ES2083363T3 - Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos. - Google Patents

Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos.

Info

Publication number
ES2083363T3
ES2083363T3 ES88309697T ES88309697T ES2083363T3 ES 2083363 T3 ES2083363 T3 ES 2083363T3 ES 88309697 T ES88309697 T ES 88309697T ES 88309697 T ES88309697 T ES 88309697T ES 2083363 T3 ES2083363 T3 ES 2083363T3
Authority
ES
Spain
Prior art keywords
nucleic acid
multimers
oligonucleotide
hybridization tests
acid hybridization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309697T
Other languages
English (en)
Inventor
Michael S Urdea
Brian Warner
Joyce A Running
Janice A Kolberg
Jennifer M Clyne
Ray Sanchez-Pescador
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ES2083363T3 publication Critical patent/ES2083363T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
    • G01N2333/04—Varicella-zoster virus
    • G01N2333/045—Cytomegalovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

MULTIMEROS DE OLIGONUCLEOTIDOS LINEALES O RAMIFICADOS UTILES COMO AMPLIFICADORES EN ENSAYOS BIOQUIMICOS QUE COMPRENDEN (1) AL MENOS UNA UNIDAD DE OLIGONUCLEOTIDO DE CORDON UNICO QUE ES COMPLEMENTARIA DE UNA SECUENCIA DE OLIGONUCLEOTIDO DE UNICO CORDON DE INTERES, Y (2) UNA MULTIPLICIDAD DE UNIDADES DE CORDON UNICO QUE SON COMPLEMENTARIAS DE UN OLIGONUCLEOTIDO MARCADO DE CORDON UNICO. SE MUESTRAN EJEMPLOS DE HIBRIDACION DE ACIDO NUCLEICO DE ESTRUCTURA SANDURIDA AMPLIFICADA E INMUNOENSAYOS QUE UTILIZAN LOS MULTINUMEROS.
ES88309697T 1987-10-15 1988-10-17 Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos. Expired - Lifetime ES2083363T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10928287A 1987-10-15 1987-10-15
US18520188A 1988-04-22 1988-04-22
US25263888A 1988-09-30 1988-09-30

Publications (1)

Publication Number Publication Date
ES2083363T3 true ES2083363T3 (es) 1996-04-16

Family

ID=27380635

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309697T Expired - Lifetime ES2083363T3 (es) 1987-10-15 1988-10-17 Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos.

Country Status (9)

