ES2077577T3 - Compuestos complejos de porfirina sustituidos en posiciones 13,17 con acido propionico y derivados de acido propionico, procedimiento para su preparacion y agentes farmaceuticos que los contienen. - Google Patents

Compuestos complejos de porfirina sustituidos en posiciones 13,17 con acido propionico y derivados de acido propionico, procedimiento para su preparacion y agentes farmaceuticos que los contienen.

Info

Publication number
ES2077577T3
ES2077577T3 ES89250013T ES89250013T ES2077577T3 ES 2077577 T3 ES2077577 T3 ES 2077577T3 ES 89250013 T ES89250013 T ES 89250013T ES 89250013 T ES89250013 T ES 89250013T ES 2077577 T3 ES2077577 T3 ES 2077577T3
Authority
ES
Spain
Prior art keywords
propionic acid
porphirin
replaced
procedure
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89250013T
Other languages
English (en)
Inventor
Ulrich Dr Niedballa
Heinz Dr Gries
Jurgen Dr Conrad
Ulrich Prof Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2077577T3 publication Critical patent/ES2077577T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/803—Stabe free radicals, e.g. spin immunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PORPHYRIN-COMPUESTOS COMPLEJOS, COMPUESTOS DE POR LO MENOS UN PORPHIRINLIGANDEN, CASO DADO POR LO MENOS DE UN ION DE UN ELEMENTO DE LAS CIFRAS ORDINARIAS 5, 13, 21-32, 37-39, 42-44, 49-50 O 57-83 ASI COMO EN CASO DADO CATIONES DE BASES INORGANICAS Y/O ORGANICAS, AMINOACIDOS O AMINOACIDOSAMIDAS, SON VALIOSOS EN DIAGNOSTICO Y TERAPEUTICA.
ES89250013T 1988-08-13 1989-08-11 Compuestos complejos de porfirina sustituidos en posiciones 13,17 con acido propionico y derivados de acido propionico, procedimiento para su preparacion y agentes farmaceuticos que los contienen. Expired - Lifetime ES2077577T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3827940A DE3827940A1 (de) 1988-08-13 1988-08-13 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
ES2077577T3 true ES2077577T3 (es) 1995-12-01

Family

ID=6361054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89250013T Expired - Lifetime ES2077577T3 (es) 1988-08-13 1989-08-11 Compuestos complejos de porfirina sustituidos en posiciones 13,17 con acido propionico y derivados de acido propionico, procedimiento para su preparacion y agentes farmaceuticos que los contienen.

Country Status (14)

