ES2083103T3 - Procedimiento de una etapa para la produccion de diritromicina. - Google Patents
Procedimiento de una etapa para la produccion de diritromicina.Info
- Publication number
- ES2083103T3 ES2083103T3 ES92308839T ES92308839T ES2083103T3 ES 2083103 T3 ES2083103 T3 ES 2083103T3 ES 92308839 T ES92308839 T ES 92308839T ES 92308839 T ES92308839 T ES 92308839T ES 2083103 T3 ES2083103 T3 ES 2083103T3
- Authority
- ES
- Spain
- Prior art keywords
- diritromicina
- procedure
- stage
- production
- erythrocimiline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- WLOHNSSYAXHWNR-DWIOZXRMSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-DWIOZXRMSA-N 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 abstract 1
- 229960004100 dirithromycin Drugs 0.000 abstract 1
- 150000002373 hemiacetals Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA SINTESIS DE LA DIRITROMICINA ANTIBIOTICA EN FORMA CRISTALINA. EL PROCESO SE LLEVA A CABO MEDIANTE UN VASO DE REACCION SIMPLE MEDIANTE EL QUE UN ACETAL DISUELTO EN ACETONITRILO, EN PRESENCIA DE UN CATALIZADOR ACIDO, SE HIDROLIZA CON EL HEMIACETAL RELACIONADO QUE RELACIONA ENTONCES DIRECTAMENTE CON EL ERITROCIMILAMINO PARA FORMAR DIRITROMICINA CRISTALINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76880391A | 1991-09-30 | 1991-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2083103T3 true ES2083103T3 (es) | 1996-04-01 |
Family
ID=25083529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92308839T Expired - Lifetime ES2083103T3 (es) | 1991-09-30 | 1992-09-28 | Procedimiento de una etapa para la produccion de diritromicina. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5578713A (es) |
| EP (1) | EP0535900B1 (es) |
| JP (1) | JP3197957B2 (es) |
| KR (1) | KR100236246B1 (es) |
| CN (1) | CN1030455C (es) |
| AR (1) | AR248282A1 (es) |
| AT (1) | ATE133178T1 (es) |
| BR (1) | BR9203799A (es) |
| CA (1) | CA2079430A1 (es) |
| CZ (1) | CZ281664B6 (es) |
| DE (1) | DE69207696T2 (es) |
| DK (1) | DK0535900T3 (es) |
| ES (1) | ES2083103T3 (es) |
| FI (1) | FI104969B (es) |
| GR (1) | GR3018726T3 (es) |
| HK (1) | HK1006842A1 (es) |
| HU (1) | HU213620B (es) |
| IL (1) | IL103276A (es) |
| MX (1) | MX9205455A (es) |
| MY (1) | MY113261A (es) |
| NO (1) | NO178150C (es) |
| NZ (1) | NZ244495A (es) |
| PH (1) | PH30959A (es) |
| RU (1) | RU2045534C1 (es) |
| SK (1) | SK279270B6 (es) |
| TW (1) | TW287165B (es) |
| YU (1) | YU48748B (es) |
| ZA (1) | ZA927328B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA966601B (en) * | 1995-08-03 | 1997-02-19 | Chugai Pharmaceutical Co Ltd | Process for producing erythromycin derivatives. |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| EP1648415A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| CA2533292C (en) | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| EP1648418A4 (en) | 2003-07-21 | 2011-11-16 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| WO2005016311A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
| EP1658034A4 (en) * | 2003-08-29 | 2011-06-22 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
| WO2005027877A1 (en) | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8715727B2 (en) | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT342770B (de) * | 1975-04-07 | 1978-04-25 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer erythromycinderivate |
| US4438109A (en) * | 1980-07-25 | 1984-03-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Tylosin derivatives |
| JPS62103098A (ja) * | 1985-05-13 | 1987-05-13 | Microbial Chem Res Found | タイロシン誘導体 |
-
1992
- 1992-09-24 ZA ZA927328A patent/ZA927328B/xx unknown
- 1992-09-24 CZ CS922935A patent/CZ281664B6/cs not_active IP Right Cessation
- 1992-09-24 SK SK2935-92A patent/SK279270B6/sk unknown
- 1992-09-24 MY MYPI92001713A patent/MY113261A/en unknown
- 1992-09-24 IL IL103276A patent/IL103276A/xx not_active IP Right Cessation
- 1992-09-25 PH PH44995A patent/PH30959A/en unknown
- 1992-09-25 NZ NZ244495A patent/NZ244495A/en unknown
- 1992-09-25 MX MX9205455A patent/MX9205455A/es not_active IP Right Cessation
