100333115B1 (es)
AT (1) ATE188375T1 (es)
CA (1) CA2148823C (es)
DE (2) DE69327542T2 (es)
DK (1) DK0669128T3 (es)
ES (1) ES2077547T3 (es)
GR (2) GR960300020T1 (es)
PT (1) PT669128E (es)
WO (1) WO1994010982A1 (es)

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JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
IT1216570B (it) * 1988-04-08 1990-03-08 Vectorpharma Int Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione.

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EP0669128B1 (en) 2000-01-05
CA2148823A1 (en) 1994-05-26
KR950703936A (ko) 1995-11-17
PT669128E (pt) 2000-06-30
GR960300020T1 (en) 1996-03-31
WO1994010982A1 (fr) 1994-05-26
US5656299A (en) 1997-08-12
ATE188375T1 (de) 2000-01-15
ES2077547T3 (es) 2000-06-16
KR100333115B1 (ko) 2002-12-02
DK0669128T3 (da) 2000-06-19
DE669128T1 (de) 1996-03-14
US5871778A (en) 1999-02-16
CA2148823C (en) 1999-03-09
EP0669128A1 (en) 1995-08-30
GR3033016T3 (en) 2000-08-31
DE69327542T2 (de) 2000-07-06
EP0669128A4 (en) 1996-09-25
DE69327542D1 (de) 2000-02-10

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