Country Link
US (1) US5275801A (es)
EP (1) EP0355041B1 (es)
JP (1) JPH02160789A (es)
AT (1) ATE128138T1 (es)
DE (2) DE3827940A1 (es)
DK (1) DK395289A (es)
ES (1) ES2077577T3 (es)
GR (1) GR3017586T3 (es)
IE (1) IE70229B1 (es)
IL (1) IL91292A0 (es)
NO (1) NO172238C (es)
NZ (1) NZ230288A (es)
PT (1) PT91422B (es)
ZA (1) ZA896187B (es)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5972307A (en) * 1989-10-23 1999-10-26 Nycomed Salutar, Inc. Dichelants
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
US5262532A (en) * 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
DE4232925A1 (de) * 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
DE4303969B4 (de) * 1993-02-10 2006-01-19 Oped Gmbh Schuh, insbesondere Skischuh
DE4403789A1 (de) * 1994-02-03 1995-08-10 Schering Ag Mittel zur visuellen Markierung von Körpergewebe
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
US6444194B1 (en) * 1997-02-14 2002-09-03 Miravant Pharmaceuticals, Inc. Indium photosensitizers for PDT
US6194566B1 (en) 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
DE19845782C1 (de) * 1998-09-22 2000-04-13 Schering Ag Verfahren zur Herstellung von Metallporphyrin-Metallkomplex-Konjugaten
EP0953360B1 (en) * 1998-03-24 2004-05-26 Council of Scientific and Industrial Research Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
US6136841A (en) * 1998-06-02 2000-10-24 Schering Aktiengesellschaft 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production and their use in photodynamic therapy and MRI diagnosis
DE19825512A1 (de) * 1998-06-02 1999-12-09 Schering Ag 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
ATE255583T1 (de) * 1998-07-10 2003-12-15 Meiji Seika Kaisha Metallkomplexe von chlorinderivaten zum abschirmen von röntgenstrahlen
DE19835082A1 (de) * 1998-07-24 2000-02-03 Schering Ag Paramagnetische 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung für das Nekrose- und Infarkt-MR-Imaging
US6251367B1 (en) 1998-07-24 2001-06-26 Schering Aktiengesellschaft Paramagnetic 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
FI982422A0 (fi) 1998-11-09 1998-11-09 Arctic Diagnostics Oy Porfyriiniyhdisteitä, niiden konjugaatit sekä määritysmenetelmiä pohjautuen näiden konjugaattien käyttöön
HK1040993B (en) * 1999-04-30 2006-11-10 Cellgate, Inc. Polyamines and their use in therapy
US6548045B2 (en) * 1999-11-30 2003-04-15 Photochemical Co., Ltd. Nitroimidazole substituted porphyrin complex
US6605090B1 (en) * 2000-10-25 2003-08-12 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
EP1349865A2 (en) * 2000-12-15 2003-10-08 Mitokor Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
CA2448570A1 (en) * 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US7375216B2 (en) * 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
US7026347B2 (en) * 2002-06-26 2006-04-11 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
DE10240343A1 (de) * 2002-08-27 2004-03-11 Schering Ag Peroxynitrit-Umlagerungskatalysatoren
US20040127479A1 (en) * 2002-08-27 2004-07-01 Merck Patent Gmbh Peroxynitrite rearrangement catalysts
US20040097481A1 (en) * 2002-11-20 2004-05-20 Benjamin Levinson Water-soluble mesoporphyrin compounds and methods of preparation
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
CN101573122B (zh) 2006-10-04 2016-08-03 婴儿护理药品公司 锡泊芬的高纯度大规模制备
PT2691398T (pt) 2011-03-30 2017-01-02 Infacare Pharmaceutical Corp Métodos para sintetizar mesoporfirinas de metal
CN102363619A (zh) * 2011-11-18 2012-02-29 中国医学科学院生物医学工程研究所 水溶性原卟啉化合物及制备方法及用途
CN115894301B (zh) * 2022-10-25 2024-08-13 武汉大学中南医院 一种二聚化钆基t1磁共振对比造影剂及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156840A (en) * 1982-03-09 1992-10-20 Cytogen Corporation Amine-containing porphyrin derivatives
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
AU583854B2 (en) * 1984-09-13 1989-05-11 Cytogen Corporation Antibody therapeutic agent conjugates
US4986256A (en) * 1985-02-28 1991-01-22 The United States Of America As Represented By The Department Of Health And Human Services Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
EP0220686B1 (en) * 1985-10-23 1992-12-30 Nihon Medi-Physics Co., Ltd. Porphyrin derivatives, and their production and use
US4923437A (en) * 1986-07-18 1990-05-08 Gordon Robert T Process for applying a localized magnetic or electric field
US4882234A (en) * 1986-11-12 1989-11-21 Healux, Inc. Storage-stable porphin compositions and a method for their manufacture
JPH0786109B2 (ja) * 1987-12-21 1995-09-20 浜理薬品工業株式会社 フェオフォルバイド誘導体
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
DE68928607T2 (de) * 1988-07-14 1998-07-23 Toyohakka Kogyo K K Porphyrinderivate

Also Published As

Publication number Publication date
EP0355041B1 (de) 1995-09-20
DE3827940A1 (de) 1990-03-01
GR3017586T3 (en) 1995-12-31
NO172238B (no) 1993-03-15
US5275801A (en) 1994-01-04
IE892605L (en) 1990-02-13
EP0355041A2 (de) 1990-02-21
PT91422A (pt) 1990-03-08
DE58909444D1 (de) 1995-10-26
JPH02160789A (ja) 1990-06-20
DK395289D0 (da) 1989-08-11
AU622470B2 (en) 1992-04-09
ATE128138T1 (de) 1995-10-15
AU3957089A (en) 1990-02-15
NZ230288A (en) 1992-06-25
EP0355041A3 (de) 1991-07-24
IL91292A0 (en) 1990-03-19
NO893245D0 (no) 1989-08-11
ZA896187B (en) 1990-05-30
PT91422B (pt) 1995-05-31
IE70229B1 (en) 1996-11-13
DK395289A (da) 1990-02-14
NO893245L (no) 1990-02-14
NO172238C (no) 1993-06-23

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