ES2080891T3 - Preparacion de derivados de amina norbornil opticamente activos. - Google Patents

Preparacion de derivados de amina norbornil opticamente activos.

Info

Publication number
ES2080891T3
ES2080891T3 ES91302753T ES91302753T ES2080891T3 ES 2080891 T3 ES2080891 T3 ES 2080891T3 ES 91302753 T ES91302753 T ES 91302753T ES 91302753 T ES91302753 T ES 91302753T ES 2080891 T3 ES2080891 T3 ES 2080891T3
Authority
ES
Spain
Prior art keywords
preparation
optically active
norbornil
lower alkyl
amine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91302753T
Other languages
English (en)
Inventor
Mitsuaki Ohtani
Hisanori Takahashi
Fumihiko Watanabe
Masami Takayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2080891T3 publication Critical patent/ES2080891T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA PREPARAR UN COMPUESTO OPTICAMENTE ACTIVO UTIL COMO UN INTERMEDIARIO PARA LA PREPARACION DE UN ANTAGONISTA CLINICAMENTE IMPORTANTE RECEPTOR DE TROMBOXANA A SUB 2 (TXA SUB 2) MEDIANTE LA RESOLUCION DE UNA MEZCLA TACEMICA DE AMINO NORBORNILA DE LA FORMULA (I): DONDE R ELEVADO 1 ES HIDROGENO, ALQUILO BAJO O BAJO ALQUILO SUSTITUIDO CON -COOR ELEVADO 3 EN EL RESIDUO TERMINAL METILO; R ELEVADO 3 ES ALQUILO BAJO ; Y ES OXIGENO O METALENO; M Y N SON INDEPENDIENTEMENTE 0 O 1 CON UN ACIDO CIRALO.
ES91302753T 1990-03-30 1991-03-28 Preparacion de derivados de amina norbornil opticamente activos. Expired - Lifetime ES2080891T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2085443A JP2891740B2 (ja) 1990-03-30 1990-03-30 光学活性ノルボルナン系アミン誘導体の製造方法

Publications (1)

Publication Number Publication Date
ES2080891T3 true ES2080891T3 (es) 1996-02-16

Family

ID=13859017

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91302753T Expired - Lifetime ES2080891T3 (es) 1990-03-30 1991-03-28 Preparacion de derivados de amina norbornil opticamente activos.

Country Status (12)

Country Link
EP (1) EP0452000B1 (es)
JP (1) JP2891740B2 (es)
KR (1) KR0183988B1 (es)
AT (1) ATE129231T1 (es)
AU (1) AU632676B2 (es)
CA (1) CA2039401C (es)
DE (1) DE69113851T2 (es)
DK (1) DK0452000T3 (es)
ES (1) ES2080891T3 (es)
GR (1) GR3017815T3 (es)
HU (1) HU215926B (es)
TW (1) TW197412B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2055572A1 (en) * 1990-12-18 1992-06-19 David Kronenthal Processes and intermediates for thromboxane receptor antagonists
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
KR101299720B1 (ko) * 2006-08-16 2013-08-28 주식회사 엘지생명과학 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
CN110467539B (zh) * 2019-08-30 2023-01-06 浙江普洛家园药业有限公司 一种2，6-二甲基酪氨酸酯的拆分方法及其应用
CN117209433B (zh) * 2023-08-04 2026-02-10 南开大学 一种以降冰片胺为疏水基团的蛋白降解剂及其制备方法、药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH547771A (de) * 1970-07-17 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von bornanaminderivaten.
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0452000A2 (en) 1991-10-16
HU911056D0 (en) 1991-10-28
HU215926B (hu) 1999-03-29
CA2039401A1 (en) 1991-10-01
HUT60992A (en) 1992-11-30
JP2891740B2 (ja) 1999-05-17
AU632676B2 (en) 1993-01-07
EP0452000A3 (en) 1992-08-26
JPH03284657A (ja) 1991-12-16
DE69113851D1 (de) 1995-11-23
DE69113851T2 (de) 1996-05-15
ATE129231T1 (de) 1995-11-15
CA2039401C (en) 2003-02-25
EP0452000B1 (en) 1995-10-18
DK0452000T3 (da) 1995-11-27
KR0183988B1 (ko) 1999-05-15
GR3017815T3 (en) 1996-01-31
TW197412B (es) 1993-01-01
KR910016685A (ko) 1991-11-05
AU7384291A (en) 1991-10-03

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