Country Link
EP (1) EP0317077B1 (es)
AT (1) ATE133713T1 (es)
CA (1) CA1339351C (es)
DE (1) DE3854956T2 (es)
DK (1) DK175932B1 (es)
ES (1) ES2083363T3 (es)
GR (1) GR3019046T3 (es)
IE (1) IE75211B1 (es)
WO (1) WO1989003891A1 (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430136A (en) * 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5047523A (en) * 1988-08-02 1991-09-10 Ortho Diagnostic Systems Inc. Nucleic acid probe for detection of neisseria gonorrhoea
JP3068848B2 (ja) * 1988-12-09 2000-07-24 アムラド・コーポレイション・リミテッド 増幅ｄｎａ検定
DE3925613A1 (de) * 1989-06-22 1991-01-03 Boehringer Mannheim Gmbh Neisseria-spezifische dna-sonde
WO1991004262A1 (en) 1989-09-15 1991-04-04 National Institute Of Health Of Japan New hcv isolates
US5232829A (en) * 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
CA2025179A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting cryptococcus neoformans
CA2025180A1 (en) * 1989-10-12 1991-04-13 William G. Weisburg Nucleic acid probes and methods for detecting pathogenic candida yeasts
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
IE910081A1 (en) 1990-01-10 1991-07-17 Chiron Corp The use of DNA-dependent RNA polymerase transcripts as¹reporter molecules for signal amplification in nucleic acid¹hybridization assays
CA2037349C (en) * 1990-03-26 2008-06-17 James G. Wetmur Branch migration of nucleotides
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
IE911534A1 (en) * 1990-05-04 1991-11-06 Chiron Corp Protein-nucleic acid probes and immunoassays using same
US5430138A (en) * 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
AU8412991A (en) * 1990-07-27 1992-03-02 Chiron Corporation Large comb-type branched polynucleotides
US5849481A (en) * 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5420330A (en) * 1990-09-07 1995-05-30 Pharmacia P-L Biochemicals Inc. Lipo-phosphoramidites
JPH06509707A (ja) * 1991-06-17 1994-11-02 カイロン　コーポレイション 選択可能な開裂部位を用いるポリヌクレオチド確認法
CA2124797C (en) * 1991-12-23 2004-03-30 Bruce D. Irvine Hiv probes for use in solution phase sandwich hybridization assays
JPH07502658A (ja) * 1991-12-23 1995-03-23 バイエル　コーポレイション 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのｈａｖプローブ
EP0625214A4 (en) * 1991-12-23 1997-07-16 Chiron Corp Cmv probes for use in solution phase sandwich hybridization assays.
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
WO1993013225A1 (en) * 1991-12-23 1993-07-08 Chiron Corporation Htlv-1 probes for use in solution phase sandwich hybridization assays
EP0618924B1 (en) * 1991-12-23 2001-02-14 Bayer Corporation Hbv amplifier probes for use in solution phase sandwich hybridization assays
EP0726963A4 (en) * 1991-12-23 1998-05-13 Chiron Corp PROBES FOR -i (CHLAMYDIAE) FOR USE IN SOLUTION PHASE SANDWICH HYBRIDIZATION METHODS
AU4596893A (en) * 1992-05-29 1993-12-30 Gen Trak, Inc. Signal amplification probe and methods of use
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
BE1007918A3 (fr) * 1993-02-19 1995-11-21 Wallone Region Sondes d'acides nucleiques chimiquement modifiees en 5'(oh) et/ou en 3'(oh) en vue de l'introduction en ces positions d'un ou plusieurs elements de marquage non radioactif et procede de preparation.
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
US5561043A (en) * 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5648213A (en) * 1994-08-30 1997-07-15 Beckman Instruments, Inc. Compositions and methods for use in detection of analytes
US5853974A (en) 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
US5780227A (en) * 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
US6632936B2 (en) 1995-09-06 2003-10-14 Icos Corp Cell-cycle checkpoint genes
CA2218440A1 (en) * 1996-12-21 1998-06-21 Boehringer Mannheim Gmbh Method of analysis using signal amplification
EP1025220B1 (en) 1997-10-21 2007-01-03 The University Court Of The University Of Glasgow JMY, A CO-ACTIVATOR FOR p300/CBP, NUCLEIC ACID ENCODING JMY AND USES THEREOF
US5962273A (en) * 1997-11-04 1999-10-05 Becton Dickinson And Company Detection of Neisseria gonorrhoeae by amplification and detection of its nucleic acid
GB9806093D0 (en) 1998-03-20 1998-05-20 Taylor John Hermon Diagnostics and vaccines for mycobacterial infections of animals and humans
US5976805A (en) * 1998-04-27 1999-11-02 Becton Dickinson And Company Neisseria gonorrhoeae specific DNA fragment--GC3
US6468743B1 (en) * 1998-05-18 2002-10-22 Conagra Grocery Products Company PCR techniques for detecting microbial contaminants in foodstuffs
GB9811403D0 (en) * 1998-05-27 1998-07-22 Isis Innovation Polynucleotide multimers and their use in hybridisation assays
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
GB9914943D0 (en) * 1999-06-25 1999-08-25 Imp College Innovations Ltd Methods
US20030211496A1 (en) * 2000-03-29 2003-11-13 Getts Robert C Quality control reagents for nucleic acid microarrays
US7763421B2 (en) 2000-06-05 2010-07-27 Ventana Medical Systems, Inc. Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation
US20040106120A1 (en) 2000-11-30 2004-06-03 Rachid Tazi-Ahnini Diagnosis and treatment of disease
WO2004058159A2 (en) 2002-12-23 2004-07-15 Dynavax Technologies Corporation Branched immunomodulatory compounds and methods of using the same
US7229800B2 (en) 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
CN101490275A (zh) * 2006-04-07 2009-07-22 西门子医疗保健诊断公司 淋病奈瑟氏球菌特异性寡核苷酸序列
JP2008043332A (ja) * 2006-08-17 2008-02-28 Panomics Inc 組織スライドからの核酸定量
SG157299A1 (en) 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
WO2009151407A2 (en) 2008-06-14 2009-12-17 Veredus Laboratories Pte Ltd Influenza sequences
WO2010071610A1 (en) 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
SG11202107720UA (en) 2019-01-31 2021-08-30 Agency Science Tech & Res Cnx/erp57 inhibitor for use in the treatment or prevention of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
DE3420925A1 (de) * 1984-06-05 1985-12-05 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagenz zum nachweis einer nukleinsaeure-sequenz
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
CA1272443A (en) * 1985-02-22 1990-08-07 Nanibhushan Dattagupta Solution-phase dual hybridization assay for detecting polynucleotide sequences
US5252760A (en) 1985-03-28 1993-10-12 Chiron Corporation Method of using colored phosphorylating reagents
EP0204510B1 (en) * 1985-05-31 1991-07-10 Amoco Corporation Amplification of hybridization signals by employing complementary dna strands
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
EP0238332A2 (en) * 1986-03-19 1987-09-23 Cetus Corporation Liquid hybridization method and kit for detecting the presence of nucleic acid sequences in samples

