ES2084725T3 - Nuevos derivados de ciclobutano. - Google Patents

Nuevos derivados de ciclobutano.

Info

Publication number
ES2084725T3
ES2084725T3 ES91108303T ES91108303T ES2084725T3 ES 2084725 T3 ES2084725 T3 ES 2084725T3 ES 91108303 T ES91108303 T ES 91108303T ES 91108303 T ES91108303 T ES 91108303T ES 2084725 T3 ES2084725 T3 ES 2084725T3
Authority
ES
Spain
Prior art keywords
group
compounds
cyclobutane derivatives
formula
new cyclobutane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91108303T
Other languages
English (en)
Inventor
Yuh-Ichiro Ichikawa
Hiroshi Akaba
Yuka Sugawara
Hideo Sugimura
Kazuhisa Narita
Akira Shiozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Application granted granted Critical
Publication of ES2084725T3 publication Critical patent/ES2084725T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE CICLOBUTANO REPRESENTADOS POR LA SIGUIENTE FORMULA GENERAL (1) Y SALES FISIOLOGICAMENTE ACEPTABLES DE LOS MISMOS: EN DONDE B REPRESENTA UN DERIVADO BASICO DE ACIDO NUCLEICO, R ELEVADO 1 Y R (AL CUADRADO) INDEPENDIENTEMENTE REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO DE DIALQUILAMINOACILO, UN GRUPO DE 1,4-DIHIDRO-1-METILNICOTINOILO O UN GRUPO DE ACIDO FOSFORICO SUSTITUIDO, SIEMPRE Y CUANDO BIEN R ELEVADO 1 O R (AL CUADRADO) SEA UN GRUPO DISTINTO DE UN ATOMO DE HIDROGENO. LOS COMPUESTOS DE LA INVENCION PRESENTAN UNA ALTA ABSORBENCIA ORAL Y SON METABOLIZADOS EN VIVO EN LOS COMPUESTOS DE LA FORMULA (1A). SEGUN ESTO, SE ESPERA QUE LOS COMPUESTOS DE LA INVENCION SEAN UTILES COMO AGENTES ANTIVIRICOS.
ES91108303T 1990-05-24 1991-05-23 Nuevos derivados de ciclobutano. Expired - Lifetime ES2084725T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13268690 1990-05-24

Publications (1)

Publication Number Publication Date
ES2084725T3 true ES2084725T3 (es) 1996-05-16

Family

ID=15087157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91108303T Expired - Lifetime ES2084725T3 (es) 1990-05-24 1991-05-23 Nuevos derivados de ciclobutano.

Country Status (7)

Country Link
US (1) US5324730A (es)
EP (1) EP0458312B1 (es)
KR (1) KR0159945B1 (es)
AU (1) AU642738B2 (es)
CA (1) CA2043099A1 (es)
DE (1) DE69118016T2 (es)
ES (1) ES2084725T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2042931A1 (en) * 1990-05-24 1991-11-25 Robert Zahler Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines
CA2052315A1 (en) * 1990-10-09 1992-04-10 Masashi Nagai Cyclobutane derivatives
MX2007006961A (es) * 2004-12-10 2007-10-04 Univ Emory Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal.
CN102227427B (zh) * 2008-11-27 2014-04-02 国立大学法人香川大学 环丁基嘌呤衍生物、血管新生促进剂、管腔形成促进剂、神经细胞生长促进剂及药品
TW202019941A (zh) 2018-07-27 2020-06-01 日商富士軟片股份有限公司 環丁基嘌呤衍生物或其鹽
US10910081B2 (en) 2018-12-17 2021-02-02 Micron Technology, Inc. Management of test resources to perform reliability testing of memory components

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
JPS62208295A (ja) * 1986-03-07 1987-09-12 Nippon Kayaku Co Ltd ヒポキサンチン塩基を有する新規化合物およびその製造法
JPS63264527A (ja) * 1987-04-21 1988-11-01 Nippon Kayaku Co Ltd 抗エイズウイルス剤
IL86381A0 (en) * 1987-05-19 1988-11-15 Nippon Kayaku Kk Oxetanocins and pharmaceutical compositions containing the same
US4855466A (en) * 1987-12-28 1989-08-08 E. R. Squibb & Sons, Inc. Purinyl cyclobutanes
US5041447A (en) * 1988-03-23 1991-08-20 Nippon Kayaku Kabushiki Kaisha Oxetanocin-related compounds and pharmaceutical compositions containing them
US5723609A (en) * 1988-03-30 1998-03-03 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl purines
AU622926B2 (en) * 1988-09-09 1992-04-30 Nippon Kayaku Kabushiki Kaisha Pyrimidine or purine cyclobutane derivatives
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
EP0427799B1 (en) * 1989-01-24 1994-11-30 Gensia, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
US4992368A (en) * 1989-04-20 1991-02-12 Nippon Kayaku Kabushiki Kaisha Novel process for producing oxetanocin G
US4960910A (en) * 1989-06-13 1990-10-02 Nippon Kayaku Kabushiki Kaisha Oxetane derivatives
JPH03173896A (ja) * 1989-09-08 1991-07-29 Nippon Kayaku Co Ltd 新規オキセタノシン誘導体、その塩およびその用途

Also Published As

Publication number Publication date
DE69118016D1 (de) 1996-04-25
CA2043099A1 (en) 1991-11-25
KR910020021A (ko) 1991-12-19
KR0159945B1 (ko) 1999-01-15
AU642738B2 (en) 1993-10-28
DE69118016T2 (de) 1996-08-01
EP0458312A1 (en) 1991-11-27
US5324730A (en) 1994-06-28
EP0458312B1 (en) 1996-03-20
AU7731291A (en) 1991-11-28

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