ES2087180T3 - Nuevos 2,6-di-alquil-4-sililfenoles utiles como agentes antiateroescleroticos y como antioxidantes. - Google Patents

Nuevos 2,6-di-alquil-4-sililfenoles utiles como agentes antiateroescleroticos y como antioxidantes.

Info

Publication number
ES2087180T3
ES2087180T3 ES91111252T ES91111252T ES2087180T3 ES 2087180 T3 ES2087180 T3 ES 2087180T3 ES 91111252 T ES91111252 T ES 91111252T ES 91111252 T ES91111252 T ES 91111252T ES 2087180 T3 ES2087180 T3 ES 2087180T3
Authority
ES
Spain
Prior art keywords
useful
sililfenoles
alquil
antioxidants
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111252T
Other languages
English (en)
Inventor
Roger A Parker
Simon Jen Tan Mao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2087180T3 publication Critical patent/ES2087180T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

ESTA INVENCION SE REFIERE A CIERTOS 2,6-DI-SILIL-FENOLES QUE SON UTILES COMO INHIBIDORES DE LA PEROXIDACION DE LOS LIPIDOS LDL Y COMO AGENTES ANTIATEROSCLEROTICOS.
ES91111252T 1990-07-05 1991-07-05 Nuevos 2,6-di-alquil-4-sililfenoles utiles como agentes antiateroescleroticos y como antioxidantes. Expired - Lifetime ES2087180T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Publications (1)

Publication Number Publication Date
ES2087180T3 true ES2087180T3 (es) 1996-07-16

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91111252T Expired - Lifetime ES2087180T3 (es) 1990-07-05 1991-07-05 Nuevos 2,6-di-alquil-4-sililfenoles utiles como agentes antiateroescleroticos y como antioxidantes.

Country Status (20)

Country Link
US (2) US5155250A (es)
EP (1) EP0464852B1 (es)
JP (1) JP2963556B2 (es)
KR (1) KR0186005B1 (es)
CN (1) CN1029615C (es)
AT (1) ATE135705T1 (es)
AU (1) AU639576B2 (es)
CA (1) CA2046051C (es)
DE (1) DE69118028T2 (es)
DK (1) DK0464852T3 (es)
ES (1) ES2087180T3 (es)
FI (1) FI101703B1 (es)
GR (1) GR3019393T3 (es)
HU (1) HU211074B (es)
IE (1) IE912340A1 (es)
IL (1) IL98712A (es)
NO (1) NO180490C (es)
NZ (1) NZ238808A (es)
PT (1) PT98220B (es)
ZA (1) ZA915074B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5304668A (en) * 1990-07-05 1994-04-19 Merrell Dow Pharmaceuticals Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
ES2233937T3 (es) * 1993-12-10 2005-06-16 Merrell Pharmaceuticals Inc. Metodo para disminuir los niveles de colesterol serico con 2,6-dialquil-4-silil-fenoles.
EP0734398B1 (en) * 1993-12-15 2002-02-27 Smithkline Beecham Corporation Compounds and methods
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
JP2000509070A (ja) * 1996-04-30 2000-07-18 ヘキスト・マリオン・ルセル・インコーポレイテツド ２，６―ジアルキル―４―シリル―フェノールを使用して血管細胞接着分子―１を阻害する方法および慢性炎症性疾患を治療する方法
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
EP0900241B1 (en) * 1996-05-20 2004-01-28 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
ATE356113T1 (de) * 1997-05-14 2007-03-15 Atherogenics Inc Probucolbernsteinsäureester zur hemmung der expression von vcam-1
ES2190592T3 (es) * 1997-06-24 2003-08-01 Aventis Pharma Inc Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes.
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AU7588498A (en) * 1997-06-25 1999-01-04 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol
AU8282798A (en) * 1997-07-01 1999-01-25 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
AU1911200A (en) * 1998-11-09 2000-05-29 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
CA2428753C (en) 2000-11-17 2013-05-21 Universita Degli Studi Di Cagliari Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CN100415227C (zh) * 2001-10-25 2008-09-03 阿特罗吉尼克斯公司 化合物在制备用于治疗移植排斥的药物中的应用
WO2003039352A2 (en) * 2001-11-09 2003-05-15 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
WO2004062622A2 (en) * 2003-01-13 2004-07-29 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
US20060058268A1 (en) * 2004-07-01 2006-03-16 Sundell Cynthia L Compounds and methods for treating diabetic vascular diseases
EP2139320A4 (en) * 2007-03-26 2010-09-08 Salutria Pharmaceuticals Llc METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (es) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
DE2933206A1 (de) * 1978-08-18 1980-02-28 Ciba Geigy Ag Phenolhaltige silane und deren verwendung als schmiermittelzusaetze
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
EP0464852B1 (en) 1996-03-20
US5155250A (en) 1992-10-13
DK0464852T3 (da) 1996-04-15
IE912340A1 (en) 1992-01-15
NO180490C (no) 1997-04-30
NO912630L (no) 1992-01-06
JPH04230393A (ja) 1992-08-19
JP2963556B2 (ja) 1999-10-18
GR3019393T3 (en) 1996-06-30
HU912272D0 (en) 1991-12-30
AU8011691A (en) 1992-01-09
ATE135705T1 (de) 1996-04-15
PT98220B (pt) 1998-12-31
KR0186005B1 (ko) 1999-05-15
NZ238808A (en) 1994-02-25
KR920002617A (ko) 1992-02-28
NO912630D0 (no) 1991-07-04
NO180490B (no) 1997-01-20
DE69118028T2 (de) 1996-11-28
US5532400A (en) 1996-07-02
CN1029615C (zh) 1995-08-30
FI913252A0 (fi) 1991-07-04
IL98712A0 (en) 1992-07-15
CA2046051C (en) 2001-06-05
HU211074B (en) 1995-10-30
AU639576B2 (en) 1993-07-29
FI101703B (fi) 1998-08-14
HUT58749A (en) 1992-03-30
EP0464852A1 (en) 1992-01-08
CA2046051A1 (en) 1992-01-06
DE69118028D1 (de) 1996-04-25
FI913252L (fi) 1992-01-06
PT98220A (pt) 1992-05-29
IL98712A (en) 1995-11-27
CN1057843A (zh) 1992-01-15
ZA915074B (en) 1992-04-29
FI101703B1 (fi) 1998-08-14

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