ES2089367T3 - Molecula de dna recombinante para la expresion del fragmento fv de un anticuerpo. - Google Patents
Molecula de dna recombinante para la expresion del fragmento fv de un anticuerpo.Info
- Publication number
- ES2089367T3 ES2089367T3 ES92202294T ES92202294T ES2089367T3 ES 2089367 T3 ES2089367 T3 ES 2089367T3 ES 92202294 T ES92202294 T ES 92202294T ES 92202294 T ES92202294 T ES 92202294T ES 2089367 T3 ES2089367 T3 ES 2089367T3
- Authority
- ES
- Spain
- Prior art keywords
- fragment
- antibody
- interferon
- recombinant dna
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA INVENCION PROPORCIONA UNA MOLECULA DE ADN RECOMBINANTE PARA LA EXPRESION DE UN FRAGMENTO FV FUNCIONAL DE UN ANTICUERPO DESEADO, DIRIGIDO HACIA EL INTERFERON, QUE COMPRENDE UNA SECUENCIA DE UN PROMOTOR HOMOLOGO, UNA SECUENCIA DE UN TERMINADOR HOMOLOGO Y UNA SECUENCIA DE ADN HETEROLOGO DICISTRONICO, CUYOS CISTRONES CODIFICAN LA PARTE VARIABLE DE UNA CADENA PESADA (VH) DEL ANTICUERPO ANTI-INTERFERON DESEADO Y LA PARTE VARIABLE DE UNA CADENA LIGERA (VK) DEL ANTICUERPO ANTI-INTERFERON DESEADO, RESPECTIVAMENTE. EL FRAGMENTO FV RECOMBINANTE, PRODUCIDO POR LA EXPRESION DE LA MOLECULA DE ADN RECOMBINANTE DE LA INVENCION ES UN HUESPED ADECUADO, SE PUEDE EMPLEAR PARA NEUTRALIZAR LA ACTIVIDAD BIOLOGICA DEL INTERFERON-GAMMA, QUE PUEDE SER PERJUDICIAL PARA EL HUESPED. EL USO DE UN FRAGMENTO FV REDUCE LAS RESPUESTAS ANTI-INMUNOGLOBULINA PROVOCADAS EN UN HUESPED AL QUE SE ADMINISTRAN INMUMOGLOBULINAS EXTRAÑAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9101290A NL9101290A (nl) | 1991-07-23 | 1991-07-23 | Recombinant dna-molecuul voor de expressie van een fv-fragment van een antilichaam. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2089367T3 true ES2089367T3 (es) | 1996-10-01 |
Family
ID=19859551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92202294T Expired - Lifetime ES2089367T3 (es) | 1991-07-23 | 1992-07-23 | Molecula de dna recombinante para la expresion del fragmento fv de un anticuerpo. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0528469B1 (es) |
| AT (1) | ATE140028T1 (es) |
| DE (1) | DE69211922T2 (es) |
| ES (1) | ES2089367T3 (es) |
| NL (1) | NL9101290A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| US20020025316A1 (en) | 1995-08-18 | 2002-02-28 | Ferguson Mark Williams James | Pharmaceutical composition containing inhibitors of interferon-gamma |
| GB2304342A (en) * | 1995-08-18 | 1997-03-19 | Univ Manchester | Pharmaceutical comprising either an inhibitor or a stimulator of interferon gamma |
| WO2004034988A2 (en) | 2002-10-16 | 2004-04-29 | Amgen Inc. | Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI903489A7 (fi) * | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
-
1991
- 1991-07-23 NL NL9101290A patent/NL9101290A/nl not_active Application Discontinuation
-
1992
- 1992-07-23 AT AT92202294T patent/ATE140028T1/de not_active IP Right Cessation
- 1992-07-23 ES ES92202294T patent/ES2089367T3/es not_active Expired - Lifetime
- 1992-07-23 DE DE69211922T patent/DE69211922T2/de not_active Expired - Fee Related
- 1992-07-23 EP EP92202294A patent/EP0528469B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL9101290A (nl) | 1993-02-16 |
| DE69211922T2 (de) | 1997-02-27 |
| EP0528469B1 (en) | 1996-07-03 |
| EP0528469A1 (en) | 1993-02-24 |
| DE69211922D1 (de) | 1996-08-08 |
| ATE140028T1 (de) | 1996-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 528469 Country of ref document: ES |
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