Also Published As

Publication number Publication date
EP0317077A1 (en) 1989-05-14
DK175932B1 (da) 2005-07-18
ATE133713T1 (de) 1996-02-15
DE3854956D1 (de) 1996-03-14
DE3854956T2 (de) 1996-06-13
DK294589A (da) 1989-08-15
EP0317077B1 (en) 1996-01-31
WO1989003891A1 (en) 1989-05-05
DK294589D0 (da) 1989-06-15
CA1339351C (en) 1997-08-26
GR3019046T3 (en) 1996-05-31
IE883131L (en) 1989-04-15
IE75211B1 (en) 1997-08-27

Similar Documents

Publication Publication Date Title
ES2083363T3 (es) Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos.
DE69027211D1 (de) Verbesserte nukleinsäure-hybridisierungstests für hbv, die amplifikation verwenden
DE69233630D1 (de) Sätze von HIV Sonden für Solution Sandwich Hybridationsverfahren
DK0567635T3 (da) Hurtige assays for amplifikationsprodukter
ATE115959T1 (de) Markiertes dna.
DK0389063T4 (da) Fremgangsmåde til isolering af nukleinsyre
FI880131A7 (fi) T7-dna-polymeras.
DE3767270D1 (de) Urethangruppen enthaltende (meth)-acrylsaeurederivate.
FI873495L (fi) Foerstaerkt hybridiseringsanalys.
DE3578190D1 (de) Test fuer nukleinsaeuresequenzen, insbesondere genetische veraenderungen.
ATE174926T1 (de) Hydrophobe nukleinsäure-sonde
DK0587331T3 (da) Nukleinsyreprober til Chlamydia pneumoniae.
DK0572120T3 (da) Nucleinsyre-probertil mycobacterium tuberculosis
FI882800A7 (fi) Parannettu nukleiinihappohybridisaatiotekniikka ja testipakkaus.
FI870946A7 (fi) Nopea DNA-testi mikrobien toteamiseksi.
DE3765765D1 (de) Polymere als beizmittel fuer saure farbstoffe.
ATE45385T1 (de) Polynucleotid-hybridisierungsprobe.
FI880412A0 (fi) Biologisk respons modifierande aemne.
ATE78598T1 (de) Immunassay unter benutzung der mikropartikelneutralisierung.
NO301890B1 (no) Fremgangsmåte for forsterkning av minst en spesifikk nukleinsyre-sekvens samt anvendelse av fremgangsmåten
ATE80667T1 (de) T7-dns-polymerase.
ATE104343T1 (de) T7-dns-polymerase.
KR940012633U (ko) 핵산(dna) 증폭 배양기
NO913791L (no) Fremgangsmaate for nukleinsyrepaavisning ved binaer amplifikasjon.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 317077

Country of ref document: ES