ES2088925T3 - Promotores de la actividad del factor estimulador de colonias. - Google Patents

Promotores de la actividad del factor estimulador de colonias.

Info

Publication number
ES2088925T3
ES2088925T3 ES90113097T ES90113097T ES2088925T3 ES 2088925 T3 ES2088925 T3 ES 2088925T3 ES 90113097 T ES90113097 T ES 90113097T ES 90113097 T ES90113097 T ES 90113097T ES 2088925 T3 ES2088925 T3 ES 2088925T3
Authority
ES
Spain
Prior art keywords
promoters
stimulating factor
activity
mip
colonies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113097T
Other languages
English (en)
Inventor
Stephen D Wolpe
Anthony Cerami
Barbara Sherry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Application granted granted Critical
Publication of ES2088925T3 publication Critical patent/ES2088925T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A LA IDENTIFICACION DE PROMOTORES DE LA PRODUCCION DE LAS CELULAS MIELOPOIETICAS DE LA ASNGRE. EN PARTICULAR, SE HA DECUBIERTO UN AGENTE QUE INCREMENTA EL FACTOR DE ACTIVACION DE LA ESTIMULACION DE LAS COLONIAS MIELOPOIETICAS. EL AGENTE COMPRENDE CITOQUINAS QUE ADEMAS SON CAPACES DE UNIRSE A LA HEPARINA, E INDUCIR LA INFLAMACION LOCAL CARACTERIZADA POR LA INFILTRACION CELULAR POLIMORFONUCLEAR CUANDO SE ADMINISTRA SUBCUTANEAMENTE. LOS AGENTES PARTICULARES COMPRENDEN LAS CITOQUINAS INFLAMATORIAS MIP-1 Y MIP-2. SE PROPONEN EMPLEOS DIAGNOSTICOS Y TERAPEUTICOS, ASI COMO COMPOSICIONES FARMACEUTICAS.
ES90113097T 1989-07-10 1990-07-09 Promotores de la actividad del factor estimulador de colonias. Expired - Lifetime ES2088925T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37793789A 1989-07-10 1989-07-10

Publications (1)

Publication Number Publication Date
ES2088925T3 true ES2088925T3 (es) 1996-10-01

Family

ID=23491090

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113097T Expired - Lifetime ES2088925T3 (es) 1989-07-10 1990-07-09 Promotores de la actividad del factor estimulador de colonias.

Country Status (12)

Country Link
EP (1) EP0409040B1 (es)
JP (1) JPH04501860A (es)
AT (1) ATE129158T1 (es)
AU (1) AU638473B2 (es)
CA (1) CA2035861A1 (es)
DE (1) DE69023060T2 (es)
DK (1) DK0409040T3 (es)
ES (1) ES2088925T3 (es)
GR (1) GR3018675T3 (es)
IE (1) IE72139B1 (es)
PT (1) PT94641A (es)
WO (1) WO1991000919A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145676A (en) * 1981-09-08 1992-09-08 The Rockefeller University Method and agents for promoting wound healing
US5154921A (en) * 1990-07-13 1992-10-13 Dana-Farber Cancer Institute, Inc. Promotion of maturation of hematopoietic progenitor cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1208546A (en) * 1981-09-08 1986-07-29 Anthony Cerami Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
ATE149176T1 (de) * 1987-10-02 1997-03-15 Univ Rockefeller Von makrophagen abstammender entzündungsvermittler(mip-1-alpha et mip-1-beta)
ATE154364T1 (de) * 1988-09-02 1997-06-15 Univ Rockefeller Makrophagenabgeleiteter entzündungsmediator(mip- 2)

Also Published As

Publication number Publication date
CA2035861A1 (en) 1991-01-11
PT94641A (pt) 1991-04-18
DE69023060T2 (de) 1996-04-18
ATE129158T1 (de) 1995-11-15
JPH04501860A (ja) 1992-04-02
EP0409040B1 (en) 1995-10-18
DE69023060D1 (de) 1995-11-23
AU6040290A (en) 1991-02-06
WO1991000919A1 (en) 1991-01-24
DK0409040T3 (da) 1995-12-27
AU638473B2 (en) 1993-07-01
EP0409040A1 (en) 1991-01-23
IE72139B1 (en) 1997-03-26
GR3018675T3 (en) 1996-04-30

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