ES2087515T3 - Electrodo de ph. - Google Patents
Electrodo de ph.Info
- Publication number
- ES2087515T3 ES2087515T3 ES92902080T ES92902080T ES2087515T3 ES 2087515 T3 ES2087515 T3 ES 2087515T3 ES 92902080 T ES92902080 T ES 92902080T ES 92902080 T ES92902080 T ES 92902080T ES 2087515 T3 ES2087515 T3 ES 2087515T3
- Authority
- ES
- Spain
- Prior art keywords
- cannula
- surrounded
- reference material
- membrane
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical class [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000012925 reference material Substances 0.000 abstract 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- 229910021607 Silver chloride Inorganic materials 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 239000003230 hygroscopic agent Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1482—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means specially adapted for foetal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/4035—Combination of a single ion-sensing electrode and a single reference electrode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pediatric Medicine (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Cold Cathode And The Manufacture (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Materials For Medical Uses (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
UN ELECTRODO DE PH ADECUADO PARA USO IN VITRO ESTA PROVISTO DE UNA CANULA (10), Y COMPRENDE UN HILO DE PLATA CLORURADO (14) RODEADO POR UN MATERIAL DE REFERENCIA INTERNO NO ESTABILIZADOR (16) QUE COMPRENDE CLORURO DE POTASIO, CLORURO DE PLATA, ACIDO CITRICO Y SORBITOL COMO AGENTE HIGROSCOPICO. EL MATERIAL (16) ESTA RODEADO POR UN MANGUITO DE PVC (12). LA PUNTA DE LA CANULA (10) TIENE UNA MEMBRANA BASADA EN POLIMERO SENSIBLE AL PH (20) EN SU EXTREMO. EL MATERIAL DE REFERENCIA TIENE UN PH CUANDO TIENE UNA HIDRATACION DE ALREDEDOR DE 2 LO CUAL ESTA POR DEBAJO DEL RANGO DE RESPUESTA DE PH DE LA MEMBRANA (20).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100525A GB9100525D0 (en) | 1991-01-10 | 1991-01-10 | Ph electrodes |
| GB919121810A GB9121810D0 (en) | 1991-10-15 | 1991-10-15 | Ph electrode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2087515T3 true ES2087515T3 (es) | 1996-07-16 |
Family
ID=26298243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92902080T Expired - Lifetime ES2087515T3 (es) | 1991-01-10 | 1992-01-09 | Electrodo de ph. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5354449A (es) |
| EP (1) | EP0520053B1 (es) |
| JP (1) | JPH05505754A (es) |
| AT (1) | ATE135463T1 (es) |
| AU (1) | AU643369B2 (es) |
| BR (1) | BR9204099A (es) |
| CA (1) | CA2076546A1 (es) |
| DE (1) | DE69208948T2 (es) |
| DK (1) | DK0520053T3 (es) |
| ES (1) | ES2087515T3 (es) |
| WO (1) | WO1992012418A1 (es) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| DE10004583C2 (de) * | 2000-02-02 | 2002-04-25 | Testo Gmbh & Co | Messvorrichtung mit Einstechelektrode |
| FR2808882B1 (fr) * | 2000-05-15 | 2002-08-09 | Schlumberger Services Petrol | Electrode adaptee a des mesures en milieux agressifs |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| CN100422727C (zh) * | 2002-05-21 | 2008-10-01 | 株式会社百利达 | 电化学传感器 |
| JP2004045373A (ja) * | 2002-05-21 | 2004-02-12 | Tanita Corp | 電気化学式センサ |
| US7761130B2 (en) | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| WO2005012873A2 (en) | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Electrode systems for electrochemical sensors |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US6931327B2 (en) | 2003-08-01 | 2005-08-16 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20100168543A1 (en) | 2003-08-01 | 2010-07-01 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
| US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US8615282B2 (en) | 2004-07-13 | 2013-12-24 | Dexcom, Inc. | Analyte sensor |
| WO2005051170A2 (en) | 2003-11-19 | 2005-06-09 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
| DE602004029092D1 (de) | 2003-12-05 | 2010-10-21 | Dexcom Inc | Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7905833B2 (en) | 2004-07-13 | 2011-03-15 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
| US20090076360A1 (en) | 2007-09-13 | 2009-03-19 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US8219173B2 (en) | 2008-09-30 | 2012-07-10 | Abbott Diabetes Care Inc. | Optimizing analyte sensor calibration |
| US9675290B2 (en) | 2012-10-30 | 2017-06-13 | Abbott Diabetes Care Inc. | Sensitivity calibration of in vivo sensors used to measure analyte concentration |
| US20140066736A1 (en) * | 2006-03-31 | 2014-03-06 | Abbott Diabetes Care Inc. | Analyte Sensor Calibration Management |
| US8346335B2 (en) | 2008-03-28 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte sensor calibration management |
| WO2007143225A2 (en) | 2006-06-07 | 2007-12-13 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
