ES2077700T3 - Anticuerpos monoclonales contra formadores de complejos complejados y no complejados para la eliminacion de metales pesados a partir de soluciones acuosas y para la analitica. - Google Patents

Anticuerpos monoclonales contra formadores de complejos complejados y no complejados para la eliminacion de metales pesados a partir de soluciones acuosas y para la analitica.

Info

Publication number
ES2077700T3
ES2077700T3 ES91103138T ES91103138T ES2077700T3 ES 2077700 T3 ES2077700 T3 ES 2077700T3 ES 91103138 T ES91103138 T ES 91103138T ES 91103138 T ES91103138 T ES 91103138T ES 2077700 T3 ES2077700 T3 ES 2077700T3
Authority
ES
Spain
Prior art keywords
complex
monoclonal antibodies
aqueous solutions
heavy metals
dtpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91103138T
Other languages
English (en)
Inventor
Klaus Dr Bosslet
Peter Dr Hermentin
Gerhard Dr Seemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2077700T3 publication Critical patent/ES2077700T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Removal Of Specific Substances (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

LA INVENCION SE REFIERE A UN ANTICUERPO MONOCLONAL (MAK), QUE SE UNE CON ALTA ESPECIFICACION Y ACTIVIDAD A UNA COMPLEXION ACUOSA COMO TETRACETATODIAMINICOETILENO (EDTA) O PENTAACETATOTRIAMINODIETILENO (DTPA) Y MANTIENE SU ALTA ACTIVIDAD Y ESPECIFICACION, EN ESTOS COMPLEJOS TRAS LA COMPLEXION DEL EDTA O DTPA CON IONES METALICOS. ESTOS MAK PUEDEN LLEGAR A SER UTILIZADOS ADEMAS, POR EJEMPLO ACOPLADO EN UN FILTRO O EN DIFERENTES PORTADORES PARA LA ELIMINACION DE METALES PESADOS TOXICOS, QUE ESTAN AGRUPADOS CON EDTA O DTPA. POR ESO ESTOS MAK SON APROPIADOS COMO COMPONENTES DE ASSAYS COMUNES (RIA, ELISA, ETC) PARA LA PRUEBA CUANTITATIVA DE EDTA ASI COMO DE EDTA EN SOLUCIONES ACUOSAS.
ES91103138T 1990-03-07 1991-03-02 Anticuerpos monoclonales contra formadores de complejos complejados y no complejados para la eliminacion de metales pesados a partir de soluciones acuosas y para la analitica. Expired - Lifetime ES2077700T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4007079A DE4007079A1 (de) 1990-03-07 1990-03-07 Monoklonale antikoerper gegen komplexierte und nicht komplexierte komplexbildner zur entfernung von schwermetallen aus waessrigen loesungen

Publications (1)

Publication Number Publication Date
ES2077700T3 true ES2077700T3 (es) 1995-12-01

Family

ID=6401563

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91103138T Expired - Lifetime ES2077700T3 (es) 1990-03-07 1991-03-02 Anticuerpos monoclonales contra formadores de complejos complejados y no complejados para la eliminacion de metales pesados a partir de soluciones acuosas y para la analitica.

Country Status (13)

Country Link
US (2) US5907034A (es)
EP (1) EP0446730B1 (es)
JP (1) JP3065370B2 (es)
KR (1) KR100210720B1 (es)
AT (1) ATE127848T1 (es)
AU (1) AU651962B2 (es)
CA (1) CA2037664C (es)
DE (2) DE4007079A1 (es)
DK (1) DK0446730T3 (es)
ES (1) ES2077700T3 (es)
GR (1) GR3017741T3 (es)
IE (1) IE68044B1 (es)
PT (1) PT96945B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
EP1351989A2 (en) * 2000-12-15 2003-10-15 Transderm Technologies LLC Improved compositions and methods for producing antibodies to low molecular weight analytes
US7700295B2 (en) * 2000-12-28 2010-04-20 Mds Sciex Elemental analysis of tagged biologically active materials
US7135296B2 (en) * 2000-12-28 2006-11-14 Mds Inc. Elemental analysis of tagged biologically active materials
KR101039793B1 (ko) 2003-08-22 2011-06-09 학교법인 포항공과대학교 중금속 내성 Ｐｃｒ 유전자 및 그 유전자로 형질전환된 생물
US20070166774A1 (en) * 2006-01-17 2007-07-19 Groman Ernest V Functional immunoassay
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
KR101139431B1 (ko) 2011-05-30 2012-04-27 (주)비씨월드제약 이매티닙 염기의 신규한 제조방법
CN103529210B (zh) * 2013-09-27 2017-07-14 河南科技学院 一种用于检测样品中重金属离子锌离子含量的酶联免疫试剂盒
CN108387537A (zh) * 2018-02-01 2018-08-10 中国科学院广州生物医药与健康研究院 一种重金属离子的定量检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722892A (en) * 1984-08-31 1988-02-02 Meares Claude F Monoclonal antibodies against metal chelates
US4772892A (en) * 1984-11-13 1988-09-20 Raytheon Company Two-axis gimbal
GB8530829D0 (en) * 1985-12-13 1986-01-22 Syngene International Nv Monoclonal antibodies
JPH03504499A (ja) * 1988-05-27 1991-10-03 セントカー・インコーポレーテツド 抗体試薬のための配合物
AU648022B2 (en) * 1989-03-14 1994-04-14 Bionebraska, Inc. Monoclonal antibodies for metallic cations on small molecules

Also Published As

Publication number Publication date
CA2037664A1 (en) 1991-09-08
AU651962B2 (en) 1994-08-11
PT96945A (pt) 1991-10-31
IE68044B1 (en) 1996-05-15
GR3017741T3 (en) 1996-01-31
KR100210720B1 (ko) 1999-07-15
ATE127848T1 (de) 1995-09-15
PT96945B (pt) 1998-07-31
US5908790A (en) 1999-06-01
JP3065370B2 (ja) 2000-07-17
EP0446730B1 (de) 1995-09-13
AU7264491A (en) 1991-09-12
DE59106448D1 (de) 1995-10-19
DK0446730T3 (da) 1996-01-22
IE910750A1 (en) 1991-09-11
US5907034A (en) 1999-05-25
JPH04218390A (ja) 1992-08-07
KR910016341A (ko) 1991-11-05
DE4007079A1 (de) 1991-09-12
EP0446730A1 (de) 1991-09-18
CA2037664C (en) 2002-05-21

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