ES2079320B1 - Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones. - Google Patents

Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.

Info

Publication number
ES2079320B1
ES2079320B1 ES09401078A ES9401078A ES2079320B1 ES 2079320 B1 ES2079320 B1 ES 2079320B1 ES 09401078 A ES09401078 A ES 09401078A ES 9401078 A ES9401078 A ES 9401078A ES 2079320 B1 ES2079320 B1 ES 2079320B1
Authority
ES
Spain
Prior art keywords
diclofenaco
tobramycin
applications
dissolution based
ophthalmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09401078A
Other languages
English (en)
Other versions
ES2079320A1 (es
Inventor
Cabrera Antonio Lopez
Cabello Gemma Torrella
Mas Jose Alberto Vallet
Michael Van Wie Bergamini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES09401078A priority Critical patent/ES2079320B1/es
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to PT94926248T priority patent/PT711546E/pt
Priority to AT94926248T priority patent/ATE198417T1/de
Priority to PCT/ES1994/000084 priority patent/WO1995031179A1/es
Priority to EP94926248A priority patent/EP0711546B1/en
Priority to CA002167383A priority patent/CA2167383C/en
Priority to HU9600095A priority patent/HUT74164A/hu
Priority to BR9407330A priority patent/BR9407330A/pt
Priority to AU76160/94A priority patent/AU696853B2/en
Priority to PL94312615A priority patent/PL312615A1/xx
Priority to CN94193294A priority patent/CN1098678C/zh
Priority to DE69426529T priority patent/DE69426529T2/de
Priority to DK94926248T priority patent/DK0711546T3/da
Priority to HK98113200.2A priority patent/HK1017806B/en
Priority to KR1019960700285A priority patent/KR100353377B1/ko
Priority to US08/419,387 priority patent/US5597560A/en
Publication of ES2079320A1 publication Critical patent/ES2079320A1/es
Priority to OA60766A priority patent/OA10570A/en
Priority to NO960207A priority patent/NO308645B1/no
Priority to BG100289A priority patent/BG100289A/xx
Priority to FI960232A priority patent/FI116884B/fi
Application granted granted Critical
Publication of ES2079320B1 publication Critical patent/ES2079320B1/es
Priority to GR20010400478T priority patent/GR3035633T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DISOLUCION OFTALMICA A BASE DE DICLOFENACO Y TOBRAMICINA Y SUS APLICACIONES. COMPRENDE: (A) EL EQUIVALENTE A UN VALOR DE 0,001-0,14 POR CIENTO DE DICLOFENACO, PROVENIENTE DEL PROPIO DICLOFENACO O DE UN ISOMERO, O UN DERIVADO, O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; (B) EL EQUIVALENTE A UN VALOR DE 0,001-0,45 POR CIENTO DE TOBRAMICINA, PROVENIENTE DE LA PROPIA TOBRAMICINA O DE UN ISOMERO O UN DERIVADO O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; Y (C) OPCIONALMENTE UN AGENTE SOLUBILIZANTE, ISOTONIZANTE, AMORTIGUADOR DEL PH, VISCOSIZANTE, QUELANTE, CONSERVADOR, Y/O UN EXCIPIENTE PARA HIDROGENES FARMACEUTICOS. APLICACION EN EL TRATAMIENTO DE LAS INFLAMACIONES Y/O INFECCIONES OCULARES Y OTICAS.
ES09401078A 1994-05-17 1994-05-17 Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones. Expired - Fee Related ES2079320B1 (es)

Priority Applications (21)

