ES2183172T3 - Procedimiento para la preparacion de microparticulas. - Google Patents

Procedimiento para la preparacion de microparticulas.

Info

Publication number
ES2183172T3
ES2183172T3 ES97923063T ES97923063T ES2183172T3 ES 2183172 T3 ES2183172 T3 ES 2183172T3 ES 97923063 T ES97923063 T ES 97923063T ES 97923063 T ES97923063 T ES 97923063T ES 2183172 T3 ES2183172 T3 ES 2183172T3
Authority
ES
Spain
Prior art keywords
microparticles
procedure
preparation
organic solvent
total weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97923063T
Other languages
English (en)
Inventor
Michael E Rickey
J Michael Ramstack
Danny H Lewis
Jean Louis Mesens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Original Assignee
Janssen Pharmaceutica NV
Alkermes Inc
Alkermes Controlled Therapeutics Inc II
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24582704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2183172(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV, Alkermes Inc, Alkermes Controlled Therapeutics Inc II filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2183172T3 publication Critical patent/ES2183172T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

LA PRESENTE INVENCION SUMINISTRA UN PROCESO PARA LA PREPARACION DE MICROPARTICULAS BIOCOMPATIBLES Y BIODEGRADABLES. DICHO PROCESO COMPRENDE: (1) PONER EN CONTACTO LAS MICROPARTICULAS, QUE CONTIENEN UNA MATRIZ POLIMERICA BIOCOMPATIBLE Y BIODEGRADABLE QUE A SU VEZ POSEE UN AGENTE ACTIVO (POR EJEMPLO, FARMACEUTICO O DIAGNOSTICO) Y UN DISOLVENTE ORGANICO, CON UN SISTEMA DISOLVENTE ACUOSO, DONDE EL CONTENIDO DE DICHO DISOLVENTE EN DICHAS MICROPARTICULAS SE REDUCE A UN PESO IGUAL O INFERIOR AL 2 % DEL PESO DE TALES PARTICULAS Y ADEMAS EL SISTEMA DISOLVENTE TIENE QUE SATISFACER AL MENOS UNA DE LAS SIGUIENTES CONDICIONES: (A) QUE ESTE A UNA TEMPERATURA ELEVADA (POR EJEMPLO, DE 25 A 40°C) DURANTE, AL MENOS, PARTE DEL TIEMPO EN QUE SE PONE EN CONTACTO CON DICHAS PARTICULAS, Y (B) QUE CONTENGA AGUA Y DISOLVENTE MISCIBLE EN AGUA PARA DICHO DISOLVENTE ORGANICO; Y (2) RECUPERAR DICHAS PARTICULAS A PARTIR DE TAL SISTEMA DISOLVENTE ACUOSO.
ES97923063T 1996-05-07 1997-05-06 Procedimiento para la preparacion de microparticulas. Expired - Lifetime ES2183172T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64391996A 1996-05-07 1996-05-07

Publications (1)

Publication Number Publication Date
ES2183172T3 true ES2183172T3 (es) 2003-03-16

Family

ID=24582704

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97923063T Expired - Lifetime ES2183172T3 (es) 1996-05-07 1997-05-06 Procedimiento para la preparacion de microparticulas.
ES02075905T Expired - Lifetime ES2284776T3 (es) 1996-05-07 1997-05-06 Microparticulas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES02075905T Expired - Lifetime ES2284776T3 (es) 1996-05-07 1997-05-06 Microparticulas.

Country Status (11)

Country Link
EP (1) EP1210942B1 (es)
AT (2) ATE357218T1 (es)
CY (1) CY2318B1 (es)
DE (2) DE69715191T2 (es)
DK (2) DK0904063T3 (es)
ES (2) ES2183172T3 (es)
HK (1) HK1047539B (es)
MY (1) MY118174A (es)
PT (2) PT904063E (es)
SI (2) SI0904063T1 (es)
TR (1) TR199802258T2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
BR0212833A (pt) 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
EP2167039B1 (en) 2007-05-18 2016-09-28 Durect Corporation Improved depot formulations
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
ES2562878T3 (es) 2007-05-25 2016-03-08 Indivior Uk Limited Formulaciones de liberación sostenida de compuestos de risperidona
EA033537B1 (ru) 2013-03-11 2019-10-31 Durect Corp Инъекционная композиция с контролируемым высвобождением, содержащая жидкий носитель с высокой вязкостью
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN104226191B (zh) * 2014-09-01 2017-04-19 南京理工大学 乙基纤维素多孔颗粒的常温制备方法
WO2019209883A1 (en) * 2018-04-23 2019-10-31 Graybug Vision, Inc. Improved continuous microparticle manufacture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US5478564A (en) * 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
DE69327542T2 (de) * 1992-11-17 2000-07-06 Yoshitomi Pharmaceutical Industries, Ltd. Ein antipsychotikum enthaltende mikrokugel zur verzögerten freisetzung und verfahren für ihre herstellung
EP0724433B1 (en) * 1993-10-22 1998-12-30 Genentech, Inc. Method for preparing microspheres comprising a fluidized bed drying step
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
EP2283821A1 (en) * 1993-11-19 2011-02-16 Alkermes, Inc. Preparation of biodegradable microparticles containing a biologically active agent

Also Published As

Publication number Publication date
DE69737515D1 (de) 2007-05-03
DE69737515T2 (de) 2007-12-06
DK0904063T3 (da) 2002-12-16
EP1210942A2 (en) 2002-06-05
DE69715191T2 (de) 2003-04-30
DE69715191D1 (de) 2002-10-10
SI1210942T1 (sl) 2007-10-31
ES2284776T3 (es) 2007-11-16
PT1210942E (pt) 2007-06-26
PT904063E (pt) 2003-01-31
ATE357218T1 (de) 2007-04-15
CY2318B1 (en) 2003-11-14
HK1047539A1 (en) 2003-02-28
EP1210942A3 (en) 2004-05-26
HK1047539B (en) 2007-08-24
DK1210942T3 (da) 2007-07-23
EP1210942B1 (en) 2007-03-21
MY118174A (en) 2004-09-30
TR199802258T2 (en) 2001-11-21
HK1016884A1 (en) 1999-11-12
ATE223206T1 (de) 2002-09-15
SI0904063T1 (en) 2003-02-28

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