ES2089027T3 - Forma de dosificacion transmucosica. - Google Patents

Forma de dosificacion transmucosica.

Info

Publication number
ES2089027T3
ES2089027T3 ES90913359T ES90913359T ES2089027T3 ES 2089027 T3 ES2089027 T3 ES 2089027T3 ES 90913359 T ES90913359 T ES 90913359T ES 90913359 T ES90913359 T ES 90913359T ES 2089027 T3 ES2089027 T3 ES 2089027T3
Authority
ES
Spain
Prior art keywords
drug
mouth
absorption
methods
mucosal tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90913359T
Other languages
English (en)
Inventor
Theodore H Stanley
Brian Hague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Application granted granted Critical
Publication of ES2089027T3 publication Critical patent/ES2089027T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/54—Composite products, e.g. layered, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/56—Products with edible or inedible supports, e.g. lollipops
    • A23G3/563—Products with edible or inedible supports, e.g. lollipops products with an inedible support, e.g. a stick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/003—Sticks, e.g. lollipops with drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Management Or Editing Of Information On Record Carriers (AREA)
  • Auxiliary Devices For Music (AREA)

Abstract

COMPOSICIONES Y METODOS DE FABRICACION PARA PRODUCIR UNA COMPOSICION MEDICINAL CAPAZ DE SER ABSORBIDA A TRAVES DE LOS TEJIDOS MUCOSOS DE LA BOCA, FARINGE Y ESOFAGO. ESTA INVENCION DESCRIBE LAS COMPOSICIONES Y METODOS QUE SON UTILES EN LA ADMINISTRACION DE MEDICAMENTOS LIPOFILICOS Y NOLIPOFILICOS DE UNA MANERA DOSIS A EFECTO TAL QUE SE ADMINISTRE SUFICIENTE MEDICAMENTO PARA PRODUCIR CON PRECISION UN EFECTO DESEADO. LA INVENCION DESCRIBE TAMBIEN TECNICAS DE FABRICACION QUE PERMITE INCORPORAR AGENTES TERAPEUTICOS (30) EN MATRICES DE CONTENIDO DE MEDICAMENTOS INDISOLUBLES (34) QUE SON CAPACES DE LIBERAR EL MEDICAMENTO DENTRO DE LA BOCA DE UN PACIENTE. HAY UN APARATO O SUJETADOR (36) PREFERENTEMENTE UNIDO A LA MATRIZ QUE CONTIENE EL MEDICAMENTO (34). EMPLEANDO ESTA INVENCION EL MEDICAMENTO (30) SE PUEDE INTRODUCIR EN LA CORRIENTE SANGUINEA DEL PACIENTE CASI TAN DEPRISA COMO A TRAVES DE UNA INYECCION, Y MUCHO MAS DEPRISA QUE UTILIZANDO LA RUTA DE ADMINISTRACION ORAL, MIENTRAS QUE SE EVITAN LOS ASPECTOS NEGATIVOS DE AMBOS METODOS. LA MATRIZ QUE CONTIENE EL MEDICAMENTO INDISOLUBLE (34) PUEDE INCLUIR REALZADORES DE PERMEABILIDAD PARA INCREMENTAR LA ABSORCION DEL MEDICAMENTO POR LOS TEJIDOS MUCOSOS DE LA BOCA. LA COMPOSICION DE LA MATRIZ (34) PUEDE INCLUIR TAMBIEN AGENTES TAMPONES PH PARA MODIFICAR EL PH DE LA SALIVA, INCREMENTANDO ASI LA ABSORCION DEL MEDICAMENTO (30) A TRAVES DE LOS TEJIDOS MUCOSOS.
ES90913359T 1989-09-05 1990-08-03 Forma de dosificacion transmucosica. Expired - Lifetime ES2089027T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/403,752 US5288498A (en) 1985-05-01 1989-09-05 Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments

Publications (1)

Publication Number Publication Date
ES2089027T3 true ES2089027T3 (es) 1996-10-01

Family

ID=23596874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90913359T Expired - Lifetime ES2089027T3 (es) 1989-09-05 1990-08-03 Forma de dosificacion transmucosica.

Country Status (11)

Country Link
US (1) US5288498A (es)
EP (1) EP0490944B1 (es)
JP (1) JP2749198B2 (es)
AT (1) ATE138562T1 (es)
AU (1) AU642664B2 (es)
CA (1) CA2066403C (es)
DE (1) DE69027216T2 (es)
DK (1) DK0490944T3 (es)
ES (1) ES2089027T3 (es)
NO (1) NO920858D0 (es)
WO (1) WO1991003236A1 (es)

Families Citing this family (153)

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AU6337190A (en) 1991-04-08
JPH05500058A (ja) 1993-01-14
EP0490944B1 (en) 1996-05-29
US5288498A (en) 1994-02-22
DE69027216D1 (de) 1996-07-04
NO920858L (no) 1992-03-04
CA2066403A1 (en) 1991-03-06
CA2066403C (en) 1998-04-14
NO920858D0 (no) 1992-03-04
EP0490944A4 (en) 1992-08-05
EP0490944A1 (en) 1992-06-24
AU642664B2 (en) 1993-10-28
DK0490944T3 (da) 1996-10-21
DE69027216T2 (de) 1996-10-17
WO1991003236A1 (en) 1991-03-21
JP2749198B2 (ja) 1998-05-13
ATE138562T1 (de) 1996-06-15

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