Application Number Priority Date Filing Date Title
ES09401078A ES2079320B1 (es) 1994-05-17 1994-05-17 Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.
HK98113200.2A HK1017806B (en) 1994-05-17 1994-09-07 Ophthalmic solution based on diclofenac and tobramcine and its applications
PCT/ES1994/000084 WO1995031179A1 (es) 1994-05-17 1994-09-07 Disolucion oftalmica a base de diclofenaco y tobramicina y sus aplicaciones
EP94926248A EP0711546B1 (en) 1994-05-17 1994-09-07 Ophthalmic solution based on diclofenac and tobramycine and its applications
CA002167383A CA2167383C (en) 1994-05-17 1994-09-07 Ophthalmic solution based on diclofenac and tobramycine and its applications
HU9600095A HUT74164A (en) 1994-05-17 1994-09-07 Ophtalmic solution based on diclofenac and tobramicine and its applications
BR9407330A BR9407330A (pt) 1994-05-17 1994-09-07 Solução oftálmica baseada em diclofenaco e tobramicina e formulação oftálmica
AT94926248T ATE198417T1 (de) 1994-05-17 1994-09-07 Ophthalmische lösung, die diclofenac und tobramycin enthält, und ihre verwendung
PL94312615A PL312615A1 (en) 1994-05-17 1994-09-07 Ophthalmologic solution based on diclofenac and tobramycine, and its applications
CN94193294A CN1098678C (zh) 1994-05-17 1994-09-07 以双氯灭痛和妥布霉素为基础的眼用溶液及其应用
PT94926248T PT711546E (pt) 1994-05-17 1994-09-07 Solucao oftalmica baseada em diclofenac e tobramicina e as suas aplicacoes
DK94926248T DK0711546T3 (da) 1994-05-17 1994-09-07 Ophthalmisk opløsning på grundlag af diclofenac og tobramycin samt dens anvendelse
AU76160/94A AU696853B2 (en) 1994-05-17 1994-09-07 Ophtalmic solution based on diclofenac and tobramycin and its applications
DE69426529T DE69426529T2 (de) 1994-05-17 1994-09-07 Ophthalmische lösung, die diclofenac und tobramycin enthält, und ihre verwendung
KR1019960700285A KR100353377B1 (ko) 1994-05-17 1994-09-07 디클로페낙및토브라마이신을기재로하는약액
US08/419,387 US5597560A (en) 1994-05-17 1995-04-10 Diclofenac and tobramycin formulations for ophthalmic and otic topicaluse
OA60766A OA10570A (en) 1994-05-17 1996-01-17 Ophtalmic solution based on diclofenac and tobramycin and its applications
NO960207A NO308645B1 (no) 1994-05-17 1996-01-17 Oftalmisk løsning basert pÕ diclofenac og tobramycin samt anvendelse av denne
BG100289A BG100289A (bg) 1994-05-17 1996-01-17 Разтвор на базата на диклофен и тобрамицин и неговите приложения
FI960232A FI116884B (fi) 1994-05-17 1996-01-17 Menetelmä diklofenaakkiin ja tobramysiiniin perustuvan silmätippaliuoksen valmistamiseksi
GR20010400478T GR3035633T3 (en) 1994-05-17 2001-03-23 Ophtalmic solution based on diclofenac and tobramicine and its applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09401078A ES2079320B1 (es) 1994-05-17 1994-05-17 Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.

Publications (2)

Publication Number Publication Date
ES2079320A1 ES2079320A1 (es) 1996-01-01
ES2079320B1 true ES2079320B1 (es) 1996-10-16

Family

ID=8286285

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401078A Expired - Fee Related ES2079320B1 (es) 1994-05-17 1994-05-17 Disolucion oftalmica a base de un diclofenaco y tobramicina y sus aplicaciones.

Country Status (20)

Country Link
US (1) US5597560A (es)
EP (1) EP0711546B1 (es)
KR (1) KR100353377B1 (es)
CN (1) CN1098678C (es)
AT (1) ATE198417T1 (es)
AU (1) AU696853B2 (es)
BG (1) BG100289A (es)
BR (1) BR9407330A (es)
CA (1) CA2167383C (es)
DE (1) DE69426529T2 (es)
DK (1) DK0711546T3 (es)
ES (1) ES2079320B1 (es)
FI (1) FI116884B (es)
GR (1) GR3035633T3 (es)
HU (1) HUT74164A (es)
NO (1) NO308645B1 (es)
OA (1) OA10570A (es)
PL (1) PL312615A1 (es)
PT (1) PT711546E (es)
WO (1) WO1995031179A1 (es)

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EP0711546A1 (en) 1996-05-15
BG100289A (bg) 1996-12-31
HUT74164A (en) 1996-11-28
AU7616094A (en) 1995-12-05
NO308645B1 (no) 2000-10-09
KR960703581A (ko) 1996-08-31
CA2167383C (en) 2001-11-20
CN1130351A (zh) 1996-09-04
FI960232A0 (fi) 1996-01-17
HK1017806A1 (en) 1999-11-26
CN1098678C (zh) 2003-01-15
PL312615A1 (en) 1996-04-29
NO960207L (no) 1996-03-15
AU696853B2 (en) 1998-09-17
OA10570A (en) 2002-06-20
ATE198417T1 (de) 2001-01-15
GR3035633T3 (en) 2001-06-29
NO960207D0 (no) 1996-01-17
EP0711546B1 (en) 2001-01-03
CA2167383A1 (en) 1995-11-23
WO1995031179A1 (es) 1995-11-23
KR100353377B1 (ko) 2002-12-26
BR9407330A (pt) 1996-06-18
FI116884B (fi) 2006-03-31
DE69426529T2 (de) 2001-08-09
ES2079320A1 (es) 1996-01-01
US5597560A (en) 1997-01-28
PT711546E (pt) 2001-06-29
DK0711546T3 (da) 2001-04-23
FI960232L (fi) 1996-03-15
DE69426529D1 (de) 2001-02-08

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