ES2083291T3 - Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas. - Google Patents

Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas.

Info

Publication number
ES2083291T3
ES2083291T3 ES93913148T ES93913148T ES2083291T3 ES 2083291 T3 ES2083291 T3 ES 2083291T3 ES 93913148 T ES93913148 T ES 93913148T ES 93913148 T ES93913148 T ES 93913148T ES 2083291 T3 ES2083291 T3 ES 2083291T3
Authority
ES
Spain
Prior art keywords
nanovesicular
preparation
cyclodextrin
nanocapsules
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913148T
Other languages
English (en)
Inventor
Mohamed Skiba
Denis Wouessidjewe
Hatem Fessi
Jean-Philippe Devissaguet
Dominique Duchene
Francis Puisieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Application granted granted Critical
Publication of ES2083291T3 publication Critical patent/ES2083291T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

LA PREPARACION DEL SISTEMA NANOVESICULAR SE CARACTERIZA, SEGUN EL INVENTO, PORQUE: (1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA BASICAMENTE POR UNA SOLUCION DE CICLODEXTRINA MODIFICADA POR GRUPOS ACILO Y DE UN ACEITE EN UN DISOLVENTE O MEZCLA DE DISOLVENTES ORGANICOS(S); (2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA BASICAMENTE DE AGUA O MEZCLA ACUOSA, PUDIENDO CONTENER UNO O VARIOS AGENTES TENSOACTIVOS, PUDIENDO A UNA DE LAS FASES (1) Y (2) AÑADIR UNA MOLECULA ACTIVA; (3) SE AÑADE BAJO AGITACION MODERADA UNA DE LAS FASES LIQUIDAS OBTENIDAS POR (1) O (2) A LA OTRA, DE MODO QUE SE OBTENGA PRACTICAMENTE AL INSTANTE UNA SUSPENSION COLOIDAL DE NANOCAPSULAS DE CICLODEXTRINA MODIFICADA QUE CONTIENE ACEITE Y EVENTUALMENTE LA MOLECULA ACTIVA. EN CASO CONTRARIO, SE ELIMINA TODO O PARTE DEL DISOLVENTE O MEZCLA DE DISOLVENTES Y DEL AGUA O MEZCLA ACUOSA. SE APLICA A LOS VECTORES DE PRODUCTOS FARMACEUTICOS, COSMETICOS, QUIMICOS, ETC.
ES93913148T 1992-06-16 1993-06-16 Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas. Expired - Lifetime ES2083291T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929207285A FR2692167B1 (fr) 1992-06-16 1992-06-16 Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.

Publications (1)

Publication Number Publication Date
ES2083291T3 true ES2083291T3 (es) 1996-04-01

Family

ID=9430799

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913148T Expired - Lifetime ES2083291T3 (es) 1992-06-16 1993-06-16 Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas.

Country Status (7)

Country Link
EP (1) EP0646002B1 (es)
JP (1) JPH07507783A (es)
AT (1) ATE132037T1 (es)
DE (1) DE69301150T2 (es)
ES (1) ES2083291T3 (es)
FR (1) FR2692167B1 (es)
WO (1) WO1993025194A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296472A (en) * 1991-12-05 1994-03-22 Vyrex Corporation Methods for delipidation of skin and cerumen removal
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
FR2808691B1 (fr) 2000-05-12 2005-06-24 Coletica Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine
DE60133550T2 (de) 2001-09-17 2009-04-02 Nanopart-C S.A. Neue dispergierbare kolloidale Calixarene-Systeme in Form von Nanoteilchen
EP2283864A1 (en) * 2002-07-16 2011-02-16 Elan Pharma International Ltd. Liquid dosage compositions fo stable nanoparticulate active agents
FR2903987B1 (fr) * 2006-07-21 2012-12-21 Centre Nat Rech Scient Nouveaux derives de cyclodextrines amphiphiles, leur utilisation dans les domaines pharmaceutiques,cosmetiques, alimentaires et leur application a la production de nouveaux nanosystemes
CN113089333B (zh) * 2021-03-31 2022-11-08 上海应用技术大学 一种基于氯丙醇-β-环糊精的双包埋囊泡及其制备方法
CN116327734A (zh) * 2023-04-11 2023-06-27 杭州师范大学 一种基于手性螺旋分子的纳米胶囊及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2660193B1 (fr) * 1990-04-03 1994-11-04 Philippe Maincent Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules.

Also Published As

Publication number Publication date
JPH07507783A (ja) 1995-08-31
EP0646002A1 (fr) 1995-04-05
ATE132037T1 (de) 1996-01-15
WO1993025194A1 (fr) 1993-12-23
FR2692167A1 (fr) 1993-12-17
FR2692167B1 (fr) 1994-09-16
DE69301150D1 (de) 1996-02-08
DE69301150T2 (de) 1996-09-05
EP0646002B1 (fr) 1995-12-27

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