ES2080657A1 - Proteasas modificadas. - Google Patents

Proteasas modificadas.

Info

Publication number
ES2080657A1
ES2080657A1 ES09302039A ES9302039A ES2080657A1 ES 2080657 A1 ES2080657 A1 ES 2080657A1 ES 09302039 A ES09302039 A ES 09302039A ES 9302039 A ES9302039 A ES 9302039A ES 2080657 A1 ES2080657 A1 ES 2080657A1
Authority
ES
Spain
Prior art keywords
modified
serin
proteases
modified proteases
fibrinolitic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09302039A
Other languages
English (en)
Other versions
ES2080657B1 (es
Inventor
Keith Martyn Dawson
Richard James Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
BRITISCH BIO TECHNOLOGY LIMITE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRITISCH BIO TECHNOLOGY LIMITE filed Critical BRITISCH BIO TECHNOLOGY LIMITE
Priority to ES9302039A priority Critical patent/ES2080657B1/es
Publication of ES2080657A1 publication Critical patent/ES2080657A1/es
Application granted granted Critical
Publication of ES2080657B1 publication Critical patent/ES2080657B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SERIN PROTEASAS DE LA SUPERFAMILIA QUIMOTRIPSINA MODIFICADOS DE MANERA QUE MUESTRAN RESISTENCIA A LOS INHIBIDORES DE SERIN PROTEASAS. SI TALES SERIN PROTEASAS MODIFICADAS TIENE PROPIEDADES FIBRINOLITICAS, TROMBOLITICAS, ANTITROMBOTICAS O PROTROMBOTICAS, SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES O TRASTORNOS DE LA COAGULACION DE LA SANGRE.
ES9302039A 1993-09-27 1993-09-27 Proteasas modificadas. Expired - Fee Related ES2080657B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9302039A ES2080657B1 (es) 1993-09-27 1993-09-27 Proteasas modificadas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9302039A ES2080657B1 (es) 1993-09-27 1993-09-27 Proteasas modificadas.

Publications (2)

Publication Number Publication Date
ES2080657A1 true ES2080657A1 (es) 1996-02-01
ES2080657B1 ES2080657B1 (es) 1996-11-01

Family

ID=8283159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9302039A Expired - Fee Related ES2080657B1 (es) 1993-09-27 1993-09-27 Proteasas modificadas.

Country Status (1)

Country Link
ES (1) ES2080657B1 (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0381331A2 (en) * 1989-01-17 1990-08-08 Genzyme Corporation Gene sequences encoding modified residues situated in the protease domain of tpa
WO1990010649A1 (en) * 1989-03-06 1990-09-20 The Board Of Regents Of The University Of Texas System Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
WO1991009118A2 (en) * 1989-12-07 1991-06-27 British Bio-Technology Limited Activatable fibrinolytic and anti-thrombotic proteins
WO1992006203A1 (en) * 1990-09-28 1992-04-16 The Board Of Regents Of The University Of Texas System MUTANTS OF tPA WHICH ARE RESISTANT TO THEIR COGNATE SERPIN INHIBITOR

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0381331A2 (en) * 1989-01-17 1990-08-08 Genzyme Corporation Gene sequences encoding modified residues situated in the protease domain of tpa
WO1990010649A1 (en) * 1989-03-06 1990-09-20 The Board Of Regents Of The University Of Texas System Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
WO1991009118A2 (en) * 1989-12-07 1991-06-27 British Bio-Technology Limited Activatable fibrinolytic and anti-thrombotic proteins
WO1992006203A1 (en) * 1990-09-28 1992-04-16 The Board Of Regents Of The University Of Texas System MUTANTS OF tPA WHICH ARE RESISTANT TO THEIR COGNATE SERPIN INHIBITOR

Also Published As

Publication number Publication date
ES2080657B1 (es) 1996-11-01

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