ES2086046T3 - Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii. - Google Patents

Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii.

Info

Publication number
ES2086046T3
ES2086046T3 ES92118597T ES92118597T ES2086046T3 ES 2086046 T3 ES2086046 T3 ES 2086046T3 ES 92118597 T ES92118597 T ES 92118597T ES 92118597 T ES92118597 T ES 92118597T ES 2086046 T3 ES2086046 T3 ES 2086046T3
Authority
ES
Spain
Prior art keywords
substituted
biphenyl
piridones
angiotensin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92118597T
Other languages
English (en)
Inventor
Matthias Dr Muller-Gliemann
Martin Dr Beuck
Stanislav Prof Dr Kazda
Johannes-Peter Dr Stasch
Andreas Dr Knorr
Stefan Dr Wohlfeil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2086046T3 publication Critical patent/ES2086046T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

BIFENIL PIRIDONA SUSTITUIDA DE LA FORMULA GENERAL EN DONDE R1, R2, R3, R4, R5 Y A TIENEN LA SIGNIFICACION DADA Y D ES UN RESTO DE LA FORMULA DONDE R13 Y R14 TIENEN EL SIGNIFICADO DADO, PUEDEN SER FABRICADAS EN UN PROCESO DE ALQUILIZACION DE LA PIRIDONA CON NITROGENO. LOS COMPUESTOS BIFENILPIRIDONA SUSTITUIDOS SON ADECUADOS COMO SUSTANCIA ACTIVA EN MEDICAMENTOS, ESPECIALMENTE EN REDUCTORES DE LA TENSION ARTERIAL Y MEDICAMENTOS ANTIATEROSCLEROTICOS.
ES92118597T 1991-11-12 1992-10-30 Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii. Expired - Lifetime ES2086046T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (1)

Publication Number Publication Date
ES2086046T3 true ES2086046T3 (es) 1996-06-16

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92118597T Expired - Lifetime ES2086046T3 (es) 1991-11-12 1992-10-30 Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii.

Country Status (23)

Country Link
US (2) US5356911A (es)
EP (1) EP0542059B1 (es)
JP (1) JPH05255258A (es)
KR (1) KR930010030A (es)
CN (1) CN1038935C (es)
AT (1) ATE135700T1 (es)
AU (1) AU659235B2 (es)
CA (1) CA2082306A1 (es)
CZ (1) CZ281937B6 (es)
DE (2) DE4221583A1 (es)
DK (1) DK0542059T3 (es)
ES (1) ES2086046T3 (es)
FI (1) FI925100L (es)
GR (1) GR3019398T3 (es)
HU (1) HUT67018A (es)
IL (1) IL103688A (es)
MX (1) MX9206305A (es)
MY (1) MY109880A (es)
NO (1) NO303541B1 (es)
NZ (1) NZ245073A (es)
RU (1) RU2100350C1 (es)
SK (1) SK279433B6 (es)
TW (1) TW218874B (es)

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DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
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TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
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US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
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MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
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WO2006055708A2 (en) * 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids for the treatment of diabetes
CA2591413A1 (en) * 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
EP1919905B1 (en) * 2005-08-29 2011-02-23 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-recptor tyrosine kinases
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
JP2009506123A (ja) 2005-08-29 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
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AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP5852666B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
WO2013093484A1 (en) * 2011-12-21 2013-06-27 Ono Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor xia inhibitors
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KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
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CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
CN1034934C (zh) * 1990-06-19 1997-05-21 明治制果株式会社 血管紧张素ii拮抗性吡啶衍生物的制备方法
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CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
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Also Published As

Publication number Publication date
DK0542059T3 (da) 1996-07-22
MX9206305A (es) 1993-05-01
NZ245073A (en) 1996-02-27
CA2082306A1 (en) 1993-05-12
US5599823A (en) 1997-02-04
TW218874B (es) 1994-01-11
CN1038935C (zh) 1998-07-01
HU9203552D0 (en) 1993-01-28
NO924172L (no) 1993-05-14
AU2823292A (en) 1993-05-13
IL103688A (en) 1997-02-18
CZ338092A3 (en) 1993-09-15
DE4221583A1 (de) 1993-05-13
HUT67018A (en) 1995-01-30
CN1072180A (zh) 1993-05-19
EP0542059A1 (de) 1993-05-19
CZ281937B6 (cs) 1997-04-16
FI925100A7 (fi) 1993-05-13
FI925100A0 (fi) 1992-11-10
AU659235B2 (en) 1995-05-11
MY109880A (en) 1997-09-30
RU2100350C1 (ru) 1997-12-27
SK338092A3 (en) 1998-11-04
SK279433B6 (sk) 1998-11-04
US5356911A (en) 1994-10-18
DE59205752D1 (de) 1996-04-25
GR3019398T3 (en) 1996-06-30
JPH05255258A (ja) 1993-10-05
NO303541B1 (no) 1998-07-27
EP0542059B1 (de) 1996-03-20
NO924172D0 (no) 1992-10-29
ATE135700T1 (de) 1996-04-15
IL103688A0 (en) 1993-04-04
FI925100L (fi) 1993-05-13
KR930010030A (ko) 1993-06-21

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