ES2088948T3 - Nuevo procedimiento para la preparacion de nojirimicina y compuestos relacionados. - Google Patents

Nuevo procedimiento para la preparacion de nojirimicina y compuestos relacionados.

Info

Publication number
ES2088948T3
ES2088948T3 ES90124580T ES90124580T ES2088948T3 ES 2088948 T3 ES2088948 T3 ES 2088948T3 ES 90124580 T ES90124580 T ES 90124580T ES 90124580 T ES90124580 T ES 90124580T ES 2088948 T3 ES2088948 T3 ES 2088948T3
Authority
ES
Spain
Prior art keywords
preparation
nojirimycin
related compounds
new procedure
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90124580T
Other languages
English (en)
Inventor
Peter B Anzeveno
Laura J Creemer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2088948T3 publication Critical patent/ES2088948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO Y EFICAZ CAMINO PARA LA PREPARACION DE (+) JIRIMICINA QUE TRAE CONSIGO LA AMINACION ESTEROSELECTIVA REDUCTORA DE 1,2-O-ISOPROPILENO -5OXO-(ALFA)-D-GLUCURONOLACTONA. LA AMINACION REDUCTORA UTILIZA OXIMAS PARTICULARES DEL COMPUESTO 5-OXO.
ES90124580T 1989-12-20 1990-12-18 Nuevo procedimiento para la preparacion de nojirimicina y compuestos relacionados. Expired - Lifetime ES2088948T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45364789A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
ES2088948T3 true ES2088948T3 (es) 1996-10-01

Family

ID=23801471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90124580T Expired - Lifetime ES2088948T3 (es) 1989-12-20 1990-12-18 Nuevo procedimiento para la preparacion de nojirimicina y compuestos relacionados.

Country Status (14)

Country Link
US (1) US5227479A (es)
EP (1) EP0433978B1 (es)
JP (1) JP2938193B2 (es)
KR (1) KR0147819B1 (es)
AT (1) ATE137758T1 (es)
AU (1) AU632191B2 (es)
DE (1) DE69026912T2 (es)
DK (1) DK0433978T3 (es)
ES (1) ES2088948T3 (es)
GR (1) GR3020492T3 (es)
HU (1) HU207866B (es)
IE (1) IE72513B1 (es)
IL (1) IL96694A (es)
ZA (1) ZA9010083B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066807A (en) * 1990-03-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Process for the preparation of castanospermine
US6462197B2 (en) 2000-03-31 2002-10-08 Board Of Trustees Of Michigan State University Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
DE3628486A1 (de) * 1986-08-22 1988-02-25 Bayer Ag Piperidinderivate
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds

Also Published As

Publication number Publication date
DE69026912T2 (de) 1996-10-02
AU6808490A (en) 1991-06-27
US5227479A (en) 1993-07-13
ATE137758T1 (de) 1996-05-15
IE72513B1 (en) 1997-04-23
IE904598A1 (en) 1991-07-03
HU908300D0 (en) 1991-06-28
DE69026912D1 (de) 1996-06-13
IL96694A (en) 1994-12-29
DK0433978T3 (da) 1996-05-28
KR0147819B1 (ko) 1998-08-01
HU207866B (en) 1993-06-28
IL96694A0 (en) 1991-09-16
JPH0418072A (ja) 1992-01-22
ZA9010083B (en) 1991-10-30
AU632191B2 (en) 1992-12-17
EP0433978A2 (en) 1991-06-26
EP0433978A3 (en) 1992-09-09
JP2938193B2 (ja) 1999-08-23
HUT57224A (en) 1991-11-28
KR910011882A (ko) 1991-08-07
EP0433978B1 (en) 1996-05-08
GR3020492T3 (en) 1996-10-31

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