ATE115959T1 - Markiertes dna. - Google Patents
Markiertes dna.Info
- Publication number
- ATE115959T1 ATE115959T1 AT84305989T AT84305989T ATE115959T1 AT E115959 T1 ATE115959 T1 AT E115959T1 AT 84305989 T AT84305989 T AT 84305989T AT 84305989 T AT84305989 T AT 84305989T AT E115959 T1 ATE115959 T1 AT E115959T1
- Authority
- AT
- Austria
- Prior art keywords
- labels
- dna molecule
- bonded
- dna
- marked dna
- Prior art date
Links
- 108020004414 DNA Proteins 0.000 abstract 4
- 102000053602 DNA Human genes 0.000 abstract 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 108020004682 Single-Stranded DNA Proteins 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/529,044 US4626501A (en) | 1983-09-02 | 1983-09-02 | Labeled DNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115959T1 true ATE115959T1 (de) | 1995-01-15 |
Family
ID=24108275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84305989T ATE115959T1 (de) | 1983-09-02 | 1984-08-31 | Markiertes dna. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4626501A (de) |
| EP (1) | EP0138357B1 (de) |
| JP (1) | JPS60172994A (de) |
| AT (1) | ATE115959T1 (de) |
| CA (1) | CA1234061A (de) |
| DE (1) | DE3486362T2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200313A (en) * | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
| US5002885A (en) * | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
| US4952685A (en) * | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US4957858A (en) * | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
| DE3431536A1 (de) * | 1984-08-28 | 1986-03-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren |
| US4828979A (en) * | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
| US4824775A (en) * | 1985-01-03 | 1989-04-25 | Molecular Diagnostics, Inc. | Cells labeled with multiple Fluorophores bound to a nucleic acid carrier |
| ATE40572T1 (de) * | 1985-01-10 | 1989-02-15 | Molecular Diagnostics Inc | Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben. |
| US5026840A (en) * | 1985-01-10 | 1991-06-25 | Molecular Diagnostics, Inc. | Photochemical nucleic acid-labeling reagent having a polyalklamine spacer |
| EP0195320B1 (de) * | 1985-03-19 | 1991-06-12 | Abbott Laboratories | Diagnostische Probe, die Mikroperoxidase verwendet |
| GB8509880D0 (en) * | 1985-04-17 | 1985-05-22 | Ici Plc | Testing device |
| DE3689223T2 (de) * | 1985-05-15 | 1994-03-03 | Amoco Corp | Cytidinanaloga. |
| EP0204510B1 (de) * | 1985-05-31 | 1991-07-10 | Amoco Corporation | Verstärkung von Hybridisierungssignalen durch Verwendung von komplementarischen DNS-Strängen |
| US4833251A (en) * | 1985-06-25 | 1989-05-23 | Siska Diagnostics, Inc. | Compounds for tagging nucleic acid probes |
| US5093232A (en) * | 1985-12-11 | 1992-03-03 | Chiron Corporation | Nucleic acid probes |
| US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
| ATE88761T1 (de) * | 1986-01-10 | 1993-05-15 | Amoco Corp | Kompetitiver homogener test. |
| US4925785A (en) * | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
| GB8621337D0 (en) * | 1986-09-04 | 1986-10-15 | Agricultural Genetics Co | Non-radioactive nucleic acid hybridization probes |
| US5428163A (en) * | 1986-12-31 | 1995-06-27 | Mills; Randell L. | Prodrugs for selective drug delivery |
| IL86164A0 (en) * | 1987-04-28 | 1988-11-15 | Tamir Biotechnology Ltd | Improved dna probes |
| FR2618160B1 (fr) * | 1987-07-16 | 1990-03-09 | Ire Celltarg Sa | Technique enzymatique utilisant un chromogene lyophilise, trousse de reactif et procede de lyophilisation |
| FR2620122B1 (fr) * | 1987-09-03 | 1989-12-29 | Pasteur Institut | Procede d'obtention par voie chimique d'oligonucleotides marques et applications biologiques |
| JPH0630574B2 (ja) * | 1987-10-02 | 1994-04-27 | シタス コーポレイション | オリゴヌクレオチド‐西洋ワサビパーオキシダーゼ共有結合接合体 |
| US4962029A (en) * | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US5656731A (en) * | 1987-10-15 | 1997-08-12 | Chiron Corporation | Nucleic acid-amplified immunoassay probes |
| CA1341077C (en) * | 1988-03-31 | 2000-08-08 | Randell L. Mills | Luminide and macroluminide class of pharmaceuticals |
| US6326136B1 (en) | 1988-04-01 | 2001-12-04 | Digene Corporation | Macromolecular conjugate made using unsaturated aldehydes |
| US5109124A (en) * | 1988-06-01 | 1992-04-28 | Biogen, Inc. | Nucleic acid probe linked to a label having a terminal cysteine |