- 1992-09-28 ES ES92308839T patent/ES2083103T3/es not_active Expired - Lifetime
- 1992-09-28 NO NO923765A patent/NO178150C/no unknown
- 1992-09-28 KR KR1019920017679A patent/KR100236246B1/ko not_active Expired - Fee Related
- 1992-09-28 RU SU5052683/04A patent/RU2045534C1/ru not_active IP Right Cessation
- 1992-09-28 DE DE69207696T patent/DE69207696T2/de not_active Expired - Fee Related
- 1992-09-28 DK DK92308839.7T patent/DK0535900T3/da active
- 1992-09-28 EP EP92308839A patent/EP0535900B1/en not_active Expired - Lifetime
- 1992-09-28 AT AT92308839T patent/ATE133178T1/de not_active IP Right Cessation
- 1992-09-29 JP JP26002192A patent/JP3197957B2/ja not_active Expired - Fee Related
- 1992-09-29 CN CN92110845A patent/CN1030455C/zh not_active Expired - Fee Related
- 1992-09-29 AR AR92323301A patent/AR248282A1/es active
- 1992-09-29 BR BR929203799A patent/BR9203799A/pt not_active Application Discontinuation
- 1992-09-29 YU YU87792A patent/YU48748B/sh unknown
- 1992-09-29 CA CA002079430A patent/CA2079430A1/en not_active Abandoned
- 1992-09-29 HU HU9203101A patent/HU213620B/hu not_active IP Right Cessation
- 1992-09-29 FI FI924360A patent/FI104969B/fi active
- 1992-10-27 TW TW081108536A patent/TW287165B/zh active
-
1993
- 1993-07-20 US US08/095,366 patent/US5578713A/en not_active Expired - Fee Related
-
1996
- 1996-01-18 GR GR960400113T patent/GR3018726T3/el unknown
-
1998
- 1998-06-22 HK HK98105921A patent/HK1006842A1/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR248282A1 (es) | Un procedimiento para la preparacion dediritromicina cristalina. | |
| MX9303294A (es) | Proceso para la produccion de acido acetico. | |
| ES8206531A1 (es) | Metodo para producir un 1,1-dioxopenicilanoiloximetil 6- (d-a-amino-a-fenilacetamido)penicilanato tosilato hidrato cristalino | |
| IT1272109B (it) | Processo per la preparazione di apg | |
| ES2120973T3 (es) | Sal de diastereomero de acido quinolinmevalonico opticamente activo. | |
| ES2147798T3 (es) | Un procedimiento para la produccion de compuestos de tetrazolilo. | |
| ES2104288T3 (es) | Procedimiento para la produccion de esteres del acido metacrilico. | |
| MY117968A (en) | Process for the production of an aqueous monoester peroxycarboxylic acid solution, the solution obtainable by this process, and its use as disinfectant | |
| ES2074821T3 (es) | Sintesis de eter alquil terc.-alquilico usando catalizadores de zeolita. | |
| ES2115678T3 (es) | Proceso para producir ester halometilico de acido carboxilico alifatico. | |
| ES8305770A1 (es) | Un procedimiento para la preparacion de bis-esteres de metanodiol. | |
| ES2105217T3 (es) | Preparacion de intermedios en la sintesis de antibioticos de quinolina. | |
| MX9307292A (es) | Sintesis regioselectiva de acido 4-cloro-2-tiofenocarboxilico. | |
| BR0214781A (pt) | Processo para a preparação de metionina | |
| ES2055238T3 (es) | Procedimiento para producir esteres de acido alfa-ceto-carboxilico. | |
| ES2195364T3 (es) | Procedimiento de eterificacion de un alcohol de tipo bencilico, productos obtenidos y sus aplicaciones. | |
| ES2058622T3 (es) | Esteres substituidos del acido acrilico. | |
| FI862557A0 (fi) | Foerfarande foer framstaellning av en dibromnitrofoerening. | |
| EP0147472A4 (en) | 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one. | |
| AR245728A1 (es) | Un procedimiento para la produccion del antibiotico uk 61689 o una sal farmaceuticamente aceptable del mismo. | |
| ES2181899T3 (es) | Procedimiento para la produccion de acido azetidin-2-carboxilico enantiomericamente puro. | |
| MX9304140A (es) | Sal de purina, proceso para su preparacion y proceso para preparar un agente antiviral mediante la reaccion de dicha sal. | |
| ES2089654T3 (es) | Procedimiento para purificar amidas de acidos grasos. | |
| ES554671A0 (es) | Procedimiento para la fabricacion de acidos 6-alcoxi (inferior)-5-halo-1-naftoicos y sus esteres correspondientes | |
| IT7827076A0 (it) | Processo per la produzione di acido 2-ammino-2-fenilacetico eventualmente sostituito, otticamente attivo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 535900 Country of ref document: ES |