| US7831287B2 (en) | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8562558B2 (en) | 2007-06-08 | 2013-10-22 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8262878B2 (en) * | 2007-07-25 | 2012-09-11 | Sierra Medical Technology, Inc. | Controlled activation pH sensor |
| EP4159114B1 (en) | 2007-10-09 | 2024-04-10 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
| EP2252196A4 (en) | 2008-02-21 | 2013-05-15 | Dexcom Inc | SYSTEMS AND METHOD FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA |
| US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
| US8560039B2 (en) | 2008-09-19 | 2013-10-15 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| US8597274B2 (en) | 2009-05-22 | 2013-12-03 | Abbott Diabetes Care Inc. | Usability features for integrated insulin delivery system |
| ES2912584T3 (es) | 2009-08-31 | 2022-05-26 | Abbott Diabetes Care Inc | Un sistema y procedimiento de monitorización de glucosa |
| US20120265036A1 (en) | 2011-04-15 | 2012-10-18 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| US20150114836A1 (en) * | 2011-09-06 | 2015-04-30 | William Clark | Measurement Device with Reader and Disposable Probe |
| DE102012101004A1 (de) * | 2012-02-08 | 2013-08-08 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Elektrode zur Verwendung in elektrochemischen Messsystemen |
| GB201210439D0 (en) * | 2012-06-13 | 2012-07-25 | Softcell Medicals | Apparatus |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| CN111246797B (zh) | 2017-10-24 | 2025-09-09 | 德克斯康公司 | 预连接分析物传感器 |
| KR102873075B1 (ko) * | 2018-10-02 | 2025-10-17 | 바이탈트레이스 피티와이 엘티디 | 태아 중의 분석물 농도를 모니터링하기 위한 장치, 시스템 및 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3676319A (en) * | 1969-03-28 | 1972-07-11 | Radiometer As | Electrode, half cell and electrode component for the measurement of electromotive force |
| FR2420331A1 (fr) * | 1978-03-23 | 1979-10-19 | Claude Bernard | Tete de mesure combinee, destinee a etre mise en place sur ou dans des parties corporelles, permettant l'obtention simultanee de signaux de mesure relatifs a une activite electrique d'une part et a une activite ionique d'autre part |
| JPS56157849A (en) * | 1980-05-09 | 1981-12-05 | Toshiba Corp | Ion selective electrode |
| JPS57149953A (en) * | 1981-03-13 | 1982-09-16 | Saburo Yanagisawa | Coated type reference electrode |
| DE3475005D1 (en) * | 1983-08-03 | 1988-12-08 | Medtronic Inc | Ion sensing electrode and methods for producing such electrodes and ion-selective membranes therefor |
| AU569918B2 (en) * | 1983-10-13 | 1988-02-25 | Ici Australia Operations Proprietary Limited | Redox potential or ph electrode |
| US4734184A (en) * | 1985-08-29 | 1988-03-29 | Diamond Sensor Systems, Inc. | Self-activating hydratable solid-state electrode apparatus |
| US4708776A (en) * | 1986-07-28 | 1987-11-24 | Eastman Kodak Company | Sodium ion selective electrode and method of use |
| US4981570A (en) * | 1986-12-10 | 1991-01-01 | Terumo Kabushiki Kaisha | Ion carrier membrane, and ion sensor having same |
| US4871439A (en) * | 1987-02-05 | 1989-10-03 | Steven Enzer | Disposable self-calibratable electrode package |
| AU2713588A (en) * | 1987-11-02 | 1989-06-01 | Biologix Inc. | Electrode system for use in a portable blood chemistry measuring apparatus |
| DK61488D0 (da) * | 1988-02-05 | 1988-02-05 | Novo Industri As | Fremgangsmaade |
| AU6511390A (en) * | 1989-09-06 | 1991-04-08 | Institut Gornogo Dela Sibirskogo Otdelenia Akademii Nauk Sssr | Method for trenchless replacement of a pipeline |
| US5110441A (en) * | 1989-12-14 | 1992-05-05 | Monsanto Company | Solid state ph sensor |
-
1992
- 1992-01-02 US US07/927,676 patent/US5354449A/en not_active Expired - Lifetime
- 1992-01-09 DK DK92902080.8T patent/DK0520053T3/da active
- 1992-01-09 CA CA002076546A patent/CA2076546A1/en not_active Abandoned
- 1992-01-09 EP EP92902080A patent/EP0520053B1/en not_active Expired - Lifetime
- 1992-01-09 DE DE69208948T patent/DE69208948T2/de not_active Expired - Fee Related
- 1992-01-09 AU AU11610/92A patent/AU643369B2/en not_active Ceased
- 1992-01-09 ES ES92902080T patent/ES2087515T3/es not_active Expired - Lifetime
- 1992-01-09 AT AT92902080T patent/ATE135463T1/de not_active IP Right Cessation
- 1992-01-09 BR BR929204099A patent/BR9204099A/pt not_active Application Discontinuation
- 1992-01-09 WO PCT/GB1992/000049 patent/WO1992012418A1/en not_active Ceased
- 1992-01-09 JP JP92502572A patent/JPH05505754A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE135463T1 (de) | 1996-03-15 |
| JPH05505754A (ja) | 1993-08-26 |
| WO1992012418A1 (en) | 1992-07-23 |
| EP0520053B1 (en) | 1996-03-13 |
| CA2076546A1 (en) | 1992-07-11 |
| DK0520053T3 (da) | 1996-04-01 |
| DE69208948D1 (de) | 1996-04-18 |
| AU643369B2 (en) | 1993-11-11 |
| AU1161092A (en) | 1992-08-17 |
| EP0520053A1 (en) | 1992-12-30 |
| DE69208948T2 (de) | 1996-09-12 |
| BR9204099A (pt) | 1993-05-04 |
| US5354449A (en) | 1994-10-11 |
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