| FR2644163B2 (fr) * | 1988-07-13 | 1994-09-30 | Bioprobe Systems Sa | Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede |
| FR2634211B1 (fr) * | 1988-07-13 | 1992-06-26 | Lebacq Philippe | Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede |
| US5858652A (en) * | 1988-08-30 | 1999-01-12 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
| US5082935A (en) * | 1988-12-15 | 1992-01-21 | Amoco Corporation | Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination |
| US5049489A (en) * | 1989-04-17 | 1991-09-17 | The Standard Oil Company | 16S rRNA oligonucleotide probes for the identification of sulfate-reducing bacteria |
| WO1991002040A1 (en) * | 1989-08-04 | 1991-02-21 | Kosak Kenneth M | Cyclodextrin labels for nucleic acid and biochemical analysis |
| GB8927503D0 (en) * | 1989-12-04 | 1990-02-07 | Kronem Systems Inc | Enzyme-amplified lanthanide chelate luminescence |
| AU8412991A (en) * | 1990-07-27 | 1992-03-02 | Chiron Corporation | Large comb-type branched polynucleotides |
| US5849481A (en) * | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5512433A (en) * | 1990-11-08 | 1996-04-30 | Vysis, Inc. | Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes |
| US5258507A (en) * | 1990-11-08 | 1993-11-02 | Amoco Corporation | Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes |
| ZA936015B (en) * | 1992-08-24 | 1994-03-10 | Akzo Nv | Elimination of false negatives in nuleic acid detection. |
| JP3612534B2 (ja) * | 1998-09-04 | 2005-01-19 | 独立行政法人理化学研究所 | Ｄｎａ固定支持方法およびｄｎａ固定支持体 |
| AU2001266861A1 (en) * | 2000-06-12 | 2001-12-24 | Randell L. Mills | Photocleavable prodrugs for selective drug delivery |
| GB0029154D0 (en) | 2000-11-30 | 2001-01-17 | Lee Helen | Signal enhancement with multiple labelled-antibodies |
| US7361310B1 (en) | 2001-11-30 | 2008-04-22 | Northwestern University | Direct write nanolithographic deposition of nucleic acids from nanoscopic tips |
| US20050080260A1 (en) * | 2003-04-22 | 2005-04-14 | Mills Randell L. | Preparation of prodrugs for selective drug delivery |
| EP2170501A2 (de) * | 2007-06-20 | 2010-04-07 | Northwestern University | Universelle matrix |
| EP2185975A1 (de) * | 2007-08-08 | 2010-05-19 | Northwestern University | Unabhängig adressierbare selbstkorrigierende betintung für kragträgerarrays |
| KR101935146B1 (ko) * | 2017-04-26 | 2019-01-03 | 아주대학교산학협력단 | 재귀반사 현상을 이용한 분자 비콘 기반의 광학 유전자 바이오센서 및 이를 이용한 핵산 분자의 정량 분석 방법 |
| GB201912866D0 (en) * | 2019-09-06 | 2019-10-23 | Cambridge Molecular Diagnostics Ltd | Miltiply labelled polymetric molecule for detection assays |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139346A (en) * | 1977-11-28 | 1979-02-13 | Enzo Bio Chem Incorporated | Nucleic acid and protein binding paper |
| FR2422956A1 (fr) * | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| US4228237A (en) * | 1978-09-21 | 1980-10-14 | Calbiochem-Behring Corp. | Methods for the detection and determination of ligands |
| US4286964A (en) * | 1979-10-12 | 1981-09-01 | Seed Brian S | Polyfunctional epoxides and halohydrins used as bridging groups to bind aromatic amine group-containing alcohols and thiols to hydroxyl bearing substrates |
| US4282287A (en) * | 1980-01-24 | 1981-08-04 | Giese Roger W | Biochemical avidin-biotin multiple-layer system |
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| FR2519005B1 (fr) * | 1981-12-29 | 1985-10-25 | Pasteur Institut | Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn |
-
1983
- 1983-09-02 US US06/529,044 patent/US4626501A/en not_active Expired - Fee Related
-
1984
- 1984-08-31 EP EP84305989A patent/EP0138357B1/de not_active Expired - Lifetime
- 1984-08-31 CA CA000462205A patent/CA1234061A/en not_active Expired
- 1984-08-31 DE DE3486362T patent/DE3486362T2/de not_active Expired - Fee Related
- 1984-08-31 AT AT84305989T patent/ATE115959T1/de not_active IP Right Cessation
- 1984-09-03 JP JP59184354A patent/JPS60172994A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1234061A (en) | 1988-03-15 |
| EP0138357A3 (en) | 1986-05-07 |
| DE3486362T2 (de) | 1995-05-11 |
| EP0138357B1 (de) | 1994-12-21 |
| JPS60172994A (ja) | 1985-09-06 |
| US4626501A (en) | 1986-12-02 |
| DE3486362D1 (de) | 1995-02-02 |
| EP0138357A2 (de) | 1985-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |