ATE130327T1 - Polyethylenglykolderivate, modifizierte peptide derselben, ihre herstellung sowie verwendung der modifizierten peptide. - Google Patents
Polyethylenglykolderivate, modifizierte peptide derselben, ihre herstellung sowie verwendung der modifizierten peptide.Info
- Publication number
- ATE130327T1 ATE130327T1 AT91114221T AT91114221T ATE130327T1 AT E130327 T1 ATE130327 T1 AT E130327T1 AT 91114221 T AT91114221 T AT 91114221T AT 91114221 T AT91114221 T AT 91114221T AT E130327 T1 ATE130327 T1 AT E130327T1
- Authority
- AT
- Austria
- Prior art keywords
- polyethylene glycol
- modified peptides
- glycol derivatives
- same
- peptides
- Prior art date
Links
- 239000002202 Polyethylene glycol Substances 0.000 title abstract 4
- 108091005601 modified peptides Proteins 0.000 title abstract 4
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title 1
- 150000002334 glycols Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
- C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/3311—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group
- C08G65/3314—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic
- C08G65/3315—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic
- C08G65/3317—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic phenolic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2227541A JP3051145B2 (ja) | 1990-08-28 | 1990-08-28 | 新規なポリエチレングリコール誘導体修飾ペプチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE130327T1 true ATE130327T1 (de) | 1995-12-15 |
Family
ID=16862521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91114221T ATE130327T1 (de) | 1990-08-28 | 1991-08-24 | Polyethylenglykolderivate, modifizierte peptide derselben, ihre herstellung sowie verwendung der modifizierten peptide. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5183660A (de) |
| EP (1) | EP0473084B1 (de) |
| JP (1) | JP3051145B2 (de) |
| AT (1) | ATE130327T1 (de) |
| CA (1) | CA2050063A1 (de) |
| DE (1) | DE69114614T2 (de) |
| DK (1) | DK0473084T3 (de) |
| ES (1) | ES2079534T3 (de) |
| GR (1) | GR3018612T3 (de) |
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| US20210221886A1 (en) | 2019-12-05 | 2021-07-22 | Sorrento Therapeutics, Inc. | Compositions and Methods Comprising an Anti-CD47 Antibody in Combination with a Tumor Targeting Antibody |
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| CA3168986A1 (en) | 2020-02-26 | 2021-09-02 | Sorrento Therapeutics, Inc. | Activatable antigen binding proteins with universal masking moieties |
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| WO2021195089A1 (en) | 2020-03-23 | 2021-09-30 | Sorrento Therapeutics, Inc. | Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof |
| WO2021231447A1 (en) | 2020-05-12 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Novel il10 agonists and methods of use thereof |
| US11241410B2 (en) * | 2020-05-18 | 2022-02-08 | Amanuel Tesfazion | Method and compound for the treatment of covid-19 |
| US20230235059A1 (en) | 2020-06-26 | 2023-07-27 | Sorrento Therapeutics, Inc. | Anti-pd1 antibodies and uses thereof |
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| KR20240099460A (ko) | 2021-11-11 | 2024-06-28 | 리제너론 파아마슈티컬스, 인크. | Cd20-pd1 결합 분자 및 이의 사용 방법 |
| EP4709756A1 (de) | 2023-05-10 | 2026-03-18 | Regeneron Pharmaceuticals, Inc. | Cd20-pd1-bindende moleküle und verfahren zur verwendung davon |
| AU2024308069A1 (en) | 2023-06-27 | 2026-02-05 | Firecyte Therapeutics, Inc. | Insulin-like growth factor binding protein like 1 (igfbpl1) compositions and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE32439B1 (en) * | 1967-09-27 | 1973-08-08 | Madan Ag | Substituted phenylacetic acids and process of preparation thereof |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4268442A (en) * | 1978-11-14 | 1981-05-19 | Sagami Chemical Research Center | Process for preparing aromatic acetic acid |
| DE3125059A1 (de) * | 1981-06-26 | 1983-01-05 | Bayer Ag, 5090 Leverkusen | Dioxybenzoletherderivate, diese enthaltende arzneimittel, verfahren zu ihrer herstellung und ihre verwendung |
| DE3572982D1 (en) * | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| JPS6142558A (ja) * | 1984-08-06 | 1986-03-01 | Matsushita Electric Works Ltd | アミノ樹脂成形材料 |
| ES8800982A1 (es) * | 1985-07-05 | 1987-12-01 | Takeda Chemical Industries Ltd | Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina. |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| JPS63146791A (ja) * | 1986-12-08 | 1988-06-18 | Hitachi Ltd | 酵素の固定化方法 |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| IT1216473B (it) * | 1988-02-29 | 1990-03-08 | Montefibre Spa | Derivati poliossialchilen_etere_terminati di acidi organici, loro esteri alchilici e loro sali alcalini e alcalino terrosi. |
| CA1340810C (en) * | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| JP2958019B2 (ja) * | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
| JP2997004B2 (ja) * | 1989-05-26 | 2000-01-11 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
-
1990
- 1990-08-28 JP JP2227541A patent/JP3051145B2/ja not_active Expired - Lifetime
-
1991
- 1991-08-15 US US07/745,496 patent/US5183660A/en not_active Expired - Fee Related
- 1991-08-24 ES ES91114221T patent/ES2079534T3/es not_active Expired - Lifetime
- 1991-08-24 EP EP91114221A patent/EP0473084B1/de not_active Expired - Lifetime
- 1991-08-24 AT AT91114221T patent/ATE130327T1/de not_active IP Right Cessation
- 1991-08-24 DK DK91114221.4T patent/DK0473084T3/da active
- 1991-08-24 DE DE69114614T patent/DE69114614T2/de not_active Expired - Fee Related
- 1991-08-27 CA CA002050063A patent/CA2050063A1/en not_active Abandoned
-
1996
- 1996-01-09 GR GR960400028T patent/GR3018612T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04108827A (ja) | 1992-04-09 |
| DE69114614T2 (de) | 1996-03-28 |
| US5183660A (en) | 1993-02-02 |
| ES2079534T3 (es) | 1996-01-16 |
| DE69114614D1 (de) | 1995-12-21 |
| EP0473084A3 (en) | 1992-04-29 |
| EP0473084B1 (de) | 1995-11-15 |
| CA2050063A1 (en) | 1992-03-01 |
| GR3018612T3 (en) | 1996-04-30 |
| EP0473084A2 (de) | 1992-03-04 |
| JP3051145B2 (ja) | 2000-06-12 |
| DK0473084T3 (da) | 1996-03-04 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |