ES2086046T3 - Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii. - Google Patents

Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii.

Info

Publication number
ES2086046T3
ES2086046T3 ES92118597T ES92118597T ES2086046T3 ES 2086046 T3 ES2086046 T3 ES 2086046T3 ES 92118597 T ES92118597 T ES 92118597T ES 92118597 T ES92118597 T ES 92118597T ES 2086046 T3 ES2086046 T3 ES 2086046T3
Authority
ES
Spain
Prior art keywords
substituted
biphenyl
piridones
angiotensin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92118597T
Other languages
English (en)
Inventor
Matthias Dr Muller-Gliemann
Martin Dr Beuck
Stanislav Prof Dr Kazda
Johannes-Peter Dr Stasch
Andreas Dr Knorr
Stefan Dr Wohlfeil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2086046T3 publication Critical patent/ES2086046T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

BIFENIL PIRIDONA SUSTITUIDA DE LA FORMULA GENERAL EN DONDE R1, R2, R3, R4, R5 Y A TIENEN LA SIGNIFICACION DADA Y D ES UN RESTO DE LA FORMULA DONDE R13 Y R14 TIENEN EL SIGNIFICADO DADO, PUEDEN SER FABRICADAS EN UN PROCESO DE ALQUILIZACION DE LA PIRIDONA CON NITROGENO. LOS COMPUESTOS BIFENILPIRIDONA SUSTITUIDOS SON ADECUADOS COMO SUSTANCIA ACTIVA EN MEDICAMENTOS, ESPECIALMENTE EN REDUCTORES DE LA TENSION ARTERIAL Y MEDICAMENTOS ANTIATEROSCLEROTICOS.
ES92118597T 1991-11-12 1992-10-30 Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii. Expired - Lifetime ES2086046T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone

Publications (1)

Publication Number Publication Date
ES2086046T3 true ES2086046T3 (es) 1996-06-16

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92118597T Expired - Lifetime ES2086046T3 (es) 1991-11-12 1992-10-30 Bifenilpiridonas sustituidas como antagonistas de la angiotensina ii.

Country Status (23)

Country Link
US (2) US5356911A (es)
EP (1) EP0542059B1 (es)
JP (1) JPH05255258A (es)
KR (1) KR930010030A (es)
CN (1) CN1038935C (es)
AT (1) ATE135700T1 (es)
AU (1) AU659235B2 (es)
CA (1) CA2082306A1 (es)
CZ (1) CZ281937B6 (es)
DE (2) DE4221583A1 (es)
DK (1) DK0542059T3 (es)
ES (1) ES2086046T3 (es)
FI (1) FI925100A7 (es)
GR (1) GR3019398T3 (es)
HU (1) HUT67018A (es)
IL (1) IL103688A (es)
MX (1) MX9206305A (es)
MY (1) MY109880A (es)
NO (1) NO303541B1 (es)
NZ (1) NZ245073A (es)
RU (1) RU2100350C1 (es)
SK (1) SK279433B6 (es)
TW (1) TW218874B (es)

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DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
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GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
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US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
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MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2005307718A1 (en) * 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids for the treatment of diabetes
AU2005316540A1 (en) * 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones useful as inhibitors of Tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
ATE528302T1 (de) 2005-08-29 2011-10-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind
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CA2696948C (en) 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
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MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2782999T3 (es) * 2009-11-06 2020-09-16 Aerpio Therapeutics Inc Composiciones y métodos para tratar la colitis
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
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EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
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Also Published As

Publication number Publication date
US5599823A (en) 1997-02-04
DE4221583A1 (de) 1993-05-13
CA2082306A1 (en) 1993-05-12
FI925100A0 (fi) 1992-11-10
MY109880A (en) 1997-09-30
CN1072180A (zh) 1993-05-19
NO303541B1 (no) 1998-07-27
KR930010030A (ko) 1993-06-21
FI925100L (fi) 1993-05-13
FI925100A7 (fi) 1993-05-13
CZ338092A3 (en) 1993-09-15
AU2823292A (en) 1993-05-13
EP0542059A1 (de) 1993-05-19
JPH05255258A (ja) 1993-10-05
DK0542059T3 (da) 1996-07-22
NO924172L (no) 1993-05-14
IL103688A (en) 1997-02-18
DE59205752D1 (de) 1996-04-25
CZ281937B6 (cs) 1997-04-16
SK338092A3 (en) 1998-11-04
EP0542059B1 (de) 1996-03-20
GR3019398T3 (en) 1996-06-30
MX9206305A (es) 1993-05-01
HU9203552D0 (en) 1993-01-28
HUT67018A (en) 1995-01-30
AU659235B2 (en) 1995-05-11
ATE135700T1 (de) 1996-04-15
SK279433B6 (sk) 1998-11-04
IL103688A0 (en) 1993-04-04
US5356911A (en) 1994-10-18
TW218874B (es) 1994-01-11
NZ245073A (en) 1996-02-27
NO924172D0 (no) 1992-10-29
CN1038935C (zh) 1998-07-01
RU2100350C1 (ru) 1997-12-27

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