ES2079534T3 - Derivados de polietilenglicol, sus peptidos modificados, metodos para producirlos y uso de los peptidos modificados. - Google Patents

Derivados de polietilenglicol, sus peptidos modificados, metodos para producirlos y uso de los peptidos modificados.

Info

Publication number
ES2079534T3
ES2079534T3 ES91114221T ES91114221T ES2079534T3 ES 2079534 T3 ES2079534 T3 ES 2079534T3 ES 91114221 T ES91114221 T ES 91114221T ES 91114221 T ES91114221 T ES 91114221T ES 2079534 T3 ES2079534 T3 ES 2079534T3
Authority
ES
Spain
Prior art keywords
modified peptides
polyethylene glycol
derivatives
methods
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91114221T
Other languages
English (en)
Inventor
Yoshiharu Ikeda
Yoshiyuki Kai
Keiichi Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2079534T3 publication Critical patent/ES2079534T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
    • C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/3311—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group
    • C08G65/3314—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic
    • C08G65/3315—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic
    • C08G65/3317—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic phenolic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)

Abstract

SON DERIVADOS DEL GLICOL POLIETILENO DE FORMULA: DONDE R SUB 1 Y R SUB 2 SON LOS MISMOS O DIFERENTES Y CADA UNO REPRESENTA UN ALQUILO BAJO, M Y N SON LOS MISMOS O DIFERENTES Y CADA UNO REPRESENTA UN NUMERO POSITIVO, Y P ES O O UN NUMERO POSITIVO, SON PEPTIDOS MODIFICADOS DE DERIVADOS DEL GLICOL POLIETILENO, METODOS PARA SU PRODUCCION Y UTILIZACION DE LOS PEPTIDOS MODIFICADOS. LOS PEPTIDOS MODIFICADOS POR LOS DERIVADOS DEL GLICOL POLIETILENO (I) DE ESTA INVENCION COMPARADOS CON LOS PEPTIDOS MODIFICADOS MUESTRAN UNA ANTIGENECIDAD DECRECIENTE, SON CONSIDERADOS RETRASADOS EN APERTURAS BIOLOGICAS Y MUESTRAN EFECTIVAMENTE SUS ACTIVIDADES FISIOLOGICAS DURANTE UN LARGO PERIODO DE TIEMPO, SIENDO MUY EFECTIVOS COMO FARMACOS Y MEDICINAS PARA ANIMALES.
ES91114221T 1990-08-28 1991-08-24 Derivados de polietilenglicol, sus peptidos modificados, metodos para producirlos y uso de los peptidos modificados. Expired - Lifetime ES2079534T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2227541A JP3051145B2 (ja) 1990-08-28 1990-08-28 新規なポリエチレングリコール誘導体修飾ペプチド

Publications (1)

Publication Number Publication Date
ES2079534T3 true ES2079534T3 (es) 1996-01-16

Family

ID=16862521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91114221T Expired - Lifetime ES2079534T3 (es) 1990-08-28 1991-08-24 Derivados de polietilenglicol, sus peptidos modificados, metodos para producirlos y uso de los peptidos modificados.

Country Status (9)

Country Link
US (1) US5183660A (es)
EP (1) EP0473084B1 (es)
JP (1) JP3051145B2 (es)
AT (1) ATE130327T1 (es)
CA (1) CA2050063A1 (es)
DE (1) DE69114614T2 (es)
DK (1) DK0473084T3 (es)
ES (1) ES2079534T3 (es)
GR (1) GR3018612T3 (es)

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EP0473084B1 (en) 1995-11-15
CA2050063A1 (en) 1992-03-01
EP0473084A3 (en) 1992-04-29
JP3051145B2 (ja) 2000-06-12
ATE130327T1 (de) 1995-12-15
JPH04108827A (ja) 1992-04-09
US5183660A (en) 1993-02-02
DE69114614T2 (de) 1996-03-28
DE69114614D1 (de) 1995